Details
Stereochemistry | ACHIRAL |
Molecular Formula | C19H18ClN5.CH4O3S |
Molecular Weight | 447.938 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CS(O)(=O)=O.CN(C)CC1=NN=C2CN=C(C3=CC=CC=C3)C4=C(C=CC(Cl)=C4)N12
InChI
InChIKey=FENBITQPWFCMEB-UHFFFAOYSA-N
InChI=1S/C19H18ClN5.CH4O3S/c1-24(2)12-18-23-22-17-11-21-19(13-6-4-3-5-7-13)15-10-14(20)8-9-16(15)25(17)18;1-5(2,3)4/h3-10H,11-12H2,1-2H3;1H3,(H,2,3,4)
Adinazolam, a benzodiazepine agonist, is an effective anxiolytic agent with antidepressant properties. It was shown, that adinazolam by itself had relatively weak benzodiazepine agonist activity, and much of the pharmacological activity belonged to its active metabolite N-desmethyladinazolam (NDMAD). Adinazolam has never been FDA approved, but it is sold as a research chemical.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2109243 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6148400 |
PubMed
Title | Date | PubMed |
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Regulation of serotonin type 2 (5-HT2) and beta-adrenergic receptors in rat cerebral cortex following novel and classical antidepressant treatment. | 1991 Nov |
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Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man. | 1998 Mar |
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A follow-up study of DSM-III-R generalized anxiety disorder with syndromal and subsyndromal major depression. | 2003 Feb |
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The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. | 2003 Feb 28 |
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Evaluation of a basic physiologically based pharmacokinetic model for simulating the first-time-in-animal study. | 2007 Jul |
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Prediction of modified release pharmacokinetics and pharmacodynamics from in vitro, immediate release, and intravenous data. | 2009 Jun |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3298327
from 90 to 40 mg/day.
Route of Administration:
Oral
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NCI_THESAURUS |
C1012
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42611
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CHEMBL328250
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C074080
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DBSALT002297
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C76532
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57938-82-6
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NT8S62A727
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W-62
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m1418
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DTXSID00206641
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ACTIVE MOIETY
SUBSTANCE RECORD