ARBACLOFEN HYDROCHLORIDE

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H12ClNO2.ClH
Molecular Weight	250.122
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.NC[C@H](CC(O)=O)C1=CC=C(Cl)C=C1

InChI

InChIKey=WMNUVYYLMCMHLU-QRPNPIFTSA-N

InChI=1S/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	C10H12ClNO2
Molecular Weight	213.661
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27748740 | https://www.ncbi.nlm.nih.gov/pubmed/28616094 | https://clinicaltrials.gov/ct2/show/NCT01743651

Arbaclofen (STX209, R-baclofen), a selective agonist of GABA-B receptors, has been investigated in clinical trials for the treatment of autism spectrum disorder ASD, phase II and for the treatment of patients with fragile X syndrome in phase III. As a result, the drug did not meet the primary outcome of improved social avoidance in FXS in either study. In spite of positive results in some children with ASD, further study will be needed to replicate and extend these initial findings. Arbaclofen has also been investigated in phase III clinical trials as a treatment for spasticity due to multiple sclerosis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
GABA-B receptor 32 Target ID: CHEMBL2111463 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22993295	Agonist 2752

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

5 mg BID to 15 mg TID

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:18:46 GMT 2025` Edited by `admin` on `Mon Mar 31 18:18:46 GMT 2025`
Record UNII	8703929ITD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ARBACLOFEN HYDROCHLORIDE

Common Name

English

(R)-BACLOFEN HYDROCHLORIDE

Preferred Name

English

BACLOFEN HYDROCHLORIDE, R-

Common Name

English

BACLOFEN (R)-FORM HYDROCHLORIDE [MI]

Common Name

English

BACLOFEN HYDROCHLORIDE, R(-)-

Common Name

English

D-BACLOFEN HYDROCHLORIDE

Common Name

English

BENZENEPROPANOIC ACID, .BETA.-(AMINOMETHYL)-4-CHLORO-, HYDROCHLORIDE (1:1), (.BETA.R)-

Common Name

English

(R)-4-AMINO-3-(4-CHLOROPHENYL)BUTANOIC ACID HYDROCHLORIDE

Systematic Name

English

BACLOFEN HYDROCHLORIDE, (R)-

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29696