URSODEOXYCHOLYLGLYCINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H43NO5
Molecular Weight	449.6233
Optical Activity	UNSPECIFIED
Defined Stereocenters	10 / 10
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC(=O)NCC(O)=O

InChI

InChIKey=GHCZAUBVMUEKKP-XROMFQGDSA-N

InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/t15-,16+,17-,18-,19+,20+,21+,24+,25+,26-/m1/s1

HIDE SMILES / InChI

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Oxidative Stress 160 Target ID: WP1050 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19818102	Inhibitor 8297

PubMed

Title	Date	PubMed
pH-Solubility relations of chenodeoxycholic and ursodeoxycholic acids: physical-chemical basis for dissimilar solution and membrane phenomena.	1980 Jan	7354256
Positions of conjugation of bile acids with glucose and N-acetylglucosamine in vitro.	1994 Sep	7806974
Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter.	1998 Jan	9458785
Whole-cell response characteristics of ciliated and microvillous olfactory receptor neurons to amino acids, pheromone candidates and urine in rainbow trout.	2001 Nov	11705800
Ursodeoxycholic acid inhibits endothelin-1 production in human vascular endothelial cells.	2004 Nov 28	15556138
p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis.	2007 Nov 23	17881359
Bilirubin injury to neurons: contribution of oxidative stress and rescue by glycoursodeoxycholic acid.	2008 Mar	18164405
Contribution of inflammatory processes to nerve cell toxicity by bilirubin and efficacy of potential therapeutic agents.	2009	19754368