Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C18H21NO3.ClH.2H2O |
| Molecular Weight | 371.856 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.Cl.[H][C@@]12OC3=C4C(C[C@H]5N(C)CC[C@@]14[C@@]5([H])C=C[C@@H]2O)=CC=C3OC
InChI
InChIKey=AWFZELCPUGEQGQ-NLMNJOOOSA-N
InChI=1S/C18H21NO3.ClH.2H2O/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;;;/h3-6,11-13,17,20H,7-9H2,1-2H3;1H;2*1H2/t11-,12+,13-,17-,18-;;;/m0.../s1
Codeine is an opiate used to manage mild to moderate pain severe enough to require an opioid. Codeine is a selective agonist for the mu opioid receptor and has an affinity to delta and kappa-opioid receptors. In some countries, this drug is regulated under various narcotic control laws, because its chronic use can cause physical dependence. In others, it is available without a medical prescription in combination with paracetamol.
CNS Activity
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL233 |
6.1 µM [EC50] | ||
Target ID: P41145 Gene ID: 4986.0 Gene Symbol: OPRK1 Target Organism: Homo sapiens (Human) |
|||
Target ID: P41143 Gene ID: 4985.0 Gene Symbol: OPRD1 Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | CAPITAL AND CODEINE Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Analgesic abuse, ureteric obstruction, and retroperitoneal fibrosis. | 1975 Apr 12 |
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| Mimicking gene defects to treat drug dependence. | 2000 |
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| [Pharmacokinetic and toxicokinetic parameters of some drugs of abuse]. | 2001 |
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| [Guillain-Barre syndrome as a result of poisoning with a mixture of "kompot"(Polish heroin) and drugs]. | 2001 |
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| Determination of opiates in serum, saliva and hair addicted persons. | 2001 |
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| Results of a phase-I/II randomized, masked, placebo-controlled trial of recombinant human interleukin-11 (rhIL-11) in the treatment of subjects with active rheumatoid arthritis. | 2001 |
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| The use of compound 48/80 and codeine phosphate as positive controls for intradermal skin testing in dogs. | 2001 Apr |
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| Chromatographic analysis of phenethylamine-antihistamine combinations using C8, C18 or cyano columns and micellar sodium dodecyl sulfate-pentanol mixtures. | 2001 Apr |
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| Angle closure risk from proprietary medicines. | 2001 Apr |
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| [Adverse cutaneous side-effect of codeine administration]. | 2001 Apr 15 |
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| Simultaneous determination of codeine and ethyl morphine HCL in tablet formulations using LC. | 2001 Aug |
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| Prescribing limitations. | 2001 Aug 11 |
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| [Paracetamol-codeine induced hepatic colic]. | 2001 Aug-Sep |
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| Opioids for chronic nonmalignant pain. Attitudes and practices of primary care physicians in the UCSF/Stanford Collaborative Research Network. University of California, San Francisco. | 2001 Feb |
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| The safety of dextromethorphan in pregnancy : results of a controlled study. | 2001 Feb |
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| Detection of acetylcodeine in urine as an indicator of illicit heroin use: method validation and results of a pilot study. | 2001 Feb |
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| Successful use of propranolol in migraine associated with electroconvulsive therapy. | 2001 Jan |
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| Packaging of codeine phosphate suppositories. | 2001 Jan |
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| Using evidence from different sources: an example using paracetamol 1000 mg plus codeine 60 mg. | 2001 Jan 10 |
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| Opiate-sensitivity: clinical characteristics and the role of skin prick testing. | 2001 Jul |
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| Contribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: a PK-PD modelling analysis. | 2001 Jul |
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| Head-column field-amplified sample stacking in presence of siphoning. Application to capillary electrophoresis-electrospray ionization mass spectrometry of opioids in urine. | 2001 Jul 27 |
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| [Chronic pain in geriatrics]. | 2001 Jun |
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| Oral ibuprofen versus paracetamol plus codeine for analgesia after ambulatory surgery. | 2001 Jun |
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| Ulcerated hemangiomas: clinical characteristics and response to therapy. | 2001 Jun |
|
| Codeine phosphate in paediatric medicine. | 2001 Mar |
|
| GC-MS determination of heroin metabolites in meconium: evaluation of four solid-phase extraction cartridges. | 2001 Mar |
|
| Quantitation of morphine and codeine in human urine using high-filed asymmetric waveform ion mobility spectrometry (FAIMS) with mass spectrometric detection. | 2001 Mar |
|
| Acetylcodeine as a marker of illicit heroin in human hair: method validation and results of a pilot study. | 2001 Mar |
|
| Effect of an enteric-release formulation of naloxone on intestinal transit in volunteers taking codeine. | 2001 May |
|
| The analgesic effect of codeine as compared to imipramine in different human experimental pain models. | 2001 May |
|
| [Analgesics-induced chronic renal failure in patients on dialysis therapy in Hungary]. | 2001 May 13 |
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| Tramadol/acetaminophen combination tablets and codeine/acetaminophen combination capsules for the management of chronic pain: a comparative trial. | 2001 Sep |
|
| Pain control in medical abortion. | 2001 Sep |
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| Classification Tree | Code System | Code | ||
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DEA NO. |
9050
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NTZ53GG7XN
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DBSALT001068
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Codeine hydrochloride
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DTXSID10207886
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SUB01405MIG
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1115966
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44146477
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SUB11840MIG
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5916-29-0
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100000076636
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ACTIVE MOIETY
SUBSTANCE RECORD
