DescriptionCurator's Comment: Description was created based on several sources, including https://examine.com/supplements/evodia-rutaecarpa/ and http://www.itmonline.org/articles/evodia/evodia.htm
Curator's Comment: Description was created based on several sources, including https://examine.com/supplements/evodia-rutaecarpa/ and http://www.itmonline.org/articles/evodia/evodia.htm
Tetradium ruticarpum (Evodia rutaecarpa) is a plant, which belongs to a genus of 9 species of trees. It is known as Euodia or Bee bee tree in the west because it was classified to the genus Euodia in the ancient literature. The volatile oil of Tetradium ruticarpum (Evodia rutaecarpa) fruits contains evodene, evodol, and limonin. Fruits contain evodiamine, rutaecarpine, evocarpine, Hydroxyevodiamine, wuchuyine, ocimene, evodione, evogin, rutaevin, aspartic acid, tryptophan, threonine, serine, cystine, and so on. The fruit of Tetradium ruticarpum which is also known as Wu zhu yu (Wu Zhu Yu) or Evodia Fruit, is used in Traditional Chinese Medicine at doses of 3-9 grams (of the berries) thrice a day for the purposes of warmth, intestinal comfort (specifically; to alleviate abdominal pain, acid regurgitation, nausea and diarrhea), dysmenorrheal, and fighting inflammation and infections. It is frequently used in a combination supplement called Wu Zhu Yu Tang, which consists of Evodia fruit with Jujube Fruit and Panax Ginseng (1:1:1 ratio) and Ginger root (twice the amount of any one other ingredient) which is a decoction used for hypertension or as Zuo jin wanwhich is used for gastrointestinal distress alongside Rhizoma Coptidis at a 1:6 ratio (Evodia:Coptidis). Another decoction exists called Fan zuo jin wan, which is Rhizome Coptidis and Evodia in the inverse ratio. Tetradium ruticarpum fruit has also being shown to possess antitumor activity.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14705186
Curator's Comment: Dehydroevodiamine, a constituent of quinazoline alkaloids isolated from Tetradium ruticarpum fruit, can cross the blood brain barrier of the rat and enter the brain via linear kinetics
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: Tumor cell growth Sources: https://www.ncbi.nlm.nih.gov/pubmed/26421050 |
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Target ID: CHEMBL5132 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10985078 |
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Target ID: CHEMBL5102 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15305207 |
5.95 µM [Ki] | ||
Target ID: CHEMBL1781 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22402246 |
60.74 µM [IC50] | ||
Target ID: CHEMBL2094255 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22402246 |
78.81 µM [IC50] | ||
Target ID: Leukaemia cell growth Sources: https://www.ncbi.nlm.nih.gov/pubmed/22402246 |
34.43 µM [IC50] | ||
Target ID: map04210 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15102520 |
0.57 µM [IC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Palliative | Wu Zhu Yu Approved UseSevere pain in the epigastrium and abdomen, headaches, epigastric pain, nausea, drooling, reduced taste sensation, pale tongue, wiry or weak pulse, hernial disorders. |
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| Palliative | Wu Zhu Yu Approved UseSevere pain in the epigastrium and abdomen, headaches, epigastric pain, nausea, drooling, reduced taste sensation, pale tongue, wiry or weak pulse, hernial disorders. |
|||
| Primary | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways. | 2016-04 |
|
| Therapeutic and cosmetic applications of Evodiamine and its derivatives--A patent review. | 2015-10 |
|
| Effect and mechanism of evodiamine against ethanol-induced gastric ulcer in mice by suppressing Rho/NF-кB pathway. | 2015-09 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: http://www.itmonline.org/articles/evodia/evodia.htm
The dosage of evodia in decoction is most often indicated to be 3–9 grams.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16681034
Evodiamine (primary component of TETRADIUM RUTICARPUM FRUIT extract) inhibited prostaglandin E2 synthesis from lipopolysaccharide-treated RAW 264.7 cells at 1-10 uM.
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SUBSTANCE RECORD