Details
Stereochemistry | RACEMIC |
Molecular Formula | C18H29NO3 |
Molecular Weight | 307.4278 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCN(CC)CC(C)(C)COC(=O)C(CO)C1=CC=CC=C1
InChI
InChIKey=ORXLOAFNULMXBG-UHFFFAOYSA-N
InChI=1S/C18H29NO3/c1-5-19(6-2)13-18(3,4)14-22-17(21)16(12-20)15-10-8-7-9-11-15/h7-11,16,20H,5-6,12-14H2,1-4H3
AMPROTROPINE (Syntropan) is the phosphate salt of
3 diethylamine, 2.2 dimethylpropanol
tropic acid ester. Syntropan is antispasmodic. Its main effect is parasympathetic, and its internal uses are
chiefly the same as those of atropine. Syntropan produces relaxation of the tone of the stomach and inhibition of peristaltic activity. The effect of syntropan on gastric secretion excited by a meat extract meal and histamine is weak as compared with atropine. Its
advantages as a mydriatic were also described: the rapid effect; the short duration; no general dangers nor discomforts; no local dangers, as damaging the corneal epithelium, or increasing the intraocular
pressure; no delay in returning to work for the patient.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18123466
Intravenous administration of Syntropan, in doses of 10–25 mg, decreased tonus and abolished waves for short periods of time in the stomach, duodenum, jejunum, ileum and colon, and also retarded transport of the balloon through the stomach and intestine. Undesirable side effects were encountered in all patients given the drug intravenously in doses of 10–25 mg.
Route of Administration:
Intravenous
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NCI_THESAURUS |
C29704
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admin on Fri Dec 15 16:15:28 GMT 2023 , Edited by admin on Fri Dec 15 16:15:28 GMT 2023
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C053014
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148-32-3
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8645
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DTXSID90933277
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C79938
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Q1S268DPRS
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3675
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)