Details
Stereochemistry | MIXED |
Molecular Formula | C14H32N2O4 |
Molecular Weight | 292.4149 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 0 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(O)CN(CCN(CC(C)O)CC(C)O)CC(C)O
InChI
InChIKey=NSOXQYCFHDMMGV-UHFFFAOYSA-N
InChI=1S/C14H32N2O4/c1-11(17)7-15(8-12(2)18)5-6-16(9-13(3)19)10-14(4)20/h11-14,17-20H,5-10H2,1-4H3
Quadrol, N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine, also known as edetol, is a registered trademark of BASF Corporation. Quadrol has proven to be an excellent cross-linking agent and catalyst for use in polyurethane coatings and rigid foams. The four hydroxyl groups in quadrol give multiple cross-linking sites and the two tertiary nitrogen atoms provide catalysis for the reaction. In addition, was studied the biological activity of quadrol: this compound promoted in vivo collagen synthesis and was effective as a stimulator of wound healing in diabetic and non-diabetic animals. Quadrol exists as a mixture of four unique diastereomers, each of which may display differences in biological activity.
Approval Year
PubMed
Title | Date | PubMed |
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Metal complexes of tetrapodal ligands: synthesis, spectroscopic and thermal studies, and X-ray crystal structure studies of Na(I), Ca(II), Sr(II), and Ba(II) complexes of tetrapodal ligands N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine and N,N,N',N'-tetrakis(2-hydroxyethyl)ethylenediamine. | 2002 Apr 22 |
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Magnetic resonance flow velocity and temperature mapping of a shape memory polymer foam device. | 2009 Dec 31 |
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Sorption of Cu(II) complexes with ligands tartrate, glycine and quadrol by chitosan. | 2009 Nov 15 |
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Decontamination of solutions containing Cu(II) and ligands tartrate, glycine and quadrol using metallic iron. | 2010 Mar 15 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3246540
normal and diabetic mice: the rate of collagen deposition in implanted polytetrafluoroethylene (PTFE) tubing in non-diabetic and streptozotocin-induced (STZ) diabetic mice was measured during 14 days post-wounding. At the time of implantation, test groups received injections of either quadrol (edetol; N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine], glucan, or buffer in an area adjacent to the wound site. Quadrol promotes in vivo collagen synthesis and that quadrol may be effective as a stimulator of wound healing in diabetic and non-diabetic animals.
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4056411
Curator's Comment: Mouse peritoneal macrophages, when exposed to Quadrol [N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine/edetol] in vitro, show a dose dependent enhanced spreading over a four-hour period. The rate and extent of the enhancement of phagocytosis was comparable to that observed for lipopolysaccharide and tuftsin.
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CONCEPT | Industrial Aid |
ACTIVE MOIETY