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Details

Stereochemistry ABSOLUTE
Molecular Formula C30H40O6
Molecular Weight 496.635
Optical Activity UNSPECIFIED
Defined Stereocenters 14 / 14
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ABSINTHIN

SMILES

[H][C@@]12CC[C@](C)(O)[C@@]3([H])C([C@H]1OC(=O)[C@H]2C)=C(C)[C@@]4([H])[C@]3([H])[C@H]5C=C(C)[C@@]46[C@@]7([H])OC(=O)[C@@H](C)[C@]7([H])CC[C@](C)(O)[C@]56[H]

InChI

InChIKey=PZHWYURJZAPXAN-ILOFNVQHSA-N
InChI=1S/C30H40O6/c1-12-11-18-20-21(30(12)24(18)29(6,34)10-8-17-14(3)27(32)36-25(17)30)15(4)19-22(20)28(5,33)9-7-16-13(2)26(31)35-23(16)19/h11,13-14,16-18,20-25,33-34H,7-10H2,1-6H3/t13-,14-,16-,17-,18+,20-,21-,22-,23-,24-,25-,28-,29-,30+/m0/s1

HIDE SMILES / InChI
Absinthin is a triterpene, extracted from a Chinese herb, with anti-inflammatory properties.Absinthin is a naturally produced molecule from the plant Artemisia absinthium (Wormwood). It constitutes one of the most bitter chemical agents responsible for Absinthe's distinct taste. Absinthin attenuates LPS-induced ALI through MIP-1α-mediated inflammatory cell infiltration. Absinthin is a promising novel therapeutic candidate for the treatment of ALI.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: O70138
Gene ID: 17394.0
Gene Symbol: Mmp8
Target Organism: Mus musculus (Mouse)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Total synthesis of absinthin.
2005 Jan 12
Absinthe--a review.
2006
Women's health among the Chumash.
2006 Mar
Ultraviolet light absorption of an ophthalmic formulation with Aloe extracts.
2009 Sep
Patents

Patents

Sample Use Guides

Mice were treated with various concentrations (20 mg/kg, 40 mg/kg, and 80mg/kg) of absinthin, and lipopolysaccharide (LPS) to induce ALI.
Route of Administration: Unknown
RAW264.7 macrophages were treated with absinthin (either 10 ug/ml, 50 ug/ml, or 100 ug/ml) plus lipopolysaccharide (LPS) (1 ug/ml), or with LPS alone, for 24 h.
Name Type Language
ABSINTHIN
MI  
Common Name English
ABSYNTHIN
Common Name English
CHIEF BITTER PRINCIPLE OF ARTEMISIA ABSINTHIUM
Common Name English
(+)-ABSINTHIN
Common Name English
ABSINTHIN [MI]
Common Name English
NSC-407315
Code English
ABSINTHIIN
Common Name English
Code System Code Type Description
PUBCHEM
442138
Created by admin on Sat Dec 16 08:39:28 GMT 2023 , Edited by admin on Sat Dec 16 08:39:28 GMT 2023
PRIMARY
MERCK INDEX
m1283
Created by admin on Sat Dec 16 08:39:28 GMT 2023 , Edited by admin on Sat Dec 16 08:39:28 GMT 2023
PRIMARY Merck Index
CAS
1362-42-1
Created by admin on Sat Dec 16 08:39:28 GMT 2023 , Edited by admin on Sat Dec 16 08:39:28 GMT 2023
PRIMARY
WIKIPEDIA
ABSINTHIN
Created by admin on Sat Dec 16 08:39:28 GMT 2023 , Edited by admin on Sat Dec 16 08:39:28 GMT 2023
PRIMARY
CHEBI
2366
Created by admin on Sat Dec 16 08:39:28 GMT 2023 , Edited by admin on Sat Dec 16 08:39:28 GMT 2023
PRIMARY
NSC
407315
Created by admin on Sat Dec 16 08:39:28 GMT 2023 , Edited by admin on Sat Dec 16 08:39:28 GMT 2023
PRIMARY
EPA CompTox
DTXSID70929294
Created by admin on Sat Dec 16 08:39:28 GMT 2023 , Edited by admin on Sat Dec 16 08:39:28 GMT 2023
PRIMARY
FDA UNII
OE5992O64P
Created by admin on Sat Dec 16 08:39:28 GMT 2023 , Edited by admin on Sat Dec 16 08:39:28 GMT 2023
PRIMARY