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Details

Stereochemistry ACHIRAL
Molecular Formula C23H26F3N3S.2ClH
Molecular Weight 506.455
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CYCLOPHENAZINE HYDROCHLORIDE

SMILES

Cl.Cl.FC(F)(F)C1=CC2=C(SC3=C(C=CC=C3)N2CCCN4CCN(CC4)C5CC5)C=C1

InChI

InChIKey=PGFVMQPOOFLBBI-UHFFFAOYSA-N
InChI=1S/C23H26F3N3S.2ClH/c24-23(25,26)17-6-9-22-20(16-17)29(19-4-1-2-5-21(19)30-22)11-3-10-27-12-14-28(15-13-27)18-7-8-18;;/h1-2,4-6,9,16,18H,3,7-8,10-15H2;2*1H

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C23H26F3N3S
Molecular Weight 433.533
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Cyclophenazine is an antagonist of dopamine receptors, discovered by Eli Lilly. The drug is claimed to possess tranquilizing, anti-emetic action, and is able to potentiate the action of anticholinergic compounds in inhibiting the gastric secretion.

Originator

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Central dopamine receptors mediating pergolide-induced elevation of serum corticosterone in rats. Characterization by the use of antagonists.
1984 Dec
Patents

Patents

20040019030
4
20060018934
27
US3342816A
2
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:18:57 GMT 2023
Edited
by admin
on Fri Dec 15 15:18:57 GMT 2023
Record UNII
H68VTK0LL9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CYCLOPHENAZINE HYDROCHLORIDE
USAN  
USAN  
Official Name English
CYCLOPHENAZINE HCL
Common Name English
10-[3-(4-Cyclopropyl-1-piperazinyl)propyl]-2-(trifluoromethyl)phenothiazine dihydrochloride
Systematic Name English
CICLOFENAZINE HYDROCHLORIDE
Common Name English
10H-PHENOTHIAZINE, 10-(3-(4-CYCLOPROPYL-1-PIPERAZINYL)PROPYL)-2-(TRIFLUOROMETHYL)-, DIHYDROCHLORIDE
Common Name English
CYCLOPHENAZINE HYDROCHLORIDE [USAN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29710
Created by admin on Fri Dec 15 15:18:57 GMT 2023 , Edited by admin on Fri Dec 15 15:18:57 GMT 2023
Code System Code Type Description
CAS
15686-74-5
Created by admin on Fri Dec 15 15:18:57 GMT 2023 , Edited by admin on Fri Dec 15 15:18:57 GMT 2023
PRIMARY
ChEMBL
CHEMBL2110782
Created by admin on Fri Dec 15 15:18:57 GMT 2023 , Edited by admin on Fri Dec 15 15:18:57 GMT 2023
PRIMARY
PUBCHEM
168895
Created by admin on Fri Dec 15 15:18:57 GMT 2023 , Edited by admin on Fri Dec 15 15:18:57 GMT 2023
PRIMARY
FDA UNII
H68VTK0LL9
Created by admin on Fri Dec 15 15:18:57 GMT 2023 , Edited by admin on Fri Dec 15 15:18:57 GMT 2023
PRIMARY
NCI_THESAURUS
C81587
Created by admin on Fri Dec 15 15:18:57 GMT 2023 , Edited by admin on Fri Dec 15 15:18:57 GMT 2023
PRIMARY
Related Record Type Details
Structure of CYCLOPHENAZINE
PARENT -> SALT/SOLVATE
NIH
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