Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C18H22O2 |
| Molecular Weight | 270.3661 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC[C@H](O)[C@@]1(C)C=CC3=C4CCC(=O)C=C4CC[C@@]23[H]
InChI
InChIKey=MEHHPFQKXOUFFV-OWSLCNJRSA-N
InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h8-10,15-17,20H,2-7H2,1H3/t15-,16+,17+,18+/m1/s1
DescriptionCurator's Comment: description was created based on several sources, including:
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=de1d618f-7e27-4307-9330-0e1a2255ee95
http://www.wikidoc.org/index.php/Trenbolone
Curator's Comment: description was created based on several sources, including:
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=de1d618f-7e27-4307-9330-0e1a2255ee95
http://www.wikidoc.org/index.php/Trenbolone
Trenbolone is an anabolic steroid. It is used on livestock to increase muscle growth and appetite. Trenbolone compounds have a binding affinity for the androgen receptor three times as high as that of testosterone. Once metabolized, the drugs have the effect of increasing nitrogen uptake by muscles, leading to an increase in the rate of protein synthesis. It also has the secondary effects of stimulating appetite, reducing the amount of fat being deposited in the body, and decreasing the rate of catabolism. Short-term side effects include insomnia, high blood pressure, increased aggression, night sweats, and libido.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL1871 |
0.15 nM [Kd] | ||
Target ID: CHEMBL208 |
|||
Target ID: CHEMBL2034 |
53.0 nM [Kd] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Finaplix®-H Approved UseIncreases rate of weight gain and improves feed efficiency. Launch Date1987 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Rapid test by liquid chromatography/tandem mass spectrometry to evaluate equine urine reactivity towards 17beta-OH steroids. | 2006 |
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| Application of ecotoxicogenomics for studying endocrine disruption in vertebrates and invertebrates. | 2006 Apr |
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| Doping control analysis in human urine by liquid chromatography-electrospray ionization ion trap mass spectrometry for the Olympic Games Athens 2004: determination of corticosteroids and quantification of ephedrines, salbutamol and morphine. | 2006 Jul 28 |
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| Rapid screening of doping agents in human urine by vacuum MALDI-linear ion trap mass spectrometry. | 2007 Aug 1 |
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| Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds. | 2007 Dec 1 |
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| Immunotoxicity of trenbolone acetate in Japanese quail. | 2007 Jan |
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| Reproductive toxicity of trenbolone acetate in embryonically exposed Japanese quail. | 2007 Jan |
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| Determination of synthetic hormones in animal urine by high-performance liquid chromatography/mass spectrometry. | 2007 Mar-Apr |
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| The OECD program to validate the rat Hershberger bioassay to screen compounds for in vivo androgen and antiandrogen responses: phase 2 dose-response studies. | 2007 May |
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| Analysis of synthetic 19-norsteroids trenbolone, tetrahydrogestrinone and gestrinone by gas chromatography-mass spectrometry. | 2007 May 25 |
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| In utero exposure to the environmental androgen trenbolone masculinizes female Sprague-Dawley rats. | 2007 Nov 1 |
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| A league of their own: demographics, motivations and patterns of use of 1,955 male adult non-medical anabolic steroid users in the United States. | 2007 Oct 11 |
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| Determination of anabolic steroids in muscle tissue by liquid chromatography-tandem mass spectrometry. | 2007 Oct 17 |
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| Evaluation of the rodent Hershberger bioassay: testing of coded chemicals and supplementary molecular-biological and biochemical investigations. | 2007 Sep 24 |
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| Screening of in vitro synthesised metabolites of 4,9,11-trien-3-one steroids by liquid chromatography mass spectrometry. | 2008 |
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| Induction of micronuclei in V79 cells by the anabolic doping steroids tetrahydrogestrinone and trenbolone. | 2008 Apr |
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| Chemical contaminants in feedlot wastes: concentrations, effects and attenuation. | 2008 Aug |
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| Identification of hormone esters in injection site in muscle tissues by LC/MS/MS. | 2008 Dec |
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| Intercalibration exercise using a stickleback endocrine disrupter screening assay. | 2008 Feb |
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| [Determination of three anabolic steroids by liquid chromatography-mass spectrometry]. | 2008 Jul |
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| Effect of parental exposure to trenbolone and the brominated flame retardant BDE-47 on fertility in rainbow trout (Oncorhynchus mykiss). | 2008 Jul |
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| Confirmatory analysis of Trenbolone using accurate mass measurement with LC/TOF-MS. | 2008 Jun 16 |
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| Comparison of estrogen-responsive plasma protein biomarkers and reproductive endpoints in sheepshead minnows exposed to 17beta-trenbolone. | 2008 Jun 23 |
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| Trace analysis of androgens and progestogens in environmental waters by ultra-performance liquid chromatography-electrospray tandem mass spectrometry. | 2008 Jun 27 |
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| The detection and assessment of the aneugenic potential of selected oestrogens, progestins and androgens using the in vitro cytokinesis blocked micronucleus assay. | 2008 Mar 12 |
