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Details

Stereochemistry ACHIRAL
Molecular Formula C15H15N3O
Molecular Weight 253.2991
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PREMAZEPAM

SMILES

CN1C=C2NC(=O)CN=C(C2=C1C)C3=CC=CC=C3

InChI

InChIKey=CNWSHOJSFGGNLC-UHFFFAOYSA-N
InChI=1S/C15H15N3O/c1-10-14-12(9-18(10)2)17-13(19)8-16-15(14)11-6-4-3-5-7-11/h3-7,9H,8H2,1-2H3,(H,17,19)

HIDE SMILES / InChI

Description

Premazepam is a pyrrolodiazepine derivative patented by Gruppi Lepetit S.p.A. as a muscle relaxant. Premazepam is a partial agonist of benzodiazepine receptors and was shown in 1984 to possess both anxiolytic and sedative properties in humans. Premazepam had a different EEG profile from diazepam, producing slower and less fast wave activity. In the single dose study, its effects were similar to diazepam for sedative action and most of the psychological tests, with a tendency towards greater psychomotor impairment. In the repeated dose study, however, premazepam caused less sedation and also tended to produce less psychomotor impairment.

Originator

Approval Year

PubMed

Sample Use Guides

In Vivo Use Guide
5 and 10 mg twice-daily
Route of Administration: Oral