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Details

Stereochemistry ACHIRAL
Molecular Formula Be
Molecular Weight 9.012182
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BERYLLIUM

SMILES

[Be]

InChI

InChIKey=RWASOQSEFLDYLC-UHFFFAOYSA-N
InChI=1S/Be.2H

HIDE SMILES / InChI
Beryllium is a chemical element in the periodic table that has the symbol Be and atomic number 4. A toxic bivalent element, beryllium is a steel grey, strong, light-weight yet brittle, alkaline earth metal. Beryllium is an ubiquitous element in the environment, and it has many commercial applications. Beryllium is used in alloys with copper or nickel to make gyroscopes, springs, electrical contacts, spot-welding electrodes and non-sparking tools. Mixing beryllium with these metals increases their electrical and thermal conductivity. Other beryllium alloys are used as structural materials for high-speed aircraft, missiles, spacecraft and communication satellites. Beryllium is relatively transparent to X-rays so ultra-thin beryllium foil is finding use in X-ray lithography. Beryllium is also used in nuclear reactors as a reflector or moderator of neutrons. Beryllium and its compounds are toxic and carcinogenic. If beryllium dust or fumes are inhaled, it can lead to an incurable inflammation of the lungs called berylliosis. Because it is strong, stable, can handle elevated levels of heat resistance and is highly transparent to x-rays, beryllium, in thin foil form, has long been critical to the operation of medical and scientific x-ray equipment. Beryllium foil provides the window through which tissue-penetrating x-rays are focused, while maintaining the vacuum inside the x-ray tube generator. Beryllium foil remains indispensible for high-resolution medical radiography, including CT scanning and mammography. Beryllium in newer generation mammography equipment enables a lower radiation dose scan with significantly finer tumor resolution, enabling breast cancer detection at its early, most treatable stages. Beryllium is also used in components of the analytical equipment used to analyze blood for HIV and other diseases, offering the precision and reliability that doctors and patients demand.

Approval Year

PubMed

PubMed

TitleDatePubMed
Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease.
2013-07-01
Genetic variability in susceptibility to occupational respiratory sensitization.
2011
Metal ions in human cancer development.
2011
Metal ions affecting the skin and eyes.
2011
Crystal structure of HLA-DP2 and implications for chronic beryllium disease.
2010-04-20
Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells.
2009-09
Progression from beryllium exposure to chronic beryllium disease: an analytic model.
2009-06
Genetic determinants of sensitivity to beryllium in mice.
2009-06
4-1BB enhances proliferation of beryllium-specific T cells in the lung of subjects with chronic beryllium disease.
2008-09-15
A model of phenotypic susceptibility to tuberculosis: deficient in silico selection of Mycobacterium tuberculosis epitopes by HLA alleles.
2008-09
Impact of negatively charged patches on the surface of MHC class II antigen-presenting proteins on risk of chronic beryllium disease.
2008-07-06
Recombinant HLA-DP2 binds beryllium and tolerizes beryllium-specific pathogenic CD4+ T cells.
2006-09-15
The association between HLA-DPB1Glu69 and chronic beryllium disease and beryllium sensitization.
2004-08
Analysis of TNF-alpha promoter polymorphisms in the susceptibility to beryllium hypersensitivity.
2004-03
HLA-DP-unrestricted TNF-alpha release in beryllium-stimulated peripheral blood mononuclear cells.
2002-11
Human leukocyte antigen Class II amino acid epitopes: susceptibility and progression markers for beryllium hypersensitivity.
2002-03-15
Aberrant CpG island methylation of the p16(INK4a) and estrogen receptor genes in rat lung tumors induced by particulate carcinogens.
2002-02
Beryllium sensitivity is linked to HLA-DP genotype.
2001-08-13
HLA-DP allele-specific T cell responses to beryllium account for DP-associated susceptibility to chronic beryllium disease.
2001-03-01
Carcinogenic responses of transgenic heterozygous p53 knockout mice to inhaled 239PuO2 or metallic beryllium.
1998-08-26
Alterations in the K-ras and p53 genes in rat lung tumors.
1997-06
Chronic granulomatous pneumonia and lymphocytic responses induced by inhaled beryllium metal in A/J and C3H/HeJ mice.
1997-01-01
Animal models of beryllium-induced lung disease.
1996-10
Tumor necrosis factor alpha gene expression in human monocytic THP-1 cells exposed to beryllium.
1996-01-01
Analysis of K-ras, p53 and c-raf-1 mutations in beryllium-induced rat lung tumors.
1994-02
Maintenance of alveolitis in patients with chronic beryllium disease by beryllium-specific helper T cells.
1989-04-27
Abolition of natural tolerance and the influence of the chemical allergen beryllium on autoimmune processes.
1974
Patents

