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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H30N2O5
Molecular Weight 402.484
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RAMIPRIL METHYL ESTER

SMILES

[H][C@@]12CCC[C@]1([H])N([C@@H](C2)C(O)=O)C(=O)[C@H](C)N[C@@H](CCC3=CC=CC=C3)C(=O)OC

InChI

InChIKey=DBAQBRAQKYAQEO-GBBGEASQSA-N
InChI=1S/C22H30N2O5/c1-14(20(25)24-18-10-6-9-16(18)13-19(24)21(26)27)23-17(22(28)29-2)12-11-15-7-4-3-5-8-15/h3-5,7-8,14,16-19,23H,6,9-13H2,1-2H3,(H,26,27)/t14-,16-,17-,18-,19-/m0/s1

HIDE SMILES / InChI

Molecular Formula C22H30N2O5
Molecular Weight 402.484
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 5 / 5
E/Z Centers 0
Optical Activity UNSPECIFIED

Ramipril methyl ester is the proline-containing impurity of ramipril, labelled as ramipril Impurity A. It is one of the four qualified impurities. Impurity A is the manufacture process impurity. Ramipril is an angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure (hypertension) and congestive heart failure.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Development and validation of a liquid chromatographic method for the determination of the related substances of ramipril in Altace capsules.
2000 Sep
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 08:18:00 GMT 2023
Edited
by admin
on Sat Dec 16 08:18:00 GMT 2023
Record UNII
QKQ7F3PK42
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RAMIPRIL METHYL ESTER
Common Name English
RAMIPRIL RELATED COMPOUND A [USP-RS]
Common Name English
RAMIPRIL RELATED COMPOUND A [USP IMPURITY]
Common Name English
RAMIPRIL IMPURITY A [EP IMPURITY]
Common Name English
CYCLOPENTA(B)PYRROLE-2-CARBOXYLIC ACID, OCTAHYDRO-1-((2S)-2-(((1S)-1-(METHOXYCARBONYL)-3-PHENYLPROPYL)AMINO)-1-OXOPROPYL)-, (2S,3AS,6AS)-
Systematic Name English
(2S,3AS,6AS)-1-((S)2-(((S)1-(METHOXYCARBONYL)-3-PHENYLPROPYL)AMINO)-1-OXOPROPYL)-OCTAHYDROCYCLOPENTA(B)PYRROLE-2-CARBOXYLIC ACID
Systematic Name English
RAMIPRIL RELATED COMPOUND A
USP  
Common Name English
Code System Code Type Description
FDA UNII
QKQ7F3PK42
Created by admin on Sat Dec 16 08:18:00 GMT 2023 , Edited by admin on Sat Dec 16 08:18:00 GMT 2023
PRIMARY
RS_ITEM_NUM
1598314
Created by admin on Sat Dec 16 08:18:00 GMT 2023 , Edited by admin on Sat Dec 16 08:18:00 GMT 2023
PRIMARY
PUBCHEM
11611080
Created by admin on Sat Dec 16 08:18:00 GMT 2023 , Edited by admin on Sat Dec 16 08:18:00 GMT 2023
PRIMARY
CAS
108313-11-7
Created by admin on Sat Dec 16 08:18:00 GMT 2023 , Edited by admin on Sat Dec 16 08:18:00 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP