Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C31H43NO10 |
| Molecular Weight | 589.6738 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 14 / 15 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12C[C@]3(O)[C@H](OC(=O)C4=CC=CC=C4)[C@]1([H])[C@@](O)([C@@H]5[C@H](OC)[C@@]6([H])[C@]27C5N(C)C[C@]6(COC)[C@H](O)C[C@@H]7OC)[C@@H](O)[C@@H]3OC
InChI
InChIKey=PULWZCUZNRVAHT-PUAFOYDXSA-N
InChI=1S/C31H43NO10/c1-32-13-28(14-38-2)17(33)11-18(39-3)30-16-12-29(36)25(42-27(35)15-9-7-6-8-10-15)19(16)31(37,24(34)26(29)41-5)20(23(30)32)21(40-4)22(28)30/h6-10,16-26,33-34,36-37H,11-14H2,1-5H3/t16-,17-,18+,19-,20?,21+,22-,23-,24+,25-,26+,28+,29-,30+,31-/m1/s1
DescriptionCurator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/7997462 | https://www.ncbi.nlm.nih.gov/pubmed/8282271 | https://www.ncbi.nlm.nih.gov/pubmed/9682963 | https://www.ncbi.nlm.nih.gov/pubmed/9682964 | |https://www.ncbi.nlm.nih.gov/pubmed/12543043
Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/7997462 | https://www.ncbi.nlm.nih.gov/pubmed/8282271 | https://www.ncbi.nlm.nih.gov/pubmed/9682963 | https://www.ncbi.nlm.nih.gov/pubmed/9682964 | |https://www.ncbi.nlm.nih.gov/pubmed/12543043
Benzoylmesaconine (BMA) is the main Aconitum alkaloid in Radix Aconiti Lateralis Preparata. Notably, the high levels of toxicity of Radix Aconiti are derived from diester aconitum alkaloids, including aconitine, mesaconitine and hypaconitine, which can be hydrolyzed to benzoylaconine, benzoylmesaconine and benzoylhypaconine, respectively. Benzoylmesaconine exhibits biological effects, including analgesic, antiviral and antifungal activities.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Analgesic effect of benzoylmesaconine]. | 1993 Dec |
|
| Antinociceptive mechanism of the aconitine alkaloids mesaconitine and benzoylmesaconine. | 1994 Oct |
|
| The regulation of burn-associated infections with herpes simplex virus type 1 or Candida albicans by a non-toxic aconitine-hydrolysate, benzoylmesaconine. Part 1: Antiviral and anti-fungal activities in thermally injured mice. | 1998 Jun |
|
| Therapeutic effects of IL-12 combined with benzoylmesaconine, a non-toxic aconitine-hydrolysate, against herpes simplex virus type 1 infection in mice following thermal injury. | 2003 Feb |
|
| An optimized high-performance liquid chromatography (HPLC) method for benzoylmesaconine determination in Radix Aconiti Lateralis Preparata (Fuzi, aconite roots) and its products. | 2008 May 30 |
|
| Pharmacokinetic comparisons of benzoylmesaconine in rats using ultra-performance liquid chromatography-tandem mass spectrometry after administration of pure benzoylmesaconine and Wutou decoction. | 2014 Oct 17 |
Patents
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
102004490
Created by
admin on Fri Dec 15 20:37:06 GMT 2023 , Edited by admin on Fri Dec 15 20:37:06 GMT 2023
|
PRIMARY | |||
|
PXJ8W3681R
Created by
admin on Fri Dec 15 20:37:06 GMT 2023 , Edited by admin on Fri Dec 15 20:37:06 GMT 2023
|
PRIMARY | |||
|
132630
Created by
admin on Fri Dec 15 20:37:06 GMT 2023 , Edited by admin on Fri Dec 15 20:37:06 GMT 2023
|
PRIMARY | |||
|
DTXSID10979273
Created by
admin on Fri Dec 15 20:37:06 GMT 2023 , Edited by admin on Fri Dec 15 20:37:06 GMT 2023
|
PRIMARY | |||
|
63238-67-5
Created by
admin on Fri Dec 15 20:37:06 GMT 2023 , Edited by admin on Fri Dec 15 20:37:06 GMT 2023
|
PRIMARY |
SUBSTANCE RECORD
