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Details

Stereochemistry RACEMIC
Molecular Formula C36H41N3O6.ClH
Molecular Weight 648.188
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LERCANIDIPINE HYDROCHLORIDE

SMILES

Cl.COC(=O)C1=C(C)NC(C)=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC(C)(C)CN(C)CCC(C3=CC=CC=C3)C4=CC=CC=C4

InChI

InChIKey=WMFYOYKPJLRMJI-UHFFFAOYSA-N
InChI=1S/C36H41N3O6.ClH/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27;/h7-19,22,30,33,37H,20-21,23H2,1-6H3;1H

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including https://www.drugs.com/history/lercanidipine.html | https://www.ncbi.nlm.nih.gov/pubmed/27794423

Lercanidipine is antihypertensive drugs which acts by blocking L-type calcium channels, allowing relaxation and opening of blood vessels. Lercanidipine exists as a racemate, with anti-hypertensive activity residing primarily in S-enantiomer. NDA for lercanidipine was submitted to FDA in 2002 by Forest Laboratories, but FDA refused to approve the drug, and lercanidipine is not marketed in USA. Lercanidipine is also investigated in preclinical models of epilepsy and ischemic stroke.

CNS Activity

CNS Active
4002
Curator's Comment: Active in a preclinical models of epilepsy on mice

Originator

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Blocker
555
 2.2 nM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8583
ZANIDIP

Approved Use

Lercanidipine is indicated for the treatment of mild to moderate essential hypertension
Primary
Preclinical
Unknown

Approved Use

Unknown
Palliative
Preclinical
Unknown

Approved Use

Unknown
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
2.37 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/15556551/
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
LERCANIDIPINE, (S)- plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
1.68 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/15556551/
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
LERCANIDIPINE. (R)- plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
2.244 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/27405507/
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered: VALSARTAN
VALSARTAN
 LERCANIDIPINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
3.231 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/27232153/
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
LERCANIDIPINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
13.68 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/15556551/
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
LERCANIDIPINE, (S)- plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
11.24 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/15556551/
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
LERCANIDIPINE. (R)- plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
12.741 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/27405507/
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered: VALSARTAN
VALSARTAN
 LERCANIDIPINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
12.04 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/27232153/
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
LERCANIDIPINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
9.3 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/15556551/
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
LERCANIDIPINE, (S)- plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
7.5 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/15556551/
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
LERCANIDIPINE. (R)- plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
5.221 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/27405507/
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered: VALSARTAN
VALSARTAN
 LERCANIDIPINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
9.2 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/27232153/
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
LERCANIDIPINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
2%
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/15556551/
LERCANIDIPINE plasma
Homo sapiens
Doses

Doses

DosePopulationAdverse events​
560 mg single, oral
Overdose
Dose: 560 mg
Route: oral
Route: single
Dose: 560 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/21251326/
healthy, ADULT
Health Status: healthy
Age Group: ADULT
Sex: M
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/21251326/
Disc. AE: seizure, hypotension...
AEs leading to
discontinuation/dose reduction:
seizure (1 pt)
hypotension (1 pt)
bradycardia (1 pt)
Sources:
https://pubmed.ncbi.nlm.nih.gov/21251326/
10 mg 1 times / day steady-state, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady-state
Dose: 10 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/28485829/
unhealthy, ADULT
Health Status: unhealthy
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/28485829/
Other AEs: abdominal distension, dyspepsia...
Other AEs:
abdominal distension (1 pt)
dyspepsia (1 pt)
nausea (1 pt)
Sources:
https://pubmed.ncbi.nlm.nih.gov/28485829/
10 mg 1 times / day steady-state, oral
Studied dose
Dose: 10 mg, 1 times / day
Route: oral
Route: steady-state
Dose: 10 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/17581601/
unhealthy, ADULT
Health Status: unhealthy
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/17581601/
Other AEs: headache...
Other AEs:
headache (2.9%)
Sources:
https://pubmed.ncbi.nlm.nih.gov/17581601/
10 mg 1 times / day steady-state, oral
Studied dose
Dose: 10 mg, 1 times / day
Route: oral
Route: steady-state
Dose: 10 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/17581601/
unhealthy, ADULT
Health Status: unhealthy
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/17581601/
Disc. AE: flushing, headache...
Other AEs: headache...
AEs leading to
discontinuation/dose reduction:
flushing (2 patients)
headache (1 pt)
fatigue (1 pt)
vertigo (1 pt)
Other AEs:
headache (4.2%)
Sources:
https://pubmed.ncbi.nlm.nih.gov/17581601/
AEs

