Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C5H3ClN4 |
| Molecular Weight | 154.557 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=NC=NC2=C1N=CN2
InChI
InChIKey=ZKBQDFAWXLTYKS-UHFFFAOYSA-N
InChI=1S/C5H3ClN4/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H,7,8,9,10)
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Purine analogs as potential anticytomegalovirus agents. | 1969 Sep |
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| Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii. | 1995 Nov 9 |
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| Synthesis and characterization of nucleosides and oligonucleotides bearing adducts of butadiene epoxides on adenine n(6) and guanine n(2). | 2001 Apr |
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| 5'-O-alkyl ethers of N,2-substituted adenosine derivatives: partial agonists for the adenosine A1 and A3 receptors. | 2001 Aug 30 |
|
| Molecular design of a new class of spin-labeled ribonucleosides with N-tert-butylaminoxyl radicals. | 2001 May 18 |
|
| Synthesis of base substituted 2-hydroxy-3-(purin-9-yl)-propanoic acids and 4-(purin-9-yl)-3-butenoic acids. | 2003 Dec |
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| A new method for the synthesis of 2'-O-benzyladenosine using Mitsunobu reaction. | 2003 Feb |
|
| Introduction of a benzyl group onto the 2'-OH of 6-chloropurine 3'-O-benzoylriboside. | 2003 May-Aug |
|
| Synthesis and Ca2+-mobilizing activity of purine-modified mimics of adenophostin A: a model for the adenophostin-Ins(1,4,5)P3 receptor interaction. | 2003 Nov 6 |
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| [Synthesis and biological activity of pseudonucleotides based on the evolution hypothesis of the glycocomponent of nucleic acid]. | 2003 Sep 1 |
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| Asymmetric synthesis of novel thioiso dideoxynucleosides with exocyclic methylene as potential antiviral agents. | 2004 Apr 30 |
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| SNAr iodination of 6-chloropurine nucleosides: aromatic Finkelstein reactions at temperatures below -40 degrees C. | 2004 Aug 19 |
|
| A novel synthesis of malondialdehyde adducts of deoxyguanosine, deoxyadenosine, and deoxycytidine. | 2004 Feb |
|
| Synthesis and biological evaluation of disubstituted N6-cyclopentyladenine analogues: the search for a neutral antagonist with high affinity for the adenosine A1 receptor. | 2004 Jan 2 |
|
| Transition-metal-mediated synthesis of novel carbocyclic nucleoside analogues with antitumoral activity. | 2004 Oct 11 |
|
| Microwave-assisted amination of a chloropurine derivative in the synthesis of acyclic nucleoside analogues. | 2005 Feb 28 |
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| Synthesis of novel 4'-carbon-substituted BCA derivatives based on radical cyclization. | 2006 |
|
| Anti-SARS-CoV activity of nucleoside analogs having 6-chloropurine as a nucleobase. | 2006 |
|
| Synthesis of fluorinated nucleosides. | 2006 Jul |
|
| Synthesis and anti-HCV activity Of 2''-beta-hydroxymethylated nucleosides. | 2007 |
|
| Suppression of subgenomic hepatitis C virus replication by 5'-O-masked analogues of 6-chloropurine-2'-deoxyriboside. | 2007 |
|
| Facile synthesis of 1',2'-cis-beta-pyranosyladenine nucleosides. | 2007 Dec 10 |
|
| Palladium-catalyzed cross-coupling reactions in c6 modifications of purine nucleosides. | 2007 Mar |
|
| A novel noninvasive method for assessing glutathione-conjugate efflux systems in the brain. | 2007 May 1 |
|
| Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents. | 2007 May 1 |
|
| Additive Pummerer reaction of 3,5-O-(di-tert-butyl)silylene-4-thiofuranoid glycal: a high-yield and beta-selective entry to 4'-thioribonucleosides. | 2009 Mar 20 |
|
| Synthesis of modified homo-N-nucleosides from the reactions of mesityl nitrile oxide with 9-allylpurines and their influence on lipid peroxidation and thrombin inhibition. | 2009 Nov 15 |
|
| Symmetrical and unsymmetrical alpha,omega-nucleobase amide-conjugated systems. | 2010 Apr 12 |
|
| Microwave-assisted syntheses of nucleosides and their precursors. | 2010 Feb |
|
| 15N and 13C NMR chemical shifts of 6-(fluoro, chloro, bromo, and iodo)purine 2'-deoxynucleosides: measurements and calculations. | 2010 Jan |
|
| Photochemical synthesis of nucleoside analogues from cyclobutanones: bicyclic and isonucleosides. | 2010 May 26 |
|
| Semisynthesis of 6-chloropurine-2'-deoxyriboside 5'-dimethoxytrityl 3'-(2-cyanoethyl-N,N-diisopropylamino)phosphoramidite and its use in the synthesis of fluorescently labeled oligonucleotides. | 2010 Nov |
|
| DNA oligomers containing site-specific and stereospecific exocyclic deoxyadenosine adducts of 1,2,3,4-diepoxybutane: synthesis, characterization, and effects on DNA structure. | 2010 Oct 18 |
|
| Direct synthesis of 6-arylpurines by reaction of 6-chloropurines with activated aromatics. | 2010 Sep 3 |
Patents
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87-42-3
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744
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5359277
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300000000020
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201-745-6
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m3433
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DTXSID00861673
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OH8700156W
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SUBSTANCE RECORD
