ISOGANCICLOVIR

Details

Stereochemistry	RACEMIC
Molecular Formula	C9H13N5O4
Molecular Weight	255.2306
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=NC2=C(N=CN2COCC(O)CO)C(=O)N1

InChI

InChIKey=YMJRISBBXAOKCD-UHFFFAOYSA-N

InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-2-5(16)1-15/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)

HIDE SMILES / InChI

Approval Year

PubMed

Title	Date	PubMed
Synthesis and antiherpetic activity of (S)-, (R)-, and (+/-)-9-[(2,3-dihydroxy-1-propoxy)methyl]guanine, linear isomers of 2'-nor-2'-deoxyguanosine.	1985 Jul	2989523
The ophthalmological features of AIDS and AIDS related disorders.	1986	3026068
Synthesis and anti-herpes-virus activity of acyclic 2'-deoxyguanosine analogues related to 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine.	1986 Aug	3016263
Successful treatment of murine cytomegalovirus disease does not prevent latent virus infection.	1986 Aug	3016127
Life-threatening cytomegalovirus infection treated with dihydropropoxymethylguanine.	1986 Mar 22	2869359
Treatment of serious cytomegalovirus infections with 9-(1,3-dihydroxy-2-propoxymethyl)guanine in patients with AIDS and other immunodeficiencies.	1986 Mar 27	3005861
Enzymatic phosphorylation of the antiherpetic agent 9-[(2,3-dihydroxy-1-propoxy)methyl]guanine.	1986 May	3009816
Synthesis and antiherpes virus activity of phosphate and phosphonate derivatives of 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine.	1986 May	3009811
Respiratory pharmacology. Antiviral agents.	1986 Sep	2429801
Selection of a derivative of the antiviral agent 9-[(1,3-dihydroxy-2-propoxy)-methyl]guanine (DHPG) with improved oral absorption.	1987 Apr	3334410
Synthesis of cytomegalovirus DNA is an antiviral target late in virus growth.	1987 Jun	3035060
Fine structure of cells infected with human cytomegalovirus after treatment with 9-(1,3-dihydroxy-2-propoxymethyl)guanine.	1987 Jun	3035059
Successful treatment of cytomegalovirus disease with 9-(1,3-dihydroxy-2-propoxymethyl guanine).	1988 Feb	2831645
Treatment of cytomegalovirus infections in renal transplant recipients with 9-(1,3-dihydroxy-2-propoxymethyl) guanine.	1988 Jun	2837848
Responses of neurologic complications of AIDS to 3'-azido-3'-deoxythymidine and 9-(1,3-dihydroxy-2-propoxymethyl) guanine. I. Clinical features.	1988 Mar-Apr	3163817

Patents

Name

Type

Language

ISOGANCICLOVIR

Common Name

English

(±)-2-AMINO-9-((2,3-DIHYDROXYPROPOXY)METHYL)-1,9-DIHYDRO-6H-PURIN-6-ONE

Systematic Name

English

GANCICLOVIR IMPURITY E [EP IMPURITY]

Common Name

English

GANCICLOVIR RELATED COMPOUND A [USP-RS]

Common Name

English

6H-PURIN-6-ONE, 2-AMINO-9-((2,3-DIHYDROXYPROPOXY)METHYL)-1,9-DIHYDRO-

Systematic Name

English

GANCICLOVIR RELATED COMPOUND A

Common Name

English

(RS)-2-AMINO-9-(2,3-DIHYDROXY-PROPOXYMETHYL)-1,9-DIHYDRO-PURIN-6-ONE

Systematic Name

English

2-AMINO-9-((2,3-DIHYDROXYPROPOXY)METHYL)-1,9-DIHYDRO-6H-PURIN-6-ONE

Systematic Name

English

GANCICLOVIR RELATED COMPOUND A [USP IMPURITY]

Common Name

English

2-AMINO-9-(((2RS)-2,3-DIHYDROXYPROPOXY)METHYL)-1,9-DIHYDRO-6H-PURIN-6-ONE

Systematic Name

English

3-((2-AMINO-6-HYDROXY-9H-PURIN-9-YL)METHOXY)-1,2-PROPANEDIOL

Systematic Name

English

Code System Code Type Description

RS_ITEM_NUM

1288317

Created by admin on Sat Dec 16 04:40:39 GMT 2023 , Edited by admin on Sat Dec 16 04:40:39 GMT 2023

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FDA UNII

NNJ00018WY

Created by admin on Sat Dec 16 04:40:39 GMT 2023 , Edited by admin on Sat Dec 16 04:40:39 GMT 2023

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CAS

86357-09-7

Created by admin on Sat Dec 16 04:40:39 GMT 2023 , Edited by admin on Sat Dec 16 04:40:39 GMT 2023

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PUBCHEM

135446919

Created by admin on Sat Dec 16 04:40:39 GMT 2023 , Edited by admin on Sat Dec 16 04:40:39 GMT 2023

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SUBSTANCE RECORD


					NNJ00018WY

ISOGANCICLOVIR