AEs

AESignificanceDosePopulation
bradycardia 1 pt
Disc. AE
560 mg single, oral
Overdose
Dose: 560 mg
Route: oral
Route: single
Dose: 560 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/21251326/
healthy, ADULT
Health Status: healthy
Age Group: ADULT
Sex: M
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/21251326/
hypotension 1 pt
Disc. AE
560 mg single, oral
Overdose
Dose: 560 mg
Route: oral
Route: single
Dose: 560 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/21251326/
healthy, ADULT
Health Status: healthy
Age Group: ADULT
Sex: M
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/21251326/
seizure 1 pt
Disc. AE
560 mg single, oral
Overdose
Dose: 560 mg
Route: oral
Route: single
Dose: 560 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/21251326/
healthy, ADULT
Health Status: healthy
Age Group: ADULT
Sex: M
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/21251326/
abdominal distension 1 pt
10 mg 1 times / day steady-state, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady-state
Dose: 10 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/28485829/
unhealthy, ADULT
Health Status: unhealthy
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/28485829/
dyspepsia 1 pt
10 mg 1 times / day steady-state, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady-state
Dose: 10 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/28485829/
unhealthy, ADULT
Health Status: unhealthy
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/28485829/
nausea 1 pt
10 mg 1 times / day steady-state, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady-state
Dose: 10 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/28485829/
unhealthy, ADULT
Health Status: unhealthy
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/28485829/
headache 2.9%
10 mg 1 times / day steady-state, oral
Studied dose
Dose: 10 mg, 1 times / day
Route: oral
Route: steady-state
Dose: 10 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/17581601/
unhealthy, ADULT
Health Status: unhealthy
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/17581601/
fatigue 1 pt
Disc. AE
10 mg 1 times / day steady-state, oral
Studied dose
Dose: 10 mg, 1 times / day
Route: oral
Route: steady-state
Dose: 10 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/17581601/
unhealthy, ADULT
Health Status: unhealthy
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/17581601/
headache 1 pt
Disc. AE
10 mg 1 times / day steady-state, oral
Studied dose
Dose: 10 mg, 1 times / day
Route: oral
Route: steady-state
Dose: 10 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/17581601/
unhealthy, ADULT
Health Status: unhealthy
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/17581601/
vertigo 1 pt
Disc. AE
10 mg 1 times / day steady-state, oral
Studied dose
Dose: 10 mg, 1 times / day
Route: oral
Route: steady-state
Dose: 10 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/17581601/
unhealthy, ADULT
Health Status: unhealthy
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/17581601/
flushing 2 patients
Disc. AE
10 mg 1 times / day steady-state, oral
Studied dose
Dose: 10 mg, 1 times / day
Route: oral
Route: steady-state
Dose: 10 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/17581601/
unhealthy, ADULT
Health Status: unhealthy
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/17581601/
headache 4.2%
10 mg 1 times / day steady-state, oral
Studied dose
Dose: 10 mg, 1 times / day
Route: oral
Route: steady-state
Dose: 10 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/17581601/
unhealthy, ADULT
Health Status: unhealthy
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/17581601/
PubMed

PubMed

TitleDatePubMed
Lercanidipine: a review of its use in hypertension.
2000 Nov
Increased vascular selectivity and prolonged pharmacological efficacy of the L-type Ca2+ channel antagonist lercanidipine in human cardiovascular tissue.
2005 Sep
Patents

