ADINAZOLAM MESYLATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H18ClN5.CH4O3S
Molecular Weight	447.938
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CS(O)(=O)=O.CN(C)CC1=NN=C2CN=C(C3=CC=CC=C3)C4=C(C=CC(Cl)=C4)N12

InChI

InChIKey=FENBITQPWFCMEB-UHFFFAOYSA-N

InChI=1S/C19H18ClN5.CH4O3S/c1-24(2)12-18-23-22-17-11-21-19(13-6-4-3-5-7-13)15-10-14(20)8-9-16(15)25(17)18;1-5(2,3)4/h3-10H,11-12H2,1-2H3;1H3,(H,2,3,4)

HIDE SMILES / InChI

Molecular Formula	C19H18ClN5
Molecular Weight	351.833
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	CH4O3S
Molecular Weight	96.106
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6320036 | https://www.ncbi.nlm.nih.gov/pubmed/3298327 | https://www.ncbi.nlm.nih.gov/pubmed/9600717 | https://www.ncbi.nlm.nih.gov/pubmed/27535017

Adinazolam, a benzodiazepine agonist, is an effective anxiolytic agent with antidepressant properties. It was shown, that adinazolam by itself had relatively weak benzodiazepine agonist activity, and much of the pharmacological activity belonged to its active metabolite N-desmethyladinazolam (NDMAD). Adinazolam has never been FDA approved, but it is sold as a research chemical.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
GABA-A receptor; benzodiazepine site 38 Target ID: CHEMBL2109243 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6148400	Agonist 2678

PubMed

Title	Date	PubMed
The early acquisition of two-way (shuttle-box) avoidance as an anxiety-mediated behavior: psychopharmacological validation.	1991 Jan	1673080
Regulation of serotonin type 2 (5-HT2) and beta-adrenergic receptors in rat cerebral cortex following novel and classical antidepressant treatment.	1991 Nov	1664741
The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review.	2003 Feb 28	12600700
The effect of sympathetic antagonists on the antidepressant action of alprazolam.	2008 Jun 1	21499463
Recent trends in the impurity profile of pharmaceuticals.	2010 Jul	22247862

Patents

Sample Use Guides

In Vivo Use Guide

from 90 to 40 mg/day.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:20:24 UTC 2023` Edited by `admin` on `Fri Dec 15 15:20:24 UTC 2023`
Record UNII	NT8S62A727
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ADINAZOLAM MESYLATE

Official Name

English

ADINAZOLAM MESYLATE [USAN]

Common Name

English

4H-(1,2,4)TRIAZOLO(4,3-A)(1,4)BENZODIAZEPINE-1-METHANAMINE, 8-CHLORO-N,N-DIMETHYL-6-PHENYL-, MONOMETHANESULFONATE

Systematic Name

English

4H-(1,2,4)TRIAZOLO(4,3-A)(1,4)BENZODIAZEPINE-1-METHANAMINE, 8-CHLORO-N,N-DIMETHYL-6-PHENYL-, MONOMETHANESULPHONATE

Systematic Name

English

ADINAZOLAM METHANESULFONATE [MI]

Common Name

English

ADINAZOLAM METHANESULFONATE

Common Name

English

8-Chloro-1-[(dimethylamino)methyl]-6-phenyl-4H-S-triazolo[4,3-a][1,4]benzodiazepine monomethanesulfonate

Systematic Name

English

U-41,123F

Code

English

ADINAZOLAM MESILATE [MART.]

Common Name

English

ADINAZOLAM MESILATE

Common Name

English

U-41123F

Code

English

8-CHLORO-1-((DIMETHYLAMINO)METHYL)-6-PHENYL-4H-S-TRIAZOLO(4,3-A)(1,4)BENZODIAZEPINE MONOMETHANESULPHONATE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1012