Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C5H3ClN4 |
| Molecular Weight | 154.557 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=NC=NC2=C1N=CN2
InChI
InChIKey=ZKBQDFAWXLTYKS-UHFFFAOYSA-N
InChI=1S/C5H3ClN4/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H,7,8,9,10)
| Molecular Formula | C5H3ClN4 |
| Molecular Weight | 154.557 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Semisynthesis of 6-chloropurine-2'-deoxyriboside 5'-dimethoxytrityl 3'-(2-cyanoethyl-N,N-diisopropylamino)phosphoramidite and its use in the synthesis of fluorescently labeled oligonucleotides. | 2010-11 |
|
| DNA oligomers containing site-specific and stereospecific exocyclic deoxyadenosine adducts of 1,2,3,4-diepoxybutane: synthesis, characterization, and effects on DNA structure. | 2010-10-18 |
|
| Direct synthesis of 6-arylpurines by reaction of 6-chloropurines with activated aromatics. | 2010-09-03 |
|
| Photochemical synthesis of nucleoside analogues from cyclobutanones: bicyclic and isonucleosides. | 2010-05-26 |
|
| Symmetrical and unsymmetrical alpha,omega-nucleobase amide-conjugated systems. | 2010-04-12 |
|
| Microwave-assisted syntheses of nucleosides and their precursors. | 2010-02 |
|
| 15N and 13C NMR chemical shifts of 6-(fluoro, chloro, bromo, and iodo)purine 2'-deoxynucleosides: measurements and calculations. | 2010-01 |
|
| Synthesis of modified homo-N-nucleosides from the reactions of mesityl nitrile oxide with 9-allylpurines and their influence on lipid peroxidation and thrombin inhibition. | 2009-11-15 |
|
| Kinetic analysis of base-pairing preference for nucleotide incorporation opposite template pyrimidines by human DNA polymerase iota. | 2009-06-05 |
|
| Identifying the features of purine dNTPs that allow accurate and efficient DNA replication by herpes simplex virus I DNA polymerase. | 2009-04-21 |
|
| Additive Pummerer reaction of 3,5-O-(di-tert-butyl)silylene-4-thiofuranoid glycal: a high-yield and beta-selective entry to 4'-thioribonucleosides. | 2009-03-20 |
|
| Activation of IP(3) receptors by synthetic bisphosphate ligands. | 2009-03-14 |
|
| Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives. | 2009-03-01 |
|
| Synthesis of 6,8,9-tri- and 2,6,8,9-tetrasubstituted purines by a combination of the Suzuki cross-coupling, N-arylation, and direct C-H arylation reactions. | 2008-11-21 |
|
| Neo-clinicians, clinical trials, and the reorganization of medical research in Paris hospitals after the Second World War: the trajectory of Jean Bernard. | 2008-10 |
|
| Bicyclic nucleoside synthesis: a photochemical approach. | 2008-05 |
|
| Facile synthesis of 1',2'-cis-beta-pyranosyladenine nucleosides. | 2007-12-10 |
|
| A novel noninvasive method for assessing glutathione-conjugate efflux systems in the brain. | 2007-05-01 |
|
| Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents. | 2007-05-01 |
|
| Palladium-catalyzed cross-coupling reactions in c6 modifications of purine nucleosides. | 2007-03 |
|
| Synthesis and anti-HCV activity Of 2''-beta-hydroxymethylated nucleosides. | 2007 |
|
| Suppression of subgenomic hepatitis C virus replication by 5'-O-masked analogues of 6-chloropurine-2'-deoxyriboside. | 2007 |
|
| A synthetic route to 9-(polyhydroxyalkyl)purines. | 2006-09-25 |
|
| Synthesis of fluorinated nucleosides. | 2006-07 |
|
| Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells. | 2006-02-01 |
|
| De novo asymmetric synthesis of homoadenosine via a palladium-catalyzed N-glycosylation. | 2006-01-19 |
|
| Synthesis of novel 4'-carbon-substituted BCA derivatives based on radical cyclization. | 2006 |
|
| Anti-SARS-CoV activity of nucleoside analogs having 6-chloropurine as a nucleobase. | 2006 |
|
| Traceless solid-phase synthesis of N1,N7-disubstituted purines. | 2005-09-13 |
|
| Cytostatic 6-arylpurine nucleosides. 6. SAR in anti-HCV and cytostatic activity of extended series of 6-hetarylpurine ribonucleosides. | 2005-09-08 |
|
| Preparation of a fully substituted purine library. | 2005-05-10 |
|
| The mechanism of selective purine C-nitration revealed: NMR studies demonstrate formation and radical rearrangement of an N7-nitramine intermediate. | 2005-04-27 |
|
| Evidence for Watson-Crick and not Hoogsteen or wobble base pairing in the selection of nucleotides for insertion opposite pyrimidines and a thymine dimer by yeast DNA pol eta. | 2005-03-29 |
|
| Microwave-assisted amination of a chloropurine derivative in the synthesis of acyclic nucleoside analogues. | 2005-02-28 |
|
| The novel pyrimidine and purine derivatives of l-ascorbic acid: synthesis, one- and two-dimensional 1H and 13C NMR study, cytostatic and antiviral evaluation. | 2005-01-03 |
|
| Transition-metal-mediated synthesis of novel carbocyclic nucleoside analogues with antitumoral activity. | 2004-10-11 |
|
| Conformationally constrained purine mimics. Incorporation of adenine and guanine into spirocyclic nucleosides. | 2004-08-20 |
|
| SNAr iodination of 6-chloropurine nucleosides: aromatic Finkelstein reactions at temperatures below -40 degrees C. | 2004-08-19 |
|
| Asymmetric synthesis of novel thioiso dideoxynucleosides with exocyclic methylene as potential antiviral agents. | 2004-04-30 |
|
| A novel synthesis of malondialdehyde adducts of deoxyguanosine, deoxyadenosine, and deoxycytidine. | 2004-02 |
|
| Synthesis and biological evaluation of disubstituted N6-cyclopentyladenine analogues: the search for a neutral antagonist with high affinity for the adenosine A1 receptor. | 2004-01-02 |
|
| Molecular design of novel spin-labeled nucleosides directly attached base moiety. | 2004 |
|
| Synthesis of base substituted 2-hydroxy-3-(purin-9-yl)-propanoic acids and 4-(purin-9-yl)-3-butenoic acids. | 2003-12 |
|
| Synthesis and Ca2+-mobilizing activity of purine-modified mimics of adenophostin A: a model for the adenophostin-Ins(1,4,5)P3 receptor interaction. | 2003-11-06 |
|
| Introduction of a benzyl group onto the 2'-OH of 6-chloropurine 3'-O-benzoylriboside. | 2003-10-21 |
|
| [Synthesis and biological activity of pseudonucleotides based on the evolution hypothesis of the glycocomponent of nucleic acid]. | 2003-09-01 |
|
| The yeast ISN1 (YOR155c) gene encodes a new type of IMP-specific 5'-nucleotidase. | 2003-05-07 |
|
| A new method for the synthesis of 2'-O-benzyladenosine using Mitsunobu reaction. | 2003-02 |
|
| Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii. | 1995-11-09 |
|
| Purine analogs as potential anticytomegalovirus agents. | 1969-09 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 17:45:11 GMT 2025
by
admin
on
Mon Mar 31 17:45:11 GMT 2025
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| Record UNII |
OH8700156W
|
| Record Status |
Validated (UNII)
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| Record Version |
|
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OH8700156W
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