Details
Stereochemistry | ACHIRAL |
Molecular Formula | 2Na.B12HS |
Molecular Weight | 199.208 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 2 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].S[10B]1234[10B]567[10B]89%10[10B]%11%12%13[10B]58%14[10B]%11%15%16[10B]%12%17%18[10B]9%13%19[10B]16%10[10B]2%17%19[10B]3%15%18[10B]47%14%16
InChI
InChIKey=XBQFDQBIJSZPQI-YCWCXYHTSA-N
InChI=1S/B12HS.2Na/c13-12-7-2-1-3(2,7)5(1)6(1)4(1,2)8(2,7,12)10(4,6,12)11(5,6,12)9(3,5,7)12;;/h13H;;/q;2*+1/i1-1,2-1,3-1,4-1,5-1,6-1,7-1,8-1,9-1,10-1,11-1,12-1;;
Molecular Formula | B12HS |
Molecular Weight | 153.228 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | Na |
Molecular Weight | 22.9898 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Borocaptate sodium B10 (also known as sodium borocaptate), a boron compound for use in boron neutron capture therapy. After parenteral administration, sodium borocaptate accumulates preferentially in tumor cells. When exposed to neutron irradiation, borocaptate absorbs neutrons and self-destructs releasing short-range alpha radiation and 'recoil' lithium in tumor cells, resulting in alpha radiation-induced tumor cell death. This highly selective, localized radio targeting of tumor cells, known as boron neutron capture therapy, spares adjacent normal tissues. Borocaptate sodium B10 was involved in phase I clinical trial in treating patients with glioblastoma multiforme removed during surgery to study the side effects. In addition, this compound participated in phase I clinical trials in tissues of patients with primary, metastatic, or recurrent thyroid cancer, head and neck cancer, or liver metastases from colorectal cancer to study the side effects. Besides, borocaptate sodium B10 was involved in phase-I clinical trials for Glioma in the European Union, however, this study was discontinued.
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Borocaptate sodium: a potential boron delivery compound for boron neutron capture therapy evaluated in dogs with spontaneous intracranial tumors. | 1992 Dec 15 |
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Biodistribution of sodium borocaptate (BSH) for boron neutron capture therapy (BNCT) in an oral cancer model. | 2013 Aug |
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT00062348
Patients receive sodium borocaptate (BSH) IV over 1 hour. Twelve hours later, patients undergo surgical resection
Route of Administration:
Intravenous
Substance Class |
Chemical
Created
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admin
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Edited
Sat Dec 16 02:01:57 GMT 2023
by
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on
Sat Dec 16 02:01:57 GMT 2023
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Record UNII |
Q99U4EH59F
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Record Status |
Validated (UNII)
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