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| Degradation of synthetic androgens 17alpha- and 17beta-trenbolone and trendione in agricultural soils. | 2008 May 15 |
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| Distribution of trenbolone residues in liver and various muscle groups of heifers that received multiple implants at the recommended site of application. | 2008 May-Jun |
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| [Determination of eleven steroid hormones in animal muscle tissues and eggs using ultra-performance liquid chromatography-tandem mass spectrometry]. | 2008 Nov |
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| The development of multiple drug use among anabolic-androgenic steroid users: six subjective case reports. | 2008 Nov 28 |
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| Determination of trenbolone residual in bovine liver by liquid chromatography-mass spectrometry. | 2009 Apr |
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| Expression signatures for a model androgen and antiandrogen in the fathead minnow (Pimephales promelas) ovary. | 2009 Apr 1 |
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| Stereoselective sorption by agricultural soils and liquid-liquid partitioning of trenbolone (17alpha and 17beta) and trendione. | 2009 Dec 1 |
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| The watershed as a conceptual framework for the study of environmental and human health. | 2009 Feb 18 |
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| Synthesis and SAR study of novel pseudo-steroids as potent and selective progesterone receptor antagonists. | 2009 Jul 15 |
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| Doping control analysis of trenbolone and related compounds using liquid chromatography-tandem mass spectrometry. | 2009 Mar |
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| Confirmatory method for the determination of nandrolone and trenbolone in urine samples using immunoaffinity cleanup and liquid chromatography-tandem mass spectrometry. | 2009 Nov 13 |
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| Analysis of anabolic steroids in hair: time courses in guinea pigs. | 2009 Sep |
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| Is the gonadotropin releasing hormone system vulnerable to endocrine disruption in birds? | 2009 Sep 1 |
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| Hormonal growth promoting agents in food producing animals. | 2010 |
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| Gonadal alterations in male eelpout (Zoarces viviparus) exposed to ethinylestradiol and trenbolone separately or in combination. | 2010 |
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| In vitro study of Organization for Economic Co-operation and Development (OECD) endocrine disruptor screening and testing methods- establishment of a recombinant rat androgen receptor (rrAR) binding assay. | 2010 Apr |
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| Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories. | 2010 Apr |
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| Synthesis and characterization of new aromatic esters based on 4,16-pregnadiene-6,20-dione skeleton. | 2010 Dec 8 |
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| Highly active human pharmaceuticals in aquatic systems: A concept for their identification based on their mode of action. | 2010 Feb 18 |
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| Sex differences in the uptake and disposition of perfluorooctanoic acid in fathead minnows after oral dosing. | 2010 Jan 1 |
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| Trenbolone causes irreversible masculinization of zebrafish at environmentally relevant concentrations. | 2010 Jul 15 |
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| Tissue selectivity and potential clinical applications of trenbolone (17beta-hydroxyestra-4,9,11-trien-3-one): A potent anabolic steroid with reduced androgenic and estrogenic activity. | 2010 Jun |
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| Soil temperature and moisture effects on the persistence of synthetic androgen 17alpha-trenbolone, 17beta-trenbolone and trendione. | 2010 May |
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| OECD validation of phase-3 Hershberger assay using the stimulated weanling male rat in Korea. | 2010 May |
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| Assessing the fate and transformation by-product potential of trenbolone during chlorination. | 2010 Nov |
Patents
Sample Use Guides
One implant containing 200 mg trenbolone acetate is administered to each animal. The implant is placed under the skin on the posterior aspect of the ear by means of a special implanter.
Route of Administration:
Other
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WIKIPEDIA |
Designer-drugs-Trenbolone
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CFR |
21 CFR 556.739
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NCI_THESAURUS |
C2360
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DEA NO. |
4000
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2916
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SUB11232MIG
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25015
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1484278
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P53R4420TR
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P53R4420TR
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TRENBOLONE
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100000077481
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m11015
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DTXSID0034192
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DB11551
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10161-33-8
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CHEMBL1698011
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C95072
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ACTIVE MOIETY
METABOLITE INACTIVE (PARENT)
