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Details

Stereochemistry ACHIRAL
Molecular Formula C12H9N3O5
Molecular Weight 275.217
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of NIFUROXAZIDE

SMILES

OC1=CC=C(C=C1)C(=O)N\N=C\C2=CC=C(O2)[N+]([O-])=O

InChI

InChIKey=YCWSUKQGVSGXJO-NTUHNPAUSA-N
InChI=1S/C12H9N3O5/c16-9-3-1-8(2-4-9)12(17)14-13-7-10-5-6-11(20-10)15(18)19/h1-7,16H,(H,14,17)/b13-7+

HIDE SMILES / InChI

Description

Nifuroxazide is a nitrofuran antibiotic used for the treatment of acute infectious diarrhoea.Nifuroxazide is a potent inhibitor of Signal transducers and activators of transcription (STAT) signaling. It exerts antineoplastic potential both in vitro and in vivo.

Originator

Robert et Carriere
1

Approval Year

Unknown
139,594

Targets

Primary TargetPharmacologyConditionPotency
Signal transducer and activator of transcription 3
10
Inhibitor
8,297
 3.0 µM [EC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Cancer
592
 Primary
Preclinical
Unknown
Infectious diarrhea
8
 Curative
Approved
8,429
ERCEFURYL

PubMed

Patents

CN102657680B
1
US3290213
1
WO2008030141A1
1

Sample Use Guides

In Vivo Use Guide
200 mg nifuroxazide 4 times a day in 2 to 4 doses.
Route of Administration: Oral
In Vitro Use Guide
2.5-20 uM nifuroxazide induces breast cancer cell apoptosis in a concentration-dependent manner.
ACTIVE MOIETY
Structure of NIFUROXAZIDE
NIH
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