LERCANIDIPINE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C36H41N3O6.ClH
Molecular Weight	648.188
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of LERCANIDIPINE HYDROCHLORIDE

Structure Search

SMILES

Cl.COC(=O)C1=C(C)NC(C)=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC(C)(C)CN(C)CCC(C3=CC=CC=C3)C4=CC=CC=C4

InChI

InChIKey=WMFYOYKPJLRMJI-UHFFFAOYSA-N

InChI=1S/C36H41N3O6.ClH/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27;/h7-19,22,30,33,37H,20-21,23H2,1-6H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C36H41N3O6
Molecular Weight	611.7272
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://www.mhra.gov.uk/home/groups/par/documents/websiteresources/con071101.pdf
Curator's Comment: description was created based on several sources, including https://www.drugs.com/history/lercanidipine.html | https://www.ncbi.nlm.nih.gov/pubmed/27794423

Lercanidipine is antihypertensive drugs which acts by blocking L-type calcium channels, allowing relaxation and opening of blood vessels. Lercanidipine exists as a racemate, with anti-hypertensive activity residing primarily in S-enantiomer. NDA for lercanidipine was submitted to FDA in 2002 by Forest Laboratories, but FDA refused to approve the drug, and lercanidipine is not marketed in USA. Lercanidipine is also investigated in preclinical models of epilepsy and ischemic stroke.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Voltage-gated L-type calcium channel 92 Target ID: CHEMBL2095229 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16173926	Blocker 537		2.2 nM [Ki]

Conditions

Condition	Modality	Highest Phase	Product
Essential hypertension 17 Sources: http://www.mhra.gov.uk/home/groups/par/documents/websiteresources/con071101.pdf	Primary	Approved 8429	ZANIDIP Approved Use Lercanidipine is indicated for the treatment of mild to moderate essential hypertension
Epilepsy 121 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26673531	Primary	Preclinical	Unknown Approved Use Unknown
Stroke 144 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27794423	Palliative	Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Lercanidipine: a review of its use in hypertension.	2000 Nov	11129125
Nephroprotective effect of treatment with calcium channel blockers in spontaneously hypertensive rats.	2000 Sep	10945845
Tolerability of long-term treatment with lercanidipine versus amlodipine and lacidipine in elderly hypertensives.	2002 Nov	12441211
Lercanidipine in the treatment of hypertension.	2007 Mar	17341540
Neuroprotective Effect of Lercanidipine- A Novel Calcium Channel Blocker in Albino Mice.	2015 Nov	26673531

Patents

Sample Use Guides

In Vivo Use Guide

The recommended dosage is 10 mg orally once a day at least 15 minutes before meals; the dose may be increased to 20 mg depending on the individual patient's response. In preclinical models lercanidipine is administered intraperitoneally.

Route of Administration: Other

In Vitro Use Guide

Lercanidipine demonstrated vasodilation effect in isolated vessel ring obtained from human arteria mammaria preparation (EC50 approx. 1 nM). Isolated vessel rings were precontracted by 0.3 mol/L prostaglandin F2.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:37:03 GMT 2023` Edited by `admin` on `Fri Dec 15 16:37:03 GMT 2023`
Record UNII	OA8TFX68PE
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LERCANIDIPINE HYDROCHLORIDE

Official Name

English

Lercanidipine hydrochloride [WHO-DD]

Common Name

English

LERCANIDIPINE HYDROCHLORIDE [JAN]

Common Name

English

2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl methyl (4RS)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate monohydrochloride

Systematic Name

English

LERCANIDIPINE HYDROCHLORIDE [MART.]

Common Name

English

LERCANIDIPINE HYDROCHLORIDE [MI]

Common Name

English

REC-15/2375

Code

English

3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-, 2-((3,3-DIPHENYLPROPYL)METHYLAMINO)-1,1-DIMETHYLETHYL METHYL ESTER, MONOHYDROCHLORIDE

Common Name

English

LERCANIDIPINE HCL

Common Name

English

LERCANIDIPINE HYDROCHLORIDE [USAN]

Common Name

English

CARDIOVASC

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C333