Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C10H12ClNO2 |
Molecular Weight | 213.661 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NC[C@H](CC(O)=O)C1=CC=C(Cl)C=C1
InChI
InChIKey=KPYSYYIEGFHWSV-QMMMGPOBSA-N
InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)/t8-/m0/s1
Arbaclofen (STX209, R-baclofen), a selective agonist of GABA-B receptors, has been investigated in clinical trials for the treatment of autism spectrum disorder ASD, phase II and for the treatment of patients with fragile X syndrome in phase III. As a result, the drug did not meet the primary outcome of improved social avoidance in FXS in either study. In spite of positive results in some children with ASD, further study will be needed to replicate and extend these initial findings. Arbaclofen has also been investigated in phase III clinical trials as a treatment for spasticity due to multiple sclerosis.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2111463 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22993295 |
PubMed
Title | Date | PubMed |
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Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. | 1997 Mar 20 |
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Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen. | 2012 Sep 19 |
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Clinical potential, safety, and tolerability of arbaclofen in the treatment of autism spectrum disorder. | 2014 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28616094
5 mg BID to 15 mg TID
Route of Administration:
Oral
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C29696
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FDA ORPHAN DRUG |
271808
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EU-Orphan Drug |
EU/3/11/858
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m2200
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DB08891
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XX-44
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DTXSID90219366
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69308-37-8
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CHEMBL301742
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9360
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100000177226
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44602
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NYU6UTW25B
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C90890
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ACTIVE MOIETY
PRODRUG (METABOLITE ACTIVE)
SALT/SOLVATE (PARENT)