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Description
Curator's Comment: Description was created based on several sources, including https://examine.com/supplements/evodia-rutaecarpa/ and http://www.itmonline.org/articles/evodia/evodia.htm

Tetradium ruticarpum (Evodia rutaecarpa) is a plant, which belongs to a genus of 9 species of trees. It is known as Euodia or Bee bee tree in the west because it was classified to the genus Euodia in the ancient literature. The volatile oil of Tetradium ruticarpum (Evodia rutaecarpa) fruits contains evodene, evodol, and limonin. Fruits contain evodiamine, rutaecarpine, evocarpine, Hydroxyevodiamine, wuchuyine, ocimene, evodione, evogin, rutaevin, aspartic acid, tryptophan, threonine, serine, cystine, and so on. The fruit of Tetradium ruticarpum which is also known as Wu zhu yu (Wu Zhu Yu) or Evodia Fruit, is used in Traditional Chinese Medicine at doses of 3-9 grams (of the berries) thrice a day for the purposes of warmth, intestinal comfort (specifically; to alleviate abdominal pain, acid regurgitation, nausea and diarrhea), dysmenorrheal, and fighting inflammation and infections. It is frequently used in a combination supplement called Wu Zhu Yu Tang, which consists of Evodia fruit with Jujube Fruit and Panax Ginseng (1:1:1 ratio) and Ginger root (twice the amount of any one other ingredient) which is a decoction used for hypertension or as Zuo jin wanwhich is used for gastrointestinal distress alongside Rhizoma Coptidis at a 1:6 ratio (Evodia:Coptidis). Another decoction exists called Fan zuo jin wan, which is Rhizome Coptidis and Evodia in the inverse ratio. Tetradium ruticarpum fruit has also being shown to possess antitumor activity.

CNS Activity

Curator's Comment: Dehydroevodiamine, a constituent of quinazoline alkaloids isolated from Tetradium ruticarpum fruit, can cross the blood brain barrier of the rat and enter the brain via linear kinetics

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
5.95 µM [Ki]
60.74 µM [IC50]
78.81 µM [IC50]
34.43 µM [IC50]
0.57 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Wu Zhu Yu

Approved Use

Severe pain in the epigastrium and abdomen, headaches, epigastric pain, nausea, drooling, reduced taste sensation, pale tongue, wiry or weak pulse, hernial disorders.
Palliative
Wu Zhu Yu

Approved Use

Severe pain in the epigastrium and abdomen, headaches, epigastric pain, nausea, drooling, reduced taste sensation, pale tongue, wiry or weak pulse, hernial disorders.
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways.
2016 Apr
Patents

Sample Use Guides

The dosage of evodia in decoction is most often indicated to be 3–9 grams.
Route of Administration: Oral
Evodiamine (primary component of TETRADIUM RUTICARPUM FRUIT extract) inhibited prostaglandin E2 synthesis from lipopolysaccharide-treated RAW 264.7 cells at 1-10 uM.
Substance Class Structurally Diverse
Created
by admin
on Fri Dec 15 19:56:06 UTC 2023
Edited
by admin
on Fri Dec 15 19:56:06 UTC 2023
Source Materials Class ORGANISM
Source Materials Type PLANT
Source Materials Parent
Part FRUIT
Record UNII
Q413WWJ3X9
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
TETRADIUM RUTICARPUM FRUIT
WHO-DD  
Common Name English
EUODIA RUTICARPA VAR. OFFICINALIS FRUIT
Systematic Name English
EUODIAE FRUCTUS [CHP]
Common Name English
EUODIA HIRSUTIFOLIA FRUIT
Common Name English
EUODIA RUTICARPA VAR. BODINIERI FRUIT
Systematic Name English
EUODIA FRUIT (EUODIA BODINIERI) [JP]
Common Name English
EUODIA FRUIT (EUODIA RUTICARPA) [JP]
Common Name English
EUODIA COMPACTA FRUIT
Common Name English
EUODIA RUGOSA FRUIT
Common Name English
EVODIAE FRUCTUS
Common Name English
EVODIA FRUIT
Common Name English
WU ZHU YU
Common Name English
WUZHUYU
Common Name English
EUODIA BODINIERI FRUIT
Common Name English
EVODIA RUTAECARPA FRUIT
WHO-DD  
Common Name English
BOYMIA RUTICARPA FRUIT
Common Name English
MEDICINAL EVODIA FRUIT
Common Name English
EUODIA RUTICARPA FRUIT
Common Name English
AMPACUS RUTICARPA FRUIT
Common Name English
EUODIA FRUIT (EUODIA OFFICINALIS) [JP]
Common Name English
EUODIA OFFICINALIS FRUIT
Common Name English
Evodia rutaecarpa fruit [WHO-DD]
Common Name English
Tetradium ruticarpum fruit [WHO-DD]
Common Name English
Code System Code Type Description
DAILYMED
Q413WWJ3X9
Created by admin on Fri Dec 15 19:56:06 UTC 2023 , Edited by admin on Fri Dec 15 19:56:06 UTC 2023
PRIMARY
EVMPD
SUB130966
Created by admin on Fri Dec 15 19:56:06 UTC 2023 , Edited by admin on Fri Dec 15 19:56:06 UTC 2023
PRIMARY
FDA UNII
Q413WWJ3X9
Created by admin on Fri Dec 15 19:56:06 UTC 2023 , Edited by admin on Fri Dec 15 19:56:06 UTC 2023
PRIMARY
RXCUI
1311684
Created by admin on Fri Dec 15 19:56:06 UTC 2023 , Edited by admin on Fri Dec 15 19:56:06 UTC 2023
PRIMARY
CHEBI
16226
Created by admin on Fri Dec 15 19:56:06 UTC 2023 , Edited by admin on Fri Dec 15 19:56:06 UTC 2023
PRIMARY
Related Record Type Details
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE