Details
Stereochemistry | ACHIRAL |
Molecular Formula | 4Na.O7P2 |
Molecular Weight | 265.9024 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O
InChI
InChIKey=FQENQNTWSFEDLI-UHFFFAOYSA-J
InChI=1S/4Na.H4O7P2/c;;;;1-8(2,3)7-9(4,5)6/h;;;;(H2,1,2,3)(H2,4,5,6)/q4*+1;/p-4
DescriptionSources: https://books.google.ru/books?id=cPjjBwAAQBAJ&printsec=frontcover&hl=ru#v=onepage&q&f=falseCurator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11401820 | https://www.ncbi.nlm.nih.gov/pubmed/27061894 | http://www.food-info.net/uk/e/e450.htm
Sources: https://books.google.ru/books?id=cPjjBwAAQBAJ&printsec=frontcover&hl=ru#v=onepage&q&f=false
Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11401820 | https://www.ncbi.nlm.nih.gov/pubmed/27061894 | http://www.food-info.net/uk/e/e450.htm
Inorganic pyrophosphate (PPi ) has long been known as a by-product of many intracellular biosynthetic reactions. PPi plays the regulatory role in living systems, such as activities of enzymes, fidelity of syntheses of macromolecules, and proliferation of cells. PPi is used as a biochemical energy source instead of ATP especially in bacteria, protists, and plants. PPi may also regulate the formation and dissolution of bone as well as pathologic calcification of soft tissues and the formation of urinary stones. The formation of calcium pyrophosphate dihydrate crystals in the extracellular fluids of joints cause the disease called pseudogout. Sodium, potassium and calcium pyrophosphates (E450) are used as food additives as buffers and emulsifiers.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: GO:0030282 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27061894 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Diagnostic | Stannous Pyrophosphate Approved Usehttps://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=30046b6b-09ea-46b1-8e60-61c53e1e7282 |
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Diagnostic | Stannous Pyrophosphate Approved Usehttps://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=30046b6b-09ea-46b1-8e60-61c53e1e7282 |
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Diagnostic | Stannous Pyrophosphate Approved Usehttps://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=30046b6b-09ea-46b1-8e60-61c53e1e7282 |
PubMed
Title | Date | PubMed |
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Identification of the amino acid in the human immunodeficiency virus type 1 reverse transcriptase involved in the pyrophosphate binding of antiviral nucleoside triphosphate analogs and phosphonoformate. Implications for multiple drug resistance. | 1993 Dec 14 |
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Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. | 2008 Apr 10 |
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Hepatitis C virus helicase/NTPase: an efficient expression system and new inhibitors. | 2008 Jun |
Sample Use Guides
In Vivo Use Guide
Sources: http://www.food-info.net/uk/e/e450.htm
Acceptable Daily Intake: Up to 70 mg/kg bodyweight for all pyrophosphate containing food additives
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6155110
pyrophosphoric acid at the concentration of 0.1 - 1.0 mM does not affect spore germination of Streptomyces galilaeus ATCC 31133.
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Classification Tree | Code System | Code | ||
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DSLD |
2418 (Number of products:6)
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EPA PESTICIDE CODE |
76405
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CFR |
21 CFR 175.210
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DBSALT001492
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231-767-1
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DTXSID9042465
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1364532
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PRIMARY | RxNorm | ||
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4630
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854
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SUB04489MIG
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24403
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C77500
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C45678
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CONCEPT | Industrial Aid | ||
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7722-88-5
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56751
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C003319
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CHEMBL1160571
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O352864B8Z
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m10658
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71240
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TETRASODIUM PYROPHOSPHATE
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O352864B8Z
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ACTIVE MOIETY
SUBSTANCE RECORD