TRENBOLONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C18H22O2
Molecular Weight	270.3661
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@H](O)[C@@]1(C)C=CC3=C4CCC(=O)C=C4CC[C@@]23[H]

InChI

InChIKey=MEHHPFQKXOUFFV-OWSLCNJRSA-N

InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h8-10,15-17,20H,2-7H2,1H3/t15-,16+,17+,18+/m1/s1

HIDE SMILES / InChI

Description
Sources: https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/221
Curator's Comment: description was created based on several sources, including: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=de1d618f-7e27-4307-9330-0e1a2255ee95 http://www.wikidoc.org/index.php/Trenbolone

Trenbolone is an anabolic steroid. It is used on livestock to increase muscle growth and appetite. Trenbolone compounds have a binding affinity for the androgen receptor three times as high as that of testosterone. Once metabolized, the drugs have the effect of increasing nitrogen uptake by muscles, leading to an increase in the rate of protein synthesis. It also has the secondary effects of stimulating appetite, reducing the amount of fat being deposited in the body, and decreasing the rate of catabolism. Short-term side effects include insomnia, high blood pressure, increased aggression, night sweats, and libido.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Androgen Receptor 167 Target ID: CHEMBL1871 Sources: http://www.ncbi.nlm.nih.gov/pubmed/11252818	Binding Agent 1064	0.15 nM [Kd]
Progesterone receptor 61 Target ID: CHEMBL208 Sources: http://www.ncbi.nlm.nih.gov/pubmed/11252818	Binding Agent 1064
Glucocorticoid receptor 172 Target ID: CHEMBL2034 Sources: http://www.ncbi.nlm.nih.gov/pubmed/3486322	Binding Agent 1064	53.0 nM [Kd]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Weight gain 4 Sources: http://www.accessdata.fda.gov/spl/data/d1f62758-6d8f-40df-8e6c-d7377f1fbd1e/d1f62758-6d8f-40df-8e6c-d7377f1fbd1e.xml	Primary		Approved 8429	Finaplix®-H Approved Use Increases rate of weight gain and improves feed efficiency. Launch Date 1987

PubMed

Title	Date	PubMed
Assessment of oestrogenic potency of chemicals used as growth promoter by in-vitro methods.	2001 May	11331656
In vitro and in vivo effects of 17beta-trenbolone: a feedlot effluent contaminant.	2002 Dec	12441365
Fluctuating asymmetry and growth as biomarkers for exposure to androgen disrupting chemicals in Japanese quail.	2005 Aug	16215698
Evaluation of the rodent Hershberger bioassay using three reference (anti)androgens.	2005 Jun	15968828
Doping control analysis in human urine by liquid chromatography-electrospray ionization ion trap mass spectrometry for the Olympic Games Athens 2004: determination of corticosteroids and quantification of ephedrines, salbutamol and morphine.	2006 Jul 28	17723530
Determination of anabolic steroids in muscle tissue by liquid chromatography-tandem mass spectrometry.	2007 Oct 17	17887801
Screening of in vitro synthesised metabolites of 4,9,11-trien-3-one steroids by liquid chromatography mass spectrometry.	2008	18708698
Confirmatory analysis of Trenbolone using accurate mass measurement with LC/TOF-MS.	2008 Jun 16	18501249
The development of multiple drug use among anabolic-androgenic steroid users: six subjective case reports.	2008 Nov 28	19040748
Confirmatory method for the determination of nandrolone and trenbolone in urine samples using immunoaffinity cleanup and liquid chromatography-tandem mass spectrometry.	2009 Nov 13	19447393
Analysis of anabolic steroids in hair: time courses in guinea pigs.	2009 Sep	19397917

Patents

Sample Use Guides

In Vivo Use Guide

One implant containing 200 mg trenbolone acetate is administered to each animal. The implant is placed under the skin on the posterior aspect of the ear by means of a special implanter.

Route of Administration: Other

In Vitro Use Guide

Trenbolone was a high-affinity ligand for the androgen receptor (AR), with an IC(50) of about 4 nM in rat ventral prostate cytosol and about 33 nM in cells transfected with the human AR.

Name

Type

Language

TRENBOLONE

Official Name

English

TRENBOLONE [MI]

Common Name

English

RU-2341

Code

English

TRENBOLONE RELATED COMPOUND B [USP IMPURITY]

Common Name

English

Trenbolone [WHO-DD]

Common Name

English

TRENBOLONE RELATED COMPOUND B

Common Name

English

17BETA-TRENBOLONE

Common Name

English

ESTRA-4,9,11-TRIEN-3-ONE, 17-HYDROXY-, (17.BETA.)-

Systematic Name

English

TRIENBOLONE

Common Name

English

trenbolone [INN]

Common Name

English

Classification Tree Code System Code

WIKIPEDIA

Designer-drugs-Trenbolone