Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H30N2O5 |
| Molecular Weight | 402.484 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@H]3CCC[C@H]3C[C@H]2C(O)=O
InChI
InChIKey=DBAQBRAQKYAQEO-GBBGEASQSA-N
InChI=1S/C22H30N2O5/c1-14(20(25)24-18-10-6-9-16(18)13-19(24)21(26)27)23-17(22(28)29-2)12-11-15-7-4-3-5-8-15/h3-5,7-8,14,16-19,23H,6,9-13H2,1-2H3,(H,26,27)/t14-,16-,17-,18-,19-/m0/s1
| Molecular Formula | C22H30N2O5 |
| Molecular Weight | 402.484 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Ramipril methyl ester is the proline-containing impurity of ramipril, labelled as ramipril Impurity A. It is one of the four qualified impurities. Impurity A is the manufacture process impurity. Ramipril is an angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure (hypertension) and congestive heart failure.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Quality by design approach: application of artificial intelligence techniques of tablets manufactured by direct compression. | 2012-12 |
|
| Development of a capillary electrophoresis method for the assay of ramipril and its impurities: an issue of cis-trans isomerization. | 2011-05-06 |
|
| Development and validation of a liquid chromatographic method for the determination of the related substances of ramipril in Altace capsules. | 2000-09 |
Patents
| Substance Class |
Chemical
Created
by
admin
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Edited
Mon Mar 31 21:59:14 GMT 2025
by
admin
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Mon Mar 31 21:59:14 GMT 2025
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QKQ7F3PK42
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| Record Status |
Validated (UNII)
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108313-11-7
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| Related Record | Type | Details | ||
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PARENT -> IMPURITY |
