MELETIMIDE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C24H28N2O2
Molecular Weight	376.4913
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MELETIMIDE

Structure Search

SMILES

CC1=CC=C(CN2CCC(CC2)C3(CCC(=O)NC3=O)C4=CC=CC=C4)C=C1

InChI

InChIKey=YFBSRLFXFGHCCG-UHFFFAOYSA-N

InChI=1S/C24H28N2O2/c1-18-7-9-19(10-8-18)17-26-15-12-21(13-16-26)24(20-5-3-2-4-6-20)14-11-22(27)25-23(24)28/h2-10,21H,11-17H2,1H3,(H,25,27,28)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6055523 | https://link.springer.com/book/10.1007/978-1-4757-2085-3#about | https://patents.google.com/patent/US3125578A/en

Meletimide (R 5183) is a powerful anticholinergic agent with pronounced peripheral and central action.

CNS Activity

Originator

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
acetylcholine receptor activity 5 Target ID: GO:0015464 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6055523 \| https://patents.google.com/patent/US3125578A/en	Inhibitor 8504

PubMed

PubMed

Title	Date	PubMed
The peripheral and central anticholinergic properties of benzetimide (R 4929) and other atropine-like drugs as measured in a new anti-pilocarpine test in rats.	1967-08-04	6055523

Patents

Patents

Name

Type

Language

(±)-2-(1-(P-METHYLBENZYL)-4-PIPERIDYL)-2-PHENYLGLUTARIMIDE

Preferred Name

English

MELETIMIDE

Official Name

English

(3,4'-BIPIPERIDINE)-2,6-DIONE, 1'-((4-METHYLPHENYL)METHYL)-3-PHENYL-

Systematic Name

English

meletimide [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66880

Created by admin on Wed Apr 02 08:50:57 GMT 2025 , Edited by admin on Wed Apr 02 08:50:57 GMT 2025

Code System Code Type Description

EVMPD

SUB08723MIG

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ChEMBL

CHEMBL523900

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NCI_THESAURUS

C66080

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PUBCHEM

15560447

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SMS_ID

100000081447

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CAS

14745-50-7

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FDA UNII

NZP1W4BK07

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EPA CompTox

DTXSID60864529

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INN

1611

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ACTIVE MOIETY


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