Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | 2Na.B12HS |
| Molecular Weight | 199.208 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 2 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].S[10B]1234[10B]567[10B]89%10[10B]%11%12%13[10B]58%14[10B]%11%15%16[10B]%12%17%18[10B]9%13%19[10B]16%10[10B]2%17%19[10B]3%15%18[10B]47%14%16
InChI
InChIKey=XBQFDQBIJSZPQI-YCWCXYHTSA-N
InChI=1S/B12HS.2Na/c13-12-7-2-1-3(2,7)5(1)6(1)4(1,2)8(2,7,12)10(4,6,12)11(5,6,12)9(3,5,7)12;;/h13H;;/q;2*+1/i1-1,2-1,3-1,4-1,5-1,6-1,7-1,8-1,9-1,10-1,11-1,12-1;;
Borocaptate sodium B10 (also known as sodium borocaptate), a boron compound for use in boron neutron capture therapy. After parenteral administration, sodium borocaptate accumulates preferentially in tumor cells. When exposed to neutron irradiation, borocaptate absorbs neutrons and self-destructs releasing short-range alpha radiation and 'recoil' lithium in tumor cells, resulting in alpha radiation-induced tumor cell death. This highly selective, localized radio targeting of tumor cells, known as boron neutron capture therapy, spares adjacent normal tissues. Borocaptate sodium B10 was involved in phase I clinical trial in treating patients with glioblastoma multiforme removed during surgery to study the side effects. In addition, this compound participated in phase I clinical trials in tissues of patients with primary, metastatic, or recurrent thyroid cancer, head and neck cancer, or liver metastases from colorectal cancer to study the side effects. Besides, borocaptate sodium B10 was involved in phase-I clinical trials for Glioma in the European Union, however, this study was discontinued.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Evaluation of a novel sodium borocaptate-containing unnatural amino acid as a boron delivery agent for neutron capture therapy of the F98 rat glioma. | 2017-01-23 |
|
| Biodistribution of sodium borocaptate (BSH) for boron neutron capture therapy (BNCT) in an oral cancer model. | 2013-08 |
|
| Effect of electroporation on cell killing by boron neutron capture therapy using borocaptate sodium (10B-BSH). | 1998-12 |
|
| Borocaptate sodium: a potential boron delivery compound for boron neutron capture therapy evaluated in dogs with spontaneous intracranial tumors. | 1992-12-15 |
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT00062348
Patients receive sodium borocaptate (BSH) IV over 1 hour. Twelve hours later, patients undergo surgical resection
Route of Administration:
Intravenous
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Preferred Name | English | ||
|
Official Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
AA-104
Created by
admin on Mon Mar 31 21:07:11 GMT 2025 , Edited by admin on Mon Mar 31 21:07:11 GMT 2025
|
PRIMARY | |||
|
SUB10553MIG
Created by
admin on Mon Mar 31 21:07:11 GMT 2025 , Edited by admin on Mon Mar 31 21:07:11 GMT 2025
|
PRIMARY | |||
|
6482
Created by
admin on Mon Mar 31 21:07:11 GMT 2025 , Edited by admin on Mon Mar 31 21:07:11 GMT 2025
|
PRIMARY | |||
|
C171878
Created by
admin on Mon Mar 31 21:07:11 GMT 2025 , Edited by admin on Mon Mar 31 21:07:11 GMT 2025
|
PRIMARY | |||
|
12448-24-7
Created by
admin on Mon Mar 31 21:07:11 GMT 2025 , Edited by admin on Mon Mar 31 21:07:11 GMT 2025
|
PRIMARY | |||
|
103831-41-0
Created by
admin on Mon Mar 31 21:07:11 GMT 2025 , Edited by admin on Mon Mar 31 21:07:11 GMT 2025
|
SUPERSEDED | |||
|
Q99U4EH59F
Created by
admin on Mon Mar 31 21:07:11 GMT 2025 , Edited by admin on Mon Mar 31 21:07:11 GMT 2025
|
PRIMARY | |||
|
100000083526
Created by
admin on Mon Mar 31 21:07:11 GMT 2025 , Edited by admin on Mon Mar 31 21:07:11 GMT 2025
|
PRIMARY |
SUBSTANCE RECORD