CYCLOPHENAZINE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H26F3N3S
Molecular Weight	433.533
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

FC(F)(F)C1=CC=C2SC3=CC=CC=C3N(CCCN4CCN(CC4)C5CC5)C2=C1

InChI

InChIKey=NPYDSZQCCSLZPP-UHFFFAOYSA-N

InChI=1S/C23H26F3N3S/c24-23(25,26)17-6-9-22-20(16-17)29(19-4-1-2-5-21(19)30-22)11-3-10-27-12-14-28(15-13-27)18-7-8-18/h1-2,4-6,9,16,18H,3,7-8,10-15H2

HIDE SMILES / InChI

Description

Cyclophenazine is an antagonist of dopamine receptors, discovered by Eli Lilly. The drug is claimed to possess tranquilizing, anti-emetic action, and is able to potentiate the action of anticholinergic compounds in inhibiting the gastric secretion.

Originator

Approval Year

PubMed

Show entries

Title	Date	PubMed
Central dopamine receptors mediating pergolide-induced elevation of serum corticosterone in rats. Characterization by the use of antagonists.	1984 Dec	6527743

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Patents

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Name

Type

Language

CYCLOPHENAZINE

Common Name

English

CICLOFENAZINE

Preferred Name

English

10-(3-(4-CYCLOPROPYL-1-PIPERAZINYL)PROPYL)-2-(TRIFLUOROMETHYL)PHENOTHIAZINE

Systematic Name

English

Ciclofenazine [WHO-DD]

Common Name

English

10H-PHENOTHIAZINE, 10-(3-(4-CYCLOPROPYL-1-PIPERAZINYL)PROPYL)-2-(TRIFLUOROMETHYL)-

Systematic Name

English

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Classification Tree

Code System

Code

Agent Affecting Nervous System

NCI_THESAURUS

C66885

Agent Affecting Nervous System

NCI_THESAURUS

C66883

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Code System

Code

Type

Description

NSC

161436

PRIMARY

ChEMBL

CHEMBL2110782

PRIMARY

EVMPD

SUB06241MIG

PRIMARY

EPA CompTox

DTXSID60170218

PRIMARY

SMS_ID

100000081887

PRIMARY

Showing 1 to 5 of 10 entries

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ACTIVE MOIETY


					OH4ZJ36RB2

CYCLOPHENAZINE

SALT/SOLVATE (PARENT)


					H68VTK0LL9

CYCLOPHENAZINE HYDROCHLORIDE