Details
Stereochemistry | ACHIRAL |
Molecular Formula | C21H25N |
Molecular Weight | 291.4299 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)CCC=C1C2=C(C=CC=C2)C(C)(C)C3=C1C=CC=C3
InChI
InChIKey=GWWLWDURRGNSRS-UHFFFAOYSA-N
InChI=1S/C21H25N/c1-21(2)19-13-7-5-10-17(19)16(12-9-15-22(3)4)18-11-6-8-14-20(18)21/h5-8,10-14H,9,15H2,1-4H3
DescriptionCurator's Comment: Description was created based on several sources, including https://www.aci-bd.com/Brand/Adelax.pdf and https://www.ncbi.nlm.nih.gov/pubmed/18331614
Curator's Comment: Description was created based on several sources, including https://www.aci-bd.com/Brand/Adelax.pdf and https://www.ncbi.nlm.nih.gov/pubmed/18331614
Melitracen (HCl) is a tricyclic antidepressant with actions and effects similar to amitriptyline.Melitracen (HCl) is given orally in the treatment of depression. It should be withdrawn gradually to reduce the risk of withdrawl symptoms. Melitracen (HCl) is primarily indicated in conditions like Anxiety, Asthenia, Depression, gastro-intestinal disorders associated with anxiety and agitation. Melitracen is marketed in Europe and Japan by Lundbeck and Takeda, respectively, for the treatment of depression and anxiety. In addition to single drug preparations, it is also available as Deanxit, a combination product containing both melitracen and flupentixol. The way this drug works hasn’t been thoroughly researched, but some hypothesize that it may work similarly to the drugs Imipramine and Amitriptyline. In comparison to older TCAs, this drug is thought to work more quickly with more favorable side effects.
Originator
Sources: https://lundbeck.com/cn/en/products/deanxit
Curator's Comment: Melitracen was patented in 1963 by Kefalas A/S
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Deanxit Approved UseAnxiety − Depression − Asthenia.
Neurasthenia, Psychogenic depression. Depressive neuroses. Masked depression.
Psychosomatic affections accompanied by anxiety and apathy. Menopausal depressions.
Dysphoria and depression in alcoholics and drug-addicts. Launch Date1997 |
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Primary | Deanxit Approved UseAnxiety − Depression − Asthenia.
Neurasthenia, Psychogenic depression. Depressive neuroses. Masked depression.
Psychosomatic affections accompanied by anxiety and apathy. Menopausal depressions.
Dysphoria and depression in alcoholics and drug-addicts. Launch Date1997 |
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Primary | Deanxit Approved UseAnxiety − Depression − Asthenia.
Neurasthenia, Psychogenic depression. Depressive neuroses. Masked depression.
Psychosomatic affections accompanied by anxiety and apathy. Menopausal depressions.
Dysphoria and depression in alcoholics and drug-addicts. Launch Date1997 |
PubMed
Title | Date | PubMed |
---|---|---|
Solid-phase extraction and analysis of 20 antidepressant drugs in human plasma by LC/MS with SSI method. | 2006 Oct 16 |
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Validation of a sensitive LC/MS/MS method for simultaneous quantitation of flupentixol and melitracene in human plasma. | 2007 Dec 21 |
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Comparison of electron and chemical ionization modes by validation of a quantitative gas chromatographic-mass spectrometric assay of new generation antidepressants and their active metabolites in plasma. | 2007 Dec 28 |
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[Efficacy and safety of Deanxit combined with Wuling Capsule in treating post-stroke depression: a randomized controlled trial]. | 2008 Mar |
Sample Use Guides
In Vivo Use Guide
Sources: http://www.genericpedia.com/generic/Melitracen/
Oral
Depression
Adult: Initially, 25 mg bid-tid, gradually increased to 225 mg daily if necessary.
Elderly: Initially, 25 mg daily.
Route of Administration:
Oral
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N06CA02
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)