FLUMEZAPINE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H19FN4S
Molecular Weight	330.423
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CN1CCN(CC1)C2=NC3=C(NC4=C2C=C(C)S4)C=CC(F)=C3

InChI

InChIKey=JBHUBOISLBWHAR-UHFFFAOYSA-N

InChI=1S/C17H19FN4S/c1-11-9-13-16(22-7-5-21(2)6-8-22)19-15-10-12(18)3-4-14(15)20-17(13)23-11/h3-4,9-10,20H,5-8H2,1-2H3

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Description

FLUMEZAPINE, a benzodiazepine derivative, is an antipsychotic agent. It is a potent blocker of dopamine D2 and of some serotonin receptors. Its clinical development was dropped due to toxicology concerns.

Originator

Approval Year

PubMed

Show entries

Title	Date	PubMed
Central dopamine receptors mediating pergolide-induced elevation of serum corticosterone in rats. Characterization by the use of antagonists.	1984 Dec	6527743
Flumezapine and zotepine: 5-hydroxytryptamine antagonism not involved in the lack of synergism of these antipsychotic drugs with amfonelic acid in rats.	1985 Oct	2867152
Flumezapine, an antagonist of central dopamine and serotonin receptors.	1986 Oct	2879325

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Patents

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Name

Type

Language

LY-120363

Preferred Name

English

FLUMEZAPINE

Official Name

English

LY120363

Code

English

flumezapine [INN]

Common Name

English

7-Fluoro-2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine

Systematic Name

English

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Code System

Code

Type

Description

CAS

61325-80-2

PRIMARY

NCI_THESAURUS

C174753

PRIMARY

WIKIPEDIA

Flumezapine

PRIMARY

EPA CompTox

DTXSID60976813

PRIMARY

SMS_ID

100000080689

PRIMARY

Showing 1 to 5 of 11 entries

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ACTIVE MOIETY


					NA9GM10X6C

FLUMEZAPINE