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Details

Stereochemistry UNKNOWN
Molecular Formula C10H17NO2
Molecular Weight 183.2475
Optical Activity ( + )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of METHYPRYLON, (+)-

SMILES

CCC1(CC)C(=O)NCC(C)C1=O

InChI

InChIKey=SIDLZWOQUZRBRU-UHFFFAOYSA-N
InChI=1S/C10H17NO2/c1-4-10(5-2)8(12)7(3)6-11-9(10)13/h7H,4-6H2,1-3H3,(H,11,13)

HIDE SMILES / InChI

Molecular Formula C10H17NO2
Molecular Weight 183.2475
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Methyprylon (brand name Noludar) is a sedative agent, which used to treat insomnia. But then the drug was replaced in the market by another drugs with less side effects. The precise mechanism of action is not known, but was made suggestion, that methyprylon increases the effects of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the brain.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
NOLUDAR

Cmax

ValueDoseCo-administeredAnalytePopulation
5.62 mg/L
300 mg single, oral
METHYPRYLON plasma
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
74.75 mg × h/L
300 mg single, oral
METHYPRYLON plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
9.2 h
300 mg single, oral
METHYPRYLON plasma
Homo sapiens

Doses

AEs

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
300 mg once a day before bedtime.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
P66Z3UR32T
Record Status Validated (UNII)
Record Version