Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C18H25F3N4O.C4H4O4 |
| Molecular Weight | 486.4847 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)\C=C\C(O)=O.FC(F)(F)C1=CC(=NC=C1)N2CCN(CCCCN3CCCC3=O)CC2
InChI
InChIKey=KILJTUTVUORPFQ-WLHGVMLRSA-N
InChI=1S/C18H25F3N4O.C4H4O4/c19-18(20,21)15-5-6-22-16(14-15)24-12-10-23(11-13-24)7-1-2-8-25-9-3-4-17(25)26;5-3(6)1-2-4(7)8/h5-6,14H,1-4,7-13H2;1-2H,(H,5,6)(H,7,8)/b;2-1+
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Prenatal exposure to cocaine: effects on aggression in Sprague-Dawley rats. | 1994 May |
|
| 5-HT1A receptor-mediated regulation of mitogen-activated protein kinase phosphorylation in rat brain. | 2002 Oct 4 |
|
| A review of the efficacy and tolerability of immediate-release and extended-release formulations of gepirone. | 2003 Jun |
|
| Gepirone extended-release: new evidence for efficacy in the treatment of major depressive disorder. | 2003 Mar |
|
| Human cytochromes mediating gepirone biotransformation at low substrate concentrations. | 2003 Mar |
|
| Pharmacokinetic evaluation of gepirone immediate-release capsules and gepirone extended-release tablets in healthy volunteers. | 2003 Sep |
|
| The design and preparation of metabolically protected new arylpiperazine 5-HT1A ligands. | 2004 Apr 5 |
|
| Relapse prevention with gepirone ER in outpatients with major depression. | 2005 Feb |
|
| Novel, flexible, and conformationally defined analogs of gepirone: synthesis and 5-HT1A, 5-HT2A, and D2 receptor activity. | 2005 Feb 15 |
|
| Early response and 8-week treatment outcome in GAD. | 2006 |
|
| Differential response to gepirone but not to chlordiazepoxide in malnourished rats subjected to learned helplessness. | 2008 Jan |
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142494-13-1
Created by
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70682615
Created by
admin on Sat Dec 16 10:17:33 GMT 2023 , Edited by admin on Sat Dec 16 10:17:33 GMT 2023
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O6W064NQ9M
Created by
admin on Sat Dec 16 10:17:33 GMT 2023 , Edited by admin on Sat Dec 16 10:17:33 GMT 2023
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ACTIVE MOIETY
SUBSTANCE RECORD
