Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C30H40O6 |
Molecular Weight | 496.635 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 14 / 14 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC[C@](C)(O)[C@@]3([H])C([C@H]1OC(=O)[C@H]2C)=C(C)[C@@]4([H])[C@]3([H])[C@H]5C=C(C)[C@@]46[C@@]7([H])OC(=O)[C@@H](C)[C@]7([H])CC[C@](C)(O)[C@]56[H]
InChI
InChIKey=PZHWYURJZAPXAN-ILOFNVQHSA-N
InChI=1S/C30H40O6/c1-12-11-18-20-21(30(12)24(18)29(6,34)10-8-17-14(3)27(32)36-25(17)30)15(4)19-22(20)28(5,33)9-7-16-13(2)26(31)35-23(16)19/h11,13-14,16-18,20-25,33-34H,7-10H2,1-6H3/t13-,14-,16-,17-,18+,20-,21-,22-,23-,24-,25-,28-,29-,30+/m0/s1
Absinthin is a triterpene, extracted from a Chinese herb, with anti-inflammatory properties.Absinthin is a naturally produced molecule from the plant Artemisia absinthium (Wormwood). It constitutes one of the most bitter chemical agents responsible for Absinthe's distinct taste. Absinthin attenuates LPS-induced ALI through MIP-1α-mediated inflammatory cell infiltration. Absinthin is a promising novel therapeutic candidate for the treatment of ALI.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: O70138 Gene ID: 17394.0 Gene Symbol: Mmp8 Target Organism: Mus musculus (Mouse) Sources: https://www.ncbi.nlm.nih.gov/pubmed/26495959 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26495959
Mice were treated with various concentrations (20 mg/kg, 40 mg/kg, and 80mg/kg) of absinthin, and lipopolysaccharide (LPS) to induce ALI.
Route of Administration:
Unknown
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26495959
RAW264.7 macrophages were treated with absinthin (either 10 ug/ml, 50 ug/ml, or
100 ug/ml) plus lipopolysaccharide (LPS) (1 ug/ml), or with LPS alone, for 24 h.
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442138
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m1283
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ABSINTHIN
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OE5992O64P
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SUBSTANCE RECORD