Details
Stereochemistry | UNKNOWN |
Molecular Formula | C17H14O4 |
Molecular Weight | 282.2907 |
Optical Activity | ( + ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1CCC2=C1C=C(O)C(=C2)C(=O)C3=CC=CC=C3
InChI
InChIKey=XMTKXTUIUKKGIL-UHFFFAOYSA-N
InChI=1S/C17H14O4/c18-15-9-13-11(6-7-12(13)17(20)21)8-14(15)16(19)10-4-2-1-3-5-10/h1-5,8-9,12,18H,6-7H2,(H,20,21)
Oxindanac, a non-steroidal anti-inflammatory drug, and is a weak cyclooxygenase inhibitor possessed antipyretic activity. This drug is used as a veterinary inflammatory drug. In addition, oxindanac was studied in phase III clinical trials for the treatment of rheumatic disorders. However, this study was discontinued.
Originator
Approval Year
PubMed
Title | Date | PubMed |
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The anti-oedematous efficacy of oxindanac equals that of paracetamol in acute postoperative inflammation; are weak cyclooxygenase inhibitors more effective than strong inhibitors? | 1989 |
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The use of intradermal carrageenan in calves to estimate the dose of oxindanac, a nonsteroidal anti-inflammatory drug. | 1993 Oct |
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High performance liquid chromatography and pharmacokinetics of the non-steroidal anti-inflammatory drug oxindanac in calves. | 1994 Jun |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2687006
Eight male volunteers receiving frusemide 40 mg b.d. were also given either oxindanac 300 mg b.d. or placebo in two consecutive periods separated by a treatment-free period, according to a randomized cross-over study design.
Route of Administration:
Oral
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99910-67-5
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68879
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PS75787KJI
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admin on Sat Dec 16 10:14:50 GMT 2023 , Edited by admin on Sat Dec 16 10:14:50 GMT 2023
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SUBSTANCE RECORD