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Details

Stereochemistry ACHIRAL
Molecular Formula 2Na.B12HS
Molecular Weight 199.208
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 2

SHOW SMILES / InChI
Structure of BOROCAPTATE SODIUM B-10

SMILES

[Na+].[Na+].S[10B]1234[10B]567[10B]89%10[10B]%11%12%13[10B]58%14[10B]%11%15%16[10B]%12%17%18[10B]9%13%19[10B]16%10[10B]2%17%19[10B]3%15%18[10B]47%14%16

InChI

InChIKey=XBQFDQBIJSZPQI-YCWCXYHTSA-N
InChI=1S/B12HS.2Na/c13-12-7-2-1-3(2,7)5(1)6(1)4(1,2)8(2,7,12)10(4,6,12)11(5,6,12)9(3,5,7)12;;/h13H;;/q;2*+1/i1-1,2-1,3-1,4-1,5-1,6-1,7-1,8-1,9-1,10-1,11-1,12-1;;

HIDE SMILES / InChI

Molecular Formula B12HS
Molecular Weight 153.228
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Borocaptate sodium B10 (also known as sodium borocaptate), a boron compound for use in boron neutron capture therapy. After parenteral administration, sodium borocaptate accumulates preferentially in tumor cells. When exposed to neutron irradiation, borocaptate absorbs neutrons and self-destructs releasing short-range alpha radiation and 'recoil' lithium in tumor cells, resulting in alpha radiation-induced tumor cell death. This highly selective, localized radio targeting of tumor cells, known as boron neutron capture therapy, spares adjacent normal tissues. Borocaptate sodium B10 was involved in phase I clinical trial in treating patients with glioblastoma multiforme removed during surgery to study the side effects. In addition, this compound participated in phase I clinical trials in tissues of patients with primary, metastatic, or recurrent thyroid cancer, head and neck cancer, or liver metastases from colorectal cancer to study the side effects. Besides, borocaptate sodium B10 was involved in phase-I clinical trials for Glioma in the European Union, however, this study was discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
Borocaptate sodium: a potential boron delivery compound for boron neutron capture therapy evaluated in dogs with spontaneous intracranial tumors.
1992 Dec 15
Biodistribution of sodium borocaptate (BSH) for boron neutron capture therapy (BNCT) in an oral cancer model.
2013 Aug

Sample Use Guides

Patients receive sodium borocaptate (BSH) IV over 1 hour. Twelve hours later, patients undergo surgical resection
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Sat Dec 16 02:01:57 GMT 2023
Edited
by admin
on Sat Dec 16 02:01:57 GMT 2023
Record UNII
Q99U4EH59F
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BOROCAPTATE SODIUM B-10
Common Name English
BOROCAPTATE SODIUM B 10
USAN  
USAN  
Official Name English
sodium borocaptate (¹⁰B) [INN]
Common Name English
BOROLIFE
Brand Name English
BOROCAPTATE SODIUM B 10 [USAN]
Common Name English
SODIUM BOROCAPTATE (10B)
INN  
INN  
Official Name English
NASH
Code English
BSH
Code English
Sodium borocaptate [WHO-DD]
Common Name English
DODECABORATE(2-)-10B12, 1,2,3,4,5,6,7,8,9,10,11-UNDECAHYDRO-12-MERCAPTO-, SODIUM (1:2)
Systematic Name English
SODIUM MERCAPTOUNDECAHYDRODODECABORATE-10B (NA210B12H11SH)
Common Name English
Code System Code Type Description
USAN
AA-104
Created by admin on Sat Dec 16 02:01:57 GMT 2023 , Edited by admin on Sat Dec 16 02:01:57 GMT 2023
PRIMARY
EVMPD
SUB10553MIG
Created by admin on Sat Dec 16 02:01:57 GMT 2023 , Edited by admin on Sat Dec 16 02:01:57 GMT 2023
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INN
6482
Created by admin on Sat Dec 16 02:01:57 GMT 2023 , Edited by admin on Sat Dec 16 02:01:57 GMT 2023
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NCI_THESAURUS
C171878
Created by admin on Sat Dec 16 02:01:57 GMT 2023 , Edited by admin on Sat Dec 16 02:01:57 GMT 2023
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CAS
12448-24-7
Created by admin on Sat Dec 16 02:01:57 GMT 2023 , Edited by admin on Sat Dec 16 02:01:57 GMT 2023
PRIMARY
CAS
103831-41-0
Created by admin on Sat Dec 16 02:01:57 GMT 2023 , Edited by admin on Sat Dec 16 02:01:57 GMT 2023
SUPERSEDED
FDA UNII
Q99U4EH59F
Created by admin on Sat Dec 16 02:01:57 GMT 2023 , Edited by admin on Sat Dec 16 02:01:57 GMT 2023
PRIMARY
SMS_ID
100000083526
Created by admin on Sat Dec 16 02:01:57 GMT 2023 , Edited by admin on Sat Dec 16 02:01:57 GMT 2023
PRIMARY