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Details

Stereochemistry ABSOLUTE
Molecular Formula C62H98N16O22.C2H4O2
Molecular Weight 1479.5875
Optical Activity UNSPECIFIED
Defined Stereocenters 12 / 12
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BPC-157 acetate

SMILES

CC(O)=O.CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]3CCCN3C(=O)[C@@H]4CCCN4C(=O)[C@H](CCC(O)=O)NC(=O)CN)C(=O)N[C@@H](C(C)C)C(O)=O

InChI

InChIKey=LIKSGLHWFDSWDW-OIBXLTBVSA-N
InChI=1S/C62H98N16O22.C2H4O2/c1-31(2)25-37(55(92)74-50(32(3)4)62(99)100)71-46(81)29-65-51(88)33(5)67-53(90)38(26-48(84)85)73-54(91)39(27-49(86)87)72-52(89)34(6)68-57(94)41-15-10-21-75(41)58(95)35(13-7-8-20-63)70-45(80)30-66-56(93)40-14-9-22-76(40)60(97)43-17-12-24-78(43)61(98)42-16-11-23-77(42)59(96)36(18-19-47(82)83)69-44(79)28-64;1-2(3)4/h31-43,50H,7-30,63-64H2,1-6H3,(H,65,88)(H,66,93)(H,67,90)(H,68,94)(H,69,79)(H,70,80)(H,71,81)(H,72,89)(H,73,91)(H,74,92)(H,82,83)(H,84,85)(H,86,87)(H,99,100);1H3,(H,3,4)/t33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,50-;/m0./s1

HIDE SMILES / InChI
Body protective compound – 15 also known as bepecin, BPC 157 or PL 14736, a small, chemically synthesized pentadecapeptide which has been shown to be safe in clinical trials for inflammatory bowel disease and may be able to cure intestinal anastomosis dehiscence. BPC 157 also was involved in phase I development in Ulcerative colitis, however, no reports of development identified. Recently published article has described that BPC 157 had huge potential as a therapy to conservatively treat or aid recovery in hypovascular and hypocellular soft tissues such as tendon and ligaments. Although is still a need to understand the precise healing mechanisms for this therapy to achieve clinical realization.

Approval Year

PubMed

PubMed

TitleDatePubMed
Therapy effect of antiulcer agents on new chronic cysteamine colon lesion in rat.
2001 Jan-Dec
Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL14736, Pliva, Croatia) heals ileoileal anastomosis in the rat.
2007

Sample Use Guides

Single dose of 1 oral tablet of PCO-02 containing 1 mg of Bepecin (12 subjects). Phase 1a: Healthy volunteers will take a single dose of 1, 3 or 6 tablets by mouth of PCO-02 containing 1 mg of Bepecin to study safety and pharmacokinetics. Phase 1b: All subjects will take 3 tablets of PCO-02 containing 1 mg of Bepecin every 8 hours during two weeks, to study safety and pharmacokinetics.
Route of Administration: Oral
Name Type Language
BPC-157 acetate
Common Name English
BPC-157 monoacetate
Common Name English
L-Valine, glycyl-L-α-glutamyl-L-prolyl-L-prolyl-L-prolylglycyl-L-lysyl-L-prolyl-L-alanyl-L-α-aspartyl-L-α-aspartyl-L-alanylglycyl-L-leucyl-, monoacetate
Systematic Name English
BPC 157 (acetate)
Common Name English
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val HOAc
Systematic Name English
Code System Code Type Description
PUBCHEM
155977614
Created by admin on Sat Dec 16 20:11:23 GMT 2023 , Edited by admin on Sat Dec 16 20:11:23 GMT 2023
PRIMARY
CAYMAN
30989
Created by admin on Sat Dec 16 20:11:23 GMT 2023 , Edited by admin on Sat Dec 16 20:11:23 GMT 2023
PRIMARY
CAS
216441-37-1
Created by admin on Sat Dec 16 20:11:23 GMT 2023 , Edited by admin on Sat Dec 16 20:11:23 GMT 2023
PRIMARY
FDA UNII
PAR2FC72XP
Created by admin on Sat Dec 16 20:11:23 GMT 2023 , Edited by admin on Sat Dec 16 20:11:23 GMT 2023
PRIMARY