Details
Stereochemistry | ACHIRAL |
Molecular Formula | C2H5NO2.Al.Cl.Zr.HO.H2O |
Molecular Weight | 263.748 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 5 |
SHOW SMILES / InChI
SMILES
O.[OH-].[Al+3].[Cl-].[Zr+4].NCC(O)=O
InChI
InChIKey=WYANSMZYIOPJFV-UHFFFAOYSA-L
InChI=1S/C2H5NO2.Al.ClH.2H2O.Zr/c3-1-2(4)5;;;;;/h1,3H2,(H,4,5);;1H;2*1H2;/q;+3;;;;+4/p-2
DescriptionSources: http://www.domeboro.com/about-domeboro/Curator's Comment: Description was created based on several sources, including
https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html
Sources: http://www.domeboro.com/about-domeboro/
Curator's Comment: Description was created based on several sources, including
https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html
Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate.
The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.
Originator
Sources: http://www.domeboro.com/about-domeboro/
Curator's Comment: Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2364031 |
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Target ID: GO:0042310 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | DOMEBORO Approved UseTemporarily relieves minor skin irritations due to:
– Poison ivy | – Poison oak
– Poison sumac | – Insect bites
– Athlete’s foot | – Rashes caused by soaps, detergents, cosmetics, or jewelry |
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Curative | DOMEBORO Approved UseThis medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection. |
PubMed
Title | Date | PubMed |
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The ineffectiveness of aluminum subacetate in rheumatoid arthritis. | 1948 Apr 8 |
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The antibacterial activity of acetic acid and Burow's solution as topical otological preparations. | 1998 Oct |
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Effect of aluminum phosphide on blood glucose level. | 1999 Feb |
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Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study. | 1999 May |
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Aluminum as a toxicant. | 2002 Aug |
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[Pharmaceutical and pharmacological evaluation of Burow's solution (aluminum acetate solution), hospital preparation, and development of its rapid preparation method]. | 2004 Nov |
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Aluminum and Alzheimer's disease, a personal perspective after 25 years. | 2006 |
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Some aspects of astroglial functions and aluminum implications for neurodegeneration. | 2006 Aug 30 |
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An effector domain mutant of Arf6 implicates phospholipase D in endosomal membrane recycling. | 2006 Jan |
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Aluminum and other metals in Alzheimer's disease: a review of potential therapy with chelating agents. | 2006 Nov |
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Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer's disease. | 2006 Nov |
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Ototoxic effect of Burow solution applied to the guinea pig middle ear. | 2007 Aug |
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Retrospective analysis of 4-week inhalation studies in rats with focus on fate and pulmonary toxicity of two nanosized aluminum oxyhydroxides (boehmite) and pigment-grade iron oxide (magnetite): the key metric of dose is particle mass and not particle surface area. | 2009 May 17 |
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Altered glucose homeostasis in response to aluminium phosphide induced cellular oxygen deficit in rat. | 2010 Jul |
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Molecular basis of carcinogenicity of tungsten alloy particles. | 2015 Mar 15 |
Sample Use Guides
DOMEBORO® SOOTHING SOAK
– dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water
– stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use
For use as a soak:
– soak affected area for 15 to 30 minutes as needed, or as directed by a doctor
– repeat 3 times a day or as directed by a doctor
– discard solution after each use.
For use as a compress or wet dressing:
– soak a clean, soft cloth in the solution.
– apply cloth loosely to affected area for 15 to 30 minutes
– repeat as needed or as directed by a doctor
– discard solution after each use
Route of Administration:
Topical
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CFR |
21 CFR 350.10
Created by
admin on Fri Dec 15 17:32:04 GMT 2023 , Edited by admin on Fri Dec 15 17:32:04 GMT 2023
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CHEMBL2109021
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1306096
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DB11200
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72941670
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P9D3YP29MY
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174514-58-0
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admin on Fri Dec 15 17:32:04 GMT 2023 , Edited by admin on Fri Dec 15 17:32:04 GMT 2023
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ACTIVE MOIETY