PROPENZOLATE

Details

Stereochemistry	EPIMERIC
Molecular Formula	C20H29NO3
Molecular Weight	331.4492
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCC[C@H](C1)OC(=O)C(O)(C2CCCCC2)C3=CC=CC=C3

InChI

InChIKey=LCFBCKSQWVQIBY-QSVWIEALSA-N

InChI=1S/C20H29NO3/c1-21-14-8-13-18(15-21)24-19(22)20(23,16-9-4-2-5-10-16)17-11-6-3-7-12-17/h2,4-5,9-10,17-18,23H,3,6-8,11-15H2,1H3/t18-,20?/m1/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6079700 | https://www.ncbi.nlm.nih.gov/pubmed/13885723

Propenzolate is a pyridine derivative patented by National Research Development Corp. as an anticholinergic agent. Propenzolate is effective antidotes to the cholinesterase-inhibiting action of various organophosphorus compounds. In clinical trials, Propenzolate has an activity that decreases to some extent the secretion of hydrochloric acid and the volume of gastric juice. Adverse effects, including nausea, vomiting, weakness, and drowsiness, as well as xerostomia and cycloplegia, are observed in a high percentage of patients receiving 0.5 to 1.0 mg. every 12 hours.

Originator

Approval Year

PubMed

Title	Date	PubMed
Gastrointestinal motility in man: a study of propenzolate.	1967 Sep	6079700

Patents

Sample Use Guides

In Vivo Use Guide

0.5 to 1.0 mg. every 12 hours.

Route of Administration: Oral

Name

Type

Language

PROPENZOLATE

Common Name

English

OXYCLIPINE

Official Name

English

(+)-1-METHYL-3-PIPERIDYL (±)-.ALPHA.-PHENYLCYCLOHEXANEGLYCOLATE

Systematic Name

English

PROPENZOLATE [MI]

Common Name

English

BENZENEACETIC ACID, .ALPHA.-CYCLOHEXYL-.ALPHA.-HYDROXY-, (±)-, (+)-1-METHYL-3-PIPERIDINYL ESTER

Common Name

English

oxyclipine [INN]

Common Name

English

Code System Code Type Description

SMS_ID

100000083301