Details
| Stereochemistry | UNKNOWN |
| Molecular Formula | C10H17NO2 |
| Molecular Weight | 183.2475 |
| Optical Activity | ( + ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC1(CC)C(=O)NCC(C)C1=O
InChI
InChIKey=SIDLZWOQUZRBRU-UHFFFAOYSA-N
InChI=1S/C10H17NO2/c1-4-10(5-2)8(12)7(3)6-11-9(10)13/h7H,4-6H2,1-3H3,(H,11,13)
Methyprylon (brand name Noludar) is a sedative agent, which used to treat insomnia. But then the drug was replaced in the market by another drugs with less side effects. The precise mechanism of action is not known, but was made suggestion, that methyprylon increases the effects of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the brain.
CNS Activity
Originator
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
5.62 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2866242 |
300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered: |
METHYPRYLON plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
74.75 mg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2866242 |
300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered: |
METHYPRYLON plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
9.2 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2866242 |
300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered: |
METHYPRYLON plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
Doses
| Dose | Population | Adverse events |
|---|---|---|
30 g single, oral Overdose Dose: 30 g Route: oral Route: single Dose: 30 g Co-administed with:: dimenhydrinate(one hundred 50-mg capsules) Sources: |
unhealthy, 36 years n = 1 Health Status: unhealthy Age Group: 36 years Sex: F Population Size: 1 Sources: |
Other AEs: Comatose... |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Comatose | 1 patient | 30 g single, oral Overdose Dose: 30 g Route: oral Route: single Dose: 30 g Co-administed with:: dimenhydrinate(one hundred 50-mg capsules) Sources: |
unhealthy, 36 years n = 1 Health Status: unhealthy Age Group: 36 years Sex: F Population Size: 1 Sources: |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Hypnotic efficacy of triazolam and methyprylon ininsomniac in-patients. | 1976 |
|
| Pharmacokinetics of methyprylon following a single oral dose. | 1985 Sep |
|
| Nonlinear elimination of methyprylon (noludar) in an overdosed patient: correlation of clinical effects with plasma concentration. | 1991 Aug |
Patents
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|---|---|---|---|---|
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Common Name | English | ||
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Systematic Name | English |
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P66Z3UR32T
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30590-00-2
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4162
Created by
admin on Sat Dec 16 10:40:59 GMT 2023 , Edited by admin on Sat Dec 16 10:40:59 GMT 2023
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SUBSTANCE RECORD
