CARVOTROLINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H18FN3.ClH
Molecular Weight	331.815
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.FC1=CC2=C(NC3=C2CN(CCC4=CC=NC=C4)CC3)C=C1

InChI

InChIKey=CYAQJBUCOCJWET-UHFFFAOYSA-N

InChI=1S/C18H18FN3.ClH/c19-14-1-2-17-15(11-14)16-12-22(10-6-18(16)21-17)9-5-13-3-7-20-8-4-13;/h1-4,7-8,11,21H,5-6,9-10,12H2;1H

HIDE SMILES / InChI

Molecular Formula	C18H18FN3
Molecular Weight	295.354
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9323305 | http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4636563.PN.&OS=PN/4636563&RS=PN/4636563

Carvotroline [WY 47791] is a novel γ-carboline derivative with a preclinical profile suggestive of antipsychotic activity. Carvotroline has an affinity for the dopamine D2 receptor and cortical 5-HT2 receptor that is ten times greater than serotonin. Carvotroline administration to rats leads to a decrease of plasma corticosterone levels and demonstrated a moderating effect on the rotational-stress induced rise in plasma corticosterone levels.

Originator

Approval Year

PubMed

Title	Date	PubMed
Modification of hypothalamic-pituitary-adrenocortical activity by serotonergic agents in the rat.	1997 Aug	9323305

Patents

Sample Use Guides

In Vivo Use Guide

rat 7.0 mg/kg

Route of Administration: Intraperitoneal

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:41:45 GMT 2023` Edited by `admin` on `Fri Dec 15 15:41:45 GMT 2023`
Record UNII	OGU53DND3M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CARVOTROLINE HYDROCHLORIDE

Official Name

English

Carvotroline hydrochloride [WHO-DD]

Common Name

English

8-Fluoro-2,3,4,5-tetrahydro-2-[2-(4-pyridyl)ethyl]-1H-pyrido[4,3-b]indole monohydrochloride

Systematic Name

English

1H-PYRIDO(4,3-B)INDOLE, 8-FLUORO-2,3,4,5-TETRAHYDRO-2-(2-(4-PYRIDINYL)ETHYL)-, MONOHYDROCHLORIDE

Common Name

English

CARVOTROLINE HYDROCHLORIDE [USAN]

Common Name

English

WY-47791 HCL

Code

English

Code System Code Type Description

CAS

136777-43-0