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Details

Stereochemistry ACHIRAL
Molecular Formula 2Na.B12HS
Molecular Weight 199.208
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 2

SHOW SMILES / InChI
Structure of BOROCAPTATE SODIUM B-10

SMILES

[Na+].[Na+].S[10B]1234[10B]567[10B]89%10[10B]%11%12%13[10B]58%14[10B]%11%15%16[10B]%12%17%18[10B]9%13%19[10B]16%10[10B]2%17%19[10B]3%15%18[10B]47%14%16

InChI

InChIKey=XBQFDQBIJSZPQI-YCWCXYHTSA-N
InChI=1S/B12HS.2Na/c13-12-7-2-1-3(2,7)5(1)6(1)4(1,2)8(2,7,12)10(4,6,12)11(5,6,12)9(3,5,7)12;;/h13H;;/q;2*+1/i1-1,2-1,3-1,4-1,5-1,6-1,7-1,8-1,9-1,10-1,11-1,12-1;;

HIDE SMILES / InChI
Borocaptate sodium B10 (also known as sodium borocaptate), a boron compound for use in boron neutron capture therapy. After parenteral administration, sodium borocaptate accumulates preferentially in tumor cells. When exposed to neutron irradiation, borocaptate absorbs neutrons and self-destructs releasing short-range alpha radiation and 'recoil' lithium in tumor cells, resulting in alpha radiation-induced tumor cell death. This highly selective, localized radio targeting of tumor cells, known as boron neutron capture therapy, spares adjacent normal tissues. Borocaptate sodium B10 was involved in phase I clinical trial in treating patients with glioblastoma multiforme removed during surgery to study the side effects. In addition, this compound participated in phase I clinical trials in tissues of patients with primary, metastatic, or recurrent thyroid cancer, head and neck cancer, or liver metastases from colorectal cancer to study the side effects. Besides, borocaptate sodium B10 was involved in phase-I clinical trials for Glioma in the European Union, however, this study was discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
Evaluation of a novel sodium borocaptate-containing unnatural amino acid as a boron delivery agent for neutron capture therapy of the F98 rat glioma.
2017-01-23
Biodistribution of sodium borocaptate (BSH) for boron neutron capture therapy (BNCT) in an oral cancer model.
2013-08
Effect of electroporation on cell killing by boron neutron capture therapy using borocaptate sodium (10B-BSH).
1998-12
Borocaptate sodium: a potential boron delivery compound for boron neutron capture therapy evaluated in dogs with spontaneous intracranial tumors.
1992-12-15

Sample Use Guides

Patients receive sodium borocaptate (BSH) IV over 1 hour. Twelve hours later, patients undergo surgical resection
Route of Administration: Intravenous
Name Type Language
BOROCAPTATE SODIUM B-10
Common Name English
SODIUM BOROCAPTATE (10B)
INN  
INN  
Preferred Name English
BOROCAPTATE SODIUM B 10
USAN  
USAN  
Official Name English
sodium borocaptate (¹?B) [INN]
Common Name English
BOROLIFE
Brand Name English
BOROCAPTATE SODIUM B 10 [USAN]
Common Name English
NASH
Code English
BSH
Code English
Sodium borocaptate [WHO-DD]
Common Name English
DODECABORATE(2-)-10B12, 1,2,3,4,5,6,7,8,9,10,11-UNDECAHYDRO-12-MERCAPTO-, SODIUM (1:2)
Systematic Name English
SODIUM MERCAPTOUNDECAHYDRODODECABORATE-10B (NA210B12H11SH)
Common Name English
Code System Code Type Description
USAN
AA-104
Created by admin on Mon Mar 31 21:07:11 GMT 2025 , Edited by admin on Mon Mar 31 21:07:11 GMT 2025
PRIMARY
EVMPD
SUB10553MIG
Created by admin on Mon Mar 31 21:07:11 GMT 2025 , Edited by admin on Mon Mar 31 21:07:11 GMT 2025
PRIMARY
INN
6482
Created by admin on Mon Mar 31 21:07:11 GMT 2025 , Edited by admin on Mon Mar 31 21:07:11 GMT 2025
PRIMARY
NCI_THESAURUS
C171878
Created by admin on Mon Mar 31 21:07:11 GMT 2025 , Edited by admin on Mon Mar 31 21:07:11 GMT 2025
PRIMARY
CAS
12448-24-7
Created by admin on Mon Mar 31 21:07:11 GMT 2025 , Edited by admin on Mon Mar 31 21:07:11 GMT 2025
PRIMARY
CAS
103831-41-0
Created by admin on Mon Mar 31 21:07:11 GMT 2025 , Edited by admin on Mon Mar 31 21:07:11 GMT 2025
SUPERSEDED
FDA UNII
Q99U4EH59F
Created by admin on Mon Mar 31 21:07:11 GMT 2025 , Edited by admin on Mon Mar 31 21:07:11 GMT 2025
PRIMARY
SMS_ID
100000083526
Created by admin on Mon Mar 31 21:07:11 GMT 2025 , Edited by admin on Mon Mar 31 21:07:11 GMT 2025
PRIMARY