Patents

20020068740
18
20020137755
7
EP0153016A2
3
JP2007512338A
11
JP2007512339A
43

Sample Use Guides

In Vivo Use Guide
The recommended dosage is 10 mg orally once a day at least 15 minutes before meals; the dose may be increased to 20 mg depending on the individual patient's response. In preclinical models lercanidipine is administered intraperitoneally.
Route of Administration: Other
In Vitro Use Guide
Lercanidipine demonstrated vasodilation effect in isolated vessel ring obtained from human arteria mammaria preparation (EC50 approx. 1 nM). Isolated vessel rings were precontracted by 0.3 mol/L prostaglandin F2.
Name Type Language
CARDIOVASC
Preferred Name English
LERCANIDIPINE HYDROCHLORIDE
JAN   MART.   MI   USAN   WHO-DD  
USAN  
Official Name English
Lercanidipine hydrochloride [WHO-DD]
Common Name English
LERCANIDIPINE HYDROCHLORIDE [JAN]
Common Name English
2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl methyl (4RS)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate monohydrochloride
Systematic Name English
LERCANIDIPINE HYDROCHLORIDE [MART.]
Common Name English
LERCANIDIPINE HYDROCHLORIDE [MI]
Common Name English
REC-15/2375
Code English
3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-, 2-((3,3-DIPHENYLPROPYL)METHYLAMINO)-1,1-DIMETHYLETHYL METHYL ESTER, MONOHYDROCHLORIDE
Common Name English
LERCANIDIPINE HCL
Common Name English
LERCANIDIPINE HYDROCHLORIDE [USAN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C333
Created by admin on Mon Mar 31 18:32:44 GMT 2025 , Edited by admin on Mon Mar 31 18:32:44 GMT 2025
Code System Code Type Description
MERCK INDEX
m6770
Created by admin on Mon Mar 31 18:32:44 GMT 2025 , Edited by admin on Mon Mar 31 18:32:44 GMT 2025
PRIMARY Merck Index
FDA UNII
OA8TFX68PE
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PRIMARY
NCI_THESAURUS
C87685
Created by admin on Mon Mar 31 18:32:44 GMT 2025 , Edited by admin on Mon Mar 31 18:32:44 GMT 2025
PRIMARY
MESH
C060343
Created by admin on Mon Mar 31 18:32:44 GMT 2025 , Edited by admin on Mon Mar 31 18:32:44 GMT 2025
PRIMARY
ChEMBL
CHEMBL250270
Created by admin on Mon Mar 31 18:32:44 GMT 2025 , Edited by admin on Mon Mar 31 18:32:44 GMT 2025
PRIMARY
EPA CompTox
DTXSID3046665
Created by admin on Mon Mar 31 18:32:44 GMT 2025 , Edited by admin on Mon Mar 31 18:32:44 GMT 2025
PRIMARY
USAN
OO-76
Created by admin on Mon Mar 31 18:32:44 GMT 2025 , Edited by admin on Mon Mar 31 18:32:44 GMT 2025
PRIMARY
SMS_ID
100000091632
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PRIMARY
CAS
132866-11-6
Created by admin on Mon Mar 31 18:32:44 GMT 2025 , Edited by admin on Mon Mar 31 18:32:44 GMT 2025
PRIMARY
EVMPD
SUB02894MIG
Created by admin on Mon Mar 31 18:32:44 GMT 2025 , Edited by admin on Mon Mar 31 18:32:44 GMT 2025
PRIMARY
PUBCHEM
157917
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PRIMARY
CAS
100427-27-8
Created by admin on Mon Mar 31 18:32:44 GMT 2025 , Edited by admin on Mon Mar 31 18:32:44 GMT 2025
NON-SPECIFIC STOICHIOMETRY
RXCUI
153679
Created by admin on Mon Mar 31 18:32:44 GMT 2025 , Edited by admin on Mon Mar 31 18:32:44 GMT 2025
PRIMARY RxNorm
ACTIVE MOIETY
Structure of LERCANIDIPINE
NIH
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