CYCLOPHENAZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H26F3N3S
Molecular Weight	433.533
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC(F)(F)C1=CC=C2SC3=CC=CC=C3N(CCCN4CCN(CC4)C5CC5)C2=C1

InChI

InChIKey=NPYDSZQCCSLZPP-UHFFFAOYSA-N

InChI=1S/C23H26F3N3S/c24-23(25,26)17-6-9-22-20(16-17)29(19-4-1-2-5-21(19)30-22)11-3-10-27-12-14-28(15-13-27)18-7-8-18/h1-2,4-6,9,16,18H,3,7-8,10-15H2

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6527743 | https://patents.google.com/patent/US3342816A/en

Cyclophenazine is an antagonist of dopamine receptors, discovered by Eli Lilly. The drug is claimed to possess tranquilizing, anti-emetic action, and is able to potentiate the action of anticholinergic compounds in inhibiting the gastric secretion.

Originator

Approval Year

PubMed

Title	Date	PubMed
Central dopamine receptors mediating pergolide-induced elevation of serum corticosterone in rats. Characterization by the use of antagonists.	1984-12	6527743

Patents

Name

Type

Language

CYCLOPHENAZINE

Common Name

English

CICLOFENAZINE

Preferred Name

English

10-(3-(4-CYCLOPROPYL-1-PIPERAZINYL)PROPYL)-2-(TRIFLUOROMETHYL)PHENOTHIAZINE

Systematic Name

English

Ciclofenazine [WHO-DD]

Common Name

English

10H-PHENOTHIAZINE, 10-(3-(4-CYCLOPROPYL-1-PIPERAZINYL)PROPYL)-2-(TRIFLUOROMETHYL)-

Systematic Name

English

NSC-161436

Code

English

ciclofenazine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66885