MELITRACEN

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H25N
Molecular Weight	291.4299
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)CCC=C1C2=CC=CC=C2C(C)(C)C3=CC=CC=C13

InChI

InChIKey=GWWLWDURRGNSRS-UHFFFAOYSA-N

InChI=1S/C21H25N/c1-21(2)19-13-7-5-10-17(19)16(12-9-15-22(3)4)18-11-6-8-14-20(18)21/h5-8,10-14H,9,15H2,1-4H3

HIDE SMILES / InChI

Description
Sources: http://buddymd.com/side-effects-deanxit-flupentixol-melitracen
Curator's Comment: Description was created based on several sources, including https://www.aci-bd.com/Brand/Adelax.pdf and https://www.ncbi.nlm.nih.gov/pubmed/18331614

Melitracen (HCl) is a tricyclic antidepressant with actions and effects similar to amitriptyline.Melitracen (HCl) is given orally in the treatment of depression. It should be withdrawn gradually to reduce the risk of withdrawl symptoms. Melitracen (HCl) is primarily indicated in conditions like Anxiety, Asthenia, Depression, gastro-intestinal disorders associated with anxiety and agitation. Melitracen is marketed in Europe and Japan by Lundbeck and Takeda, respectively, for the treatment of depression and anxiety. In addition to single drug preparations, it is also available as Deanxit, a combination product containing both melitracen and flupentixol. The way this drug works hasn’t been thoroughly researched, but some hypothesize that it may work similarly to the drugs Imipramine and Amitriptyline. In comparison to older TCAs, this drug is thought to work more quickly with more favorable side effects.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Anxiety 275 Sources: http://www.papaloizou.com/PublicDocsPDF/SPCs/Deanxit_SPC.pdf	Primary	Approved 8583	Deanxit Approved Use Anxiety − Depression − Asthenia. Neurasthenia, Psychogenic depression. Depressive neuroses. Masked depression. Psychosomatic affections accompanied by anxiety and apathy. Menopausal depressions. Dysphoria and depression in alcoholics and drug-addicts. Launch Date 1997
Depression 240 Sources: http://www.mims.com/thailand/drug/info/deanxit/?type=full#Indications	Primary	Approved 8583	Deanxit Approved Use Anxiety − Depression − Asthenia. Neurasthenia, Psychogenic depression. Depressive neuroses. Masked depression. Psychosomatic affections accompanied by anxiety and apathy. Menopausal depressions. Dysphoria and depression in alcoholics and drug-addicts. Launch Date 1997
Asthenia 4 Sources: http://www.papaloizou.com/PublicDocsPDF/SPCs/Deanxit_SPC.pdf	Primary	Approved 8583	Deanxit Approved Use Anxiety − Depression − Asthenia. Neurasthenia, Psychogenic depression. Depressive neuroses. Masked depression. Psychosomatic affections accompanied by anxiety and apathy. Menopausal depressions. Dysphoria and depression in alcoholics and drug-addicts. Launch Date 1997

C_max

Value	Dose	Co-administered	Analyte	Population
9.7926 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31571834/	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered: FLUPENTIXOL	FLUPENTIXOL	MELITRACEN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
10.6205 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31571834/	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered: FLUPENTIXOL	FLUPENTIXOL	MELITRACEN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: HIGH-FAT

AUC

Value	Dose	Co-administered	Analyte	Population
453.7055 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31571834/	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered: FLUPENTIXOL	FLUPENTIXOL	MELITRACEN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
477.9061 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31571834/	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered: FLUPENTIXOL	FLUPENTIXOL	MELITRACEN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: HIGH-FAT

T_1/2

Value	Dose	Co-administered	Analyte	Population
72.793 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31571834/	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered: FLUPENTIXOL	FLUPENTIXOL	MELITRACEN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
67.1625 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31571834/	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered: FLUPENTIXOL	FLUPENTIXOL	MELITRACEN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: HIGH-FAT

F_unbound

Value	Dose	Co-administered	Analyte	Population
11% EXPERIMENT https://www.tandfonline.com/doi/abs/10.1080/09674845.2020.1819632?journalCode=tbbs20			MELITRACEN plasma	Homo sapiens

Doses

Dose	Population	Adverse events
10 mg single, oral Recommended Dose: 10 mg Route: oral Route: single Dose: 10 mg Sources: https://pubmed.ncbi.nlm.nih.gov/31571834/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: M+F Food Status: FASTED Sources: https://pubmed.ncbi.nlm.nih.gov/31571834/	Sources: https://pubmed.ncbi.nlm.nih.gov/31571834/

PubMed

Title	Date	PubMed
[Comparative study on abdominal acupuncture and western medicine for treatment of menopause depressive disorder].	2010-11	21246847
[Study on catgut implantation therapy compared with Deanxit for treatment of depression].	2010-08	20942276
Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography-mass spectrometry.	2009-11	18839201
Clinical trial: a randomized controlled cross-over study of flupenthixol + melitracen in functional dyspepsia.	2008-06-01	18331614
[Efficacy and safety of Deanxit combined with Wuling Capsule in treating post-stroke depression: a randomized controlled trial].	2008-03	18334144
Purple urine bag syndrome in nursing homes: ten elderly case reports and a literature review.	2008	19281065
Comparison of electron and chemical ionization modes by validation of a quantitative gas chromatographic-mass spectrometric assay of new generation antidepressants and their active metabolites in plasma.	2007-12-28	18022628
Validation of a sensitive LC/MS/MS method for simultaneous quantitation of flupentixol and melitracene in human plasma.	2007-12-21	17881181
Solid-phase extraction and analysis of 20 antidepressant drugs in human plasma by LC/MS with SSI method.	2006-10-16	16859851
Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis.	2005-12-09	16314157

Patents

Sample Use Guides

In Vivo Use Guide

Oral Depression Adult: Initially, 25 mg bid-tid, gradually increased to 225 mg daily if necessary. Elderly: Initially, 25 mg daily.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

ADELAX

Preferred Name

English

MELITRACEN

Official Name

English

1-PROPANAMINE, 3-(10,10-DIMETHYL-9(10H)-ANTHRACENYLIDENE)-N,N-DIMETHYL-

Systematic Name

English

melitracen [INN]

Common Name

English

MELITRACEN [MI]

Common Name

English

Melitracen [WHO-DD]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QN06CA02