Sample Use Guides

The incorporation of thymidine into DNA of regenerating rat liver was measured at various times after partial hepatectomy. A single intravenous injection of 30 umol of beryllium/kg given immediately after the operation inhibited DNA synthesis 12, 16, 20, 24 and 28h later.
Route of Administration: Intravenous
Name Type Language
BERYLLIUM
MI  
Systematic Name English
BERYLLIUM METALLICUM
HPUS  
Preferred Name English
BE
Code English
BERYLLIUM [MI]
Common Name English
GLUCINIUM
Common Name English
BERYLLIUM AND BERYLLIUM COMPOUNDS [IARC]
Common Name English
BERYLLIUM, ELEMENTAL
HSDB  
Common Name English
BERYLLIUM-9
Common Name English
Beryllium [WHO-DD]
Common Name English
BERYLLIUM METALLICUM [HPUS]
Common Name English
BERYLLIUM, ELEMENTAL [HSDB]
Common Name English
Classification Tree Code System Code
DSLD 239 (Number of products:23)
Created by admin on Mon Mar 31 18:16:09 GMT 2025 , Edited by admin on Mon Mar 31 18:16:09 GMT 2025
NCI_THESAURUS C45383
Created by admin on Mon Mar 31 18:16:09 GMT 2025 , Edited by admin on Mon Mar 31 18:16:09 GMT 2025
NCI_THESAURUS C637
Created by admin on Mon Mar 31 18:16:09 GMT 2025 , Edited by admin on Mon Mar 31 18:16:09 GMT 2025
LOINC 76654-3
Created by admin on Mon Mar 31 18:16:09 GMT 2025 , Edited by admin on Mon Mar 31 18:16:09 GMT 2025
Code System Code Type Description
CHEBI
33783
Created by admin on Mon Mar 31 18:16:09 GMT 2025 , Edited by admin on Mon Mar 31 18:16:09 GMT 2025
PRIMARY
PUBCHEM
5460467
Created by admin on Mon Mar 31 18:16:09 GMT 2025 , Edited by admin on Mon Mar 31 18:16:09 GMT 2025
PRIMARY
SMS_ID
300000053148
Created by admin on Mon Mar 31 18:16:09 GMT 2025 , Edited by admin on Mon Mar 31 18:16:09 GMT 2025
PRIMARY
ECHA (EC/EINECS)
231-150-7
Created by admin on Mon Mar 31 18:16:09 GMT 2025 , Edited by admin on Mon Mar 31 18:16:09 GMT 2025
PRIMARY
MERCK INDEX
m2433
Created by admin on Mon Mar 31 18:16:09 GMT 2025 , Edited by admin on Mon Mar 31 18:16:09 GMT 2025
PRIMARY Merck Index
CHEBI
30501
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PRIMARY
NCI_THESAURUS
C44338
Created by admin on Mon Mar 31 18:16:09 GMT 2025 , Edited by admin on Mon Mar 31 18:16:09 GMT 2025
PRIMARY
CAS
7440-41-7
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PRIMARY
FDA UNII
OW5102UV6N
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PRIMARY
MESH
D001608
Created by admin on Mon Mar 31 18:16:09 GMT 2025 , Edited by admin on Mon Mar 31 18:16:09 GMT 2025
PRIMARY
EPA CompTox
DTXSID4023913
Created by admin on Mon Mar 31 18:16:09 GMT 2025 , Edited by admin on Mon Mar 31 18:16:09 GMT 2025
PRIMARY
CHEBI
52628
Created by admin on Mon Mar 31 18:16:09 GMT 2025 , Edited by admin on Mon Mar 31 18:16:09 GMT 2025
PRIMARY
WIKIPEDIA
Beryllium
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PRIMARY
HSDB
512
Created by admin on Mon Mar 31 18:16:09 GMT 2025 , Edited by admin on Mon Mar 31 18:16:09 GMT 2025
PRIMARY
RXCUI
1310252
Created by admin on Mon Mar 31 18:16:09 GMT 2025 , Edited by admin on Mon Mar 31 18:16:09 GMT 2025
PRIMARY RxNorm
DAILYMED
OW5102UV6N
Created by admin on Mon Mar 31 18:16:09 GMT 2025 , Edited by admin on Mon Mar 31 18:16:09 GMT 2025
PRIMARY