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Details

Stereochemistry ACHIRAL
Molecular Formula C17H19FN4S
Molecular Weight 330.423
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLUMEZAPINE

SMILES

CN1CCN(CC1)C2=NC3=C(NC4=C2C=C(C)S4)C=CC(F)=C3

InChI

InChIKey=JBHUBOISLBWHAR-UHFFFAOYSA-N
InChI=1S/C17H19FN4S/c1-11-9-13-16(22-7-5-21(2)6-8-22)19-15-10-12(18)3-4-14(15)20-17(13)23-11/h3-4,9-10,20H,5-8H2,1-2H3

HIDE SMILES / InChI

Description

FLUMEZAPINE, a benzodiazepine derivative, is an antipsychotic agent. It is a potent blocker of dopamine D2 and of some serotonin receptors. Its clinical development was dropped due to toxicology concerns.

Originator

Approval Year

PubMed

PubMed

TitleDatePubMed
Central dopamine receptors mediating pergolide-induced elevation of serum corticosterone in rats. Characterization by the use of antagonists.
1984 Dec
Flumezapine and zotepine: 5-hydroxytryptamine antagonism not involved in the lack of synergism of these antipsychotic drugs with amfonelic acid in rats.
1985 Oct
Flumezapine, an antagonist of central dopamine and serotonin receptors.
1986 Oct
Patents
Name Type Language
FLUMEZAPINE
INN   USAN  
INN   USAN  
Official Name English
LY-120363
Code English
LY120363
Code English
FLUMEZAPINE [INN]
Common Name English
FLUMEZAPINE [USAN]
Common Name English
10H-THIENO(2,3-B)(1,5)BENZODIAZEPINE, 7-FLUORO-2-METHYL-4-(4-METHYL-1-PIPERAZINYL)-
Systematic Name English
Code System Code Type Description
CAS
61325-80-2
Created by admin on Tue Oct 22 19:50:25 UTC 2019 , Edited by admin on Tue Oct 22 19:50:25 UTC 2019
PRIMARY
MESH
C045983
Created by admin on Tue Oct 22 19:50:25 UTC 2019 , Edited by admin on Tue Oct 22 19:50:25 UTC 2019
PRIMARY
ChEMBL
CHEMBL273786
Created by admin on Tue Oct 22 19:50:25 UTC 2019 , Edited by admin on Tue Oct 22 19:50:25 UTC 2019
PRIMARY
INN
5123
Created by admin on Tue Oct 22 19:50:25 UTC 2019 , Edited by admin on Tue Oct 22 19:50:25 UTC 2019
PRIMARY
EVMPD
SUB07702MIG
Created by admin on Tue Oct 22 19:50:25 UTC 2019 , Edited by admin on Tue Oct 22 19:50:25 UTC 2019
PRIMARY