U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C18H18FN3.ClH
Molecular Weight 331.815
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CARVOTROLINE HYDROCHLORIDE

SMILES

Cl.FC1=CC2=C(NC3=C2CN(CCC4=CC=NC=C4)CC3)C=C1

InChI

InChIKey=CYAQJBUCOCJWET-UHFFFAOYSA-N
InChI=1S/C18H18FN3.ClH/c19-14-1-2-17-15(11-14)16-12-22(10-6-18(16)21-17)9-5-13-3-7-20-8-4-13;/h1-4,7-8,11,21H,5-6,9-10,12H2;1H

HIDE SMILES / InChI
Carvotroline [WY 47791] is a novel γ-carboline derivative with a preclinical profile suggestive of antipsychotic activity. Carvotroline has an affinity for the dopamine D2 receptor and cortical 5-HT2 receptor that is ten times greater than serotonin. Carvotroline administration to rats leads to a decrease of plasma corticosterone levels and demonstrated a moderating effect on the rotational-stress induced rise in plasma corticosterone levels.

Approval Year

PubMed

PubMed

TitleDatePubMed
Modification of hypothalamic-pituitary-adrenocortical activity by serotonergic agents in the rat.
1997 Aug
Patents

Patents

Sample Use Guides

rat 7.0 mg/kg
Route of Administration: Intraperitoneal
Name Type Language
CARVOTROLINE HYDROCHLORIDE
USAN   WHO-DD  
USAN  
Official Name English
Carvotroline hydrochloride [WHO-DD]
Common Name English
8-Fluoro-2,3,4,5-tetrahydro-2-[2-(4-pyridyl)ethyl]-1H-pyrido[4,3-b]indole monohydrochloride
Systematic Name English
1H-PYRIDO(4,3-B)INDOLE, 8-FLUORO-2,3,4,5-TETRAHYDRO-2-(2-(4-PYRIDINYL)ETHYL)-, MONOHYDROCHLORIDE
Common Name English
CARVOTROLINE HYDROCHLORIDE [USAN]
Common Name English
WY-47791 HCL
Code English
Code System Code Type Description
CAS
136777-43-0
Created by admin on Fri Dec 15 15:41:45 GMT 2023 , Edited by admin on Fri Dec 15 15:41:45 GMT 2023
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EPA CompTox
DTXSID00159926
Created by admin on Fri Dec 15 15:41:45 GMT 2023 , Edited by admin on Fri Dec 15 15:41:45 GMT 2023
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PUBCHEM
72037
Created by admin on Fri Dec 15 15:41:45 GMT 2023 , Edited by admin on Fri Dec 15 15:41:45 GMT 2023
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USAN
EE-22
Created by admin on Fri Dec 15 15:41:45 GMT 2023 , Edited by admin on Fri Dec 15 15:41:45 GMT 2023
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ChEMBL
CHEMBL300443
Created by admin on Fri Dec 15 15:41:45 GMT 2023 , Edited by admin on Fri Dec 15 15:41:45 GMT 2023
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FDA UNII
OGU53DND3M
Created by admin on Fri Dec 15 15:41:45 GMT 2023 , Edited by admin on Fri Dec 15 15:41:45 GMT 2023
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NCI_THESAURUS
C174800
Created by admin on Fri Dec 15 15:41:45 GMT 2023 , Edited by admin on Fri Dec 15 15:41:45 GMT 2023
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