ABSINTHIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C30H40O6
Molecular Weight	496.635
Optical Activity	UNSPECIFIED
Defined Stereocenters	14 / 14
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@](C)(O)[C@@]3([H])C([C@H]1OC(=O)[C@H]2C)=C(C)[C@@]4([H])[C@]3([H])[C@H]5C=C(C)[C@@]46[C@@]7([H])OC(=O)[C@@H](C)[C@]7([H])CC[C@](C)(O)[C@]56[H]

InChI

InChIKey=PZHWYURJZAPXAN-ILOFNVQHSA-N

InChI=1S/C30H40O6/c1-12-11-18-20-21(30(12)24(18)29(6,34)10-8-17-14(3)27(32)36-25(17)30)15(4)19-22(20)28(5,33)9-7-16-13(2)26(31)35-23(16)19/h11,13-14,16-18,20-25,33-34H,7-10H2,1-6H3/t13-,14-,16-,17-,18+,20-,21-,22-,23-,24-,25-,28-,29-,30+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C30H40O6
Molecular Weight	496.635
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	13 / 14
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26495959 | http://foodb.ca/compounds/FDB014471

Absinthin is a triterpene, extracted from a Chinese herb, with anti-inflammatory properties.Absinthin is a naturally produced molecule from the plant Artemisia absinthium (Wormwood). It constitutes one of the most bitter chemical agents responsible for Absinthe's distinct taste. Absinthin attenuates LPS-induced ALI through MIP-1α-mediated inflammatory cell infiltration. Absinthin is a promising novel therapeutic candidate for the treatment of ALI.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Neutrophil collagenase 2 Target ID: O70138 Gene ID: 17394.0 Gene Symbol: Mmp8 Target Organism: Mus musculus (Mouse) Sources: https://www.ncbi.nlm.nih.gov/pubmed/26495959	Activator 1430

Conditions

Condition	Modality	Targets	Highest Phase	Product
Acute lung injury 20 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26495959	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

Mice were treated with various concentrations (20 mg/kg, 40 mg/kg, and 80mg/kg) of absinthin, and lipopolysaccharide (LPS) to induce ALI.

Route of Administration: Unknown

In Vitro Use Guide

RAW264.7 macrophages were treated with absinthin (either 10 ug/ml, 50 ug/ml, or 100 ug/ml) plus lipopolysaccharide (LPS) (1 ug/ml), or with LPS alone, for 24 h.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:39:28 GMT 2023` Edited by `admin` on `Sat Dec 16 08:39:28 GMT 2023`
Record UNII	OE5992O64P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ABSINTHIN

Common Name

English

ABSYNTHIN

Common Name

English

CHIEF BITTER PRINCIPLE OF ARTEMISIA ABSINTHIUM

Common Name

English

(+)-ABSINTHIN

Common Name

English

ABSINTHIN [MI]

Common Name

English

NSC-407315

Code

English

ABSINTHIIN

Common Name

English

Code System Code Type Description

PUBCHEM

442138