U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C23H26F3N3S
Molecular Weight 433.533
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CYCLOPHENAZINE

SMILES

FC(F)(F)C1=CC2=C(SC3=C(C=CC=C3)N2CCCN4CCN(CC4)C5CC5)C=C1

InChI

InChIKey=NPYDSZQCCSLZPP-UHFFFAOYSA-N
InChI=1S/C23H26F3N3S/c24-23(25,26)17-6-9-22-20(16-17)29(19-4-1-2-5-21(19)30-22)11-3-10-27-12-14-28(15-13-27)18-7-8-18/h1-2,4-6,9,16,18H,3,7-8,10-15H2

HIDE SMILES / InChI
Cyclophenazine is an antagonist of dopamine receptors, discovered by Eli Lilly. The drug is claimed to possess tranquilizing, anti-emetic action, and is able to potentiate the action of anticholinergic compounds in inhibiting the gastric secretion.

Approval Year

PubMed

PubMed

TitleDatePubMed
Central dopamine receptors mediating pergolide-induced elevation of serum corticosterone in rats. Characterization by the use of antagonists.
1984 Dec
Patents
Name Type Language
CYCLOPHENAZINE
Common Name English
10-(3-(4-CYCLOPROPYL-1-PIPERAZINYL)PROPYL)-2-(TRIFLUOROMETHYL)PHENOTHIAZINE
Systematic Name English
Ciclofenazine [WHO-DD]
Common Name English
10H-PHENOTHIAZINE, 10-(3-(4-CYCLOPROPYL-1-PIPERAZINYL)PROPYL)-2-(TRIFLUOROMETHYL)-
Systematic Name English
NSC-161436
Code English
ciclofenazine [INN]
Common Name English
CICLOFENAZINE
INN   WHO-DD  
INN  
Official Name English
Classification Tree Code System Code
NCI_THESAURUS C66885
Created by admin on Sat Dec 16 15:51:09 GMT 2023 , Edited by admin on Sat Dec 16 15:51:09 GMT 2023
NCI_THESAURUS C66883
Created by admin on Sat Dec 16 15:51:09 GMT 2023 , Edited by admin on Sat Dec 16 15:51:09 GMT 2023
Code System Code Type Description
NSC
161436
Created by admin on Sat Dec 16 15:51:09 GMT 2023 , Edited by admin on Sat Dec 16 15:51:09 GMT 2023
PRIMARY
ChEMBL
CHEMBL2110782
Created by admin on Sat Dec 16 15:51:09 GMT 2023 , Edited by admin on Sat Dec 16 15:51:09 GMT 2023
PRIMARY
EVMPD
SUB06241MIG
Created by admin on Sat Dec 16 15:51:09 GMT 2023 , Edited by admin on Sat Dec 16 15:51:09 GMT 2023
PRIMARY
EPA CompTox
DTXSID60170218
Created by admin on Sat Dec 16 15:51:09 GMT 2023 , Edited by admin on Sat Dec 16 15:51:09 GMT 2023
PRIMARY
SMS_ID
100000081887
Created by admin on Sat Dec 16 15:51:09 GMT 2023 , Edited by admin on Sat Dec 16 15:51:09 GMT 2023
PRIMARY
PUBCHEM
28690
Created by admin on Sat Dec 16 15:51:09 GMT 2023 , Edited by admin on Sat Dec 16 15:51:09 GMT 2023
PRIMARY
FDA UNII
OH4ZJ36RB2
Created by admin on Sat Dec 16 15:51:09 GMT 2023 , Edited by admin on Sat Dec 16 15:51:09 GMT 2023
PRIMARY
CAS
17692-26-1
Created by admin on Sat Dec 16 15:51:09 GMT 2023 , Edited by admin on Sat Dec 16 15:51:09 GMT 2023
PRIMARY
NCI_THESAURUS
C81097
Created by admin on Sat Dec 16 15:51:09 GMT 2023 , Edited by admin on Sat Dec 16 15:51:09 GMT 2023
PRIMARY
INN
2429
Created by admin on Sat Dec 16 15:51:09 GMT 2023 , Edited by admin on Sat Dec 16 15:51:09 GMT 2023
PRIMARY