ALUMINUM ZIRCONIUM OCTACHLOROHYDREX GLY

US Approved OTC

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H5NO2.Al.Cl.Zr.HO.H2O
Molecular Weight	263.748
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	5

SHOW SMILES / InChI

Structure of ALUMINUM ZIRCONIUM OCTACHLOROHYDREX GLY

Structure Search

SMILES

O.[OH-].[Al+3].[Cl-].[Zr+4].NCC(O)=O

InChI

InChIKey=WYANSMZYIOPJFV-UHFFFAOYSA-L

InChI=1S/C2H5NO2.Al.ClH.2H2O.Zr/c3-1-2(4)5;;;;;/h1,3H2,(H,4,5);;1H;2*1H2;/q;+3;;;;+4/p-2

HIDE SMILES / InChI

Description
Sources: http://www.domeboro.com/about-domeboro/
Curator's Comment: Description was created based on several sources, including https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html

Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate. The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cell membrane 42 Target ID: CHEMBL2364031 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22718290 \| https://www.ncbi.nlm.nih.gov/pubmed/10211213	Interacts 323
vasoconstriction 32 Target ID: GO:0042310 Sources: https://www.drugs.com/monograph/aluminum-acetate.html	Activator 1430

Conditions

Condition	Modality	Targets	Highest Phase	Product
Itching 54 Sources: http://www.domeboro.com/about-domeboro/ https://www.drugs.com/monograph/aluminum-acetate.html	Primary		Approved 8429	DOMEBORO Approved Use Temporarily relieves minor skin irritations due to: – Poison ivy \| – Poison oak – Poison sumac \| – Insect bites – Athlete’s foot \| – Rashes caused by soaps, detergents, cosmetics, or jewelry
Otitis 40 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15516810 https://www.ncbi.nlm.nih.gov/pubmed/14724484 https://www.drugs.com/monograph/aluminum-acetate.html	Curative		Approved 8429	DOMEBORO Approved Use This medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection.

PubMed

Title	Date	PubMed
The ineffectiveness of aluminum subacetate in rheumatoid arthritis.	1948 Apr 8	18911341
The antibacterial activity of acetic acid and Burow's solution as topical otological preparations.	1998 Oct	10211213
Effect of aluminum phosphide on blood glucose level.	1999 Feb	9949483
Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study.	1999 May	10327022
Aluminum as a toxicant.	2002 Aug	15068131
[Pharmaceutical and pharmacological evaluation of Burow's solution (aluminum acetate solution), hospital preparation, and development of its rapid preparation method].	2004 Nov	15516810
Aluminum and Alzheimer's disease, a personal perspective after 25 years.	2006	17004365
Some aspects of astroglial functions and aluminum implications for neurodegeneration.	2006 Aug 30	16529821
An effector domain mutant of Arf6 implicates phospholipase D in endosomal membrane recycling.	2006 Jan	16280360
Aluminum and other metals in Alzheimer's disease: a review of potential therapy with chelating agents.	2006 Nov	17119296
Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer's disease.	2006 Nov	17119283
Ototoxic effect of Burow solution applied to the guinea pig middle ear.	2007 Aug	17450104
Retrospective analysis of 4-week inhalation studies in rats with focus on fate and pulmonary toxicity of two nanosized aluminum oxyhydroxides (boehmite) and pigment-grade iron oxide (magnetite): the key metric of dose is particle mass and not particle surface area.	2009 May 17	19428954
Altered glucose homeostasis in response to aluminium phosphide induced cellular oxygen deficit in rat.	2010 Jul	20929055
Molecular basis of carcinogenicity of tungsten alloy particles.	2015 Mar 15	25620057

Patents

Sample Use Guides

In Vivo Use Guide

DOMEBORO® SOOTHING SOAK – dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water – stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use For use as a soak: – soak affected area for 15 to 30 minutes as needed, or as directed by a doctor – repeat 3 times a day or as directed by a doctor – discard solution after each use. For use as a compress or wet dressing: – soak a clean, soft cloth in the solution. – apply cloth loosely to affected area for 15 to 30 minutes – repeat as needed or as directed by a doctor – discard solution after each use

Route of Administration: Topical

In Vitro Use Guide

Burow's solution (13% aluminum subacetate) is active against S. aureus and P. aeruginosa, resulting in damage to the cell wall.

Name

Type

Language

ALUMINUM ZIRCONIUM OCTACHLOROHYDREX GLY

Official Name

English

ALUMINIUM ZIRCONIUM OCTACHLOROHYDREX GLYCINE COMPLEX

Common Name

English

ALUMINIUM ZIRCONIUM OCTACHLOROHYDREX GLY

Common Name

English

ALUMINUM ZIRCONIUM OCTACHLOROHYDREX GLY [INCI]

Common Name

English

ALUMINUM ZIRCONIUM OCTACHLOROHYDREX GLYCINE COMPLEX

Common Name

English

ALUMINUM ZIRCONIUM OCTACHLOROHYDREX GLY [USP MONOGRAPH]

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 350.10