U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Parathyroid hormone (PTH) is an 84-amino acid peptide that regulates the function of osteoblasts and osteocytes and is secreted by the parathyroid gland in response to changes in the concentration of extracellular calcium. Parathyroid hormone is approved under the brand name NATPARA as an adjunct to calcium and vitamin D to control hypocalcemia in patients with hypoparathyroidism. It is also available for treatment of postmenopausal osteoporosis in many European countries. Parathyroid hormone is an activator of parathyroid hormone 2 receptor. In addition, was shown, that downregulation of Notch in osteoblasts and osteocytes may represent a mechanism contributing to the anabolic effects of parathyroid hormone in bone.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P49190
Gene ID: 5746.0
Gene Symbol: PTH2R
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
NATPARA

Approved Use

NATPARA is a parathyroid hormone indicated as an adjunct to calcium and vitamin D to control hypocalcemia in patients with hypoparathyroidism. Because of the potential risk of osteosarcoma, NATPARA is recommended only for patients who cannot be well-controlled on calcium supplements and active forms of vitamin D alone. NATPARA was not studied in patients with hypoparathyroidism caused by calcium-sensing receptor mutations. NATPARA was not studied in patients with acute post-surgical hypoparathyroidism.

Launch Date

1.42205754E12
Palliative
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Parathyroid hormone receptor internalization is independent of protein kinase A and phospholipase C activation.
2001 Sep
Mixed-treatment comparison of anabolic (teriparatide and PTH 1-84) therapies in women with severe osteoporosis.
2012 Mar
Current perspectives on parathyroid hormone (PTH) and PTH-related protein (PTHrP) as bone anabolic therapies.
2013 May 15
The effect of parathyroid hormone and teriparatide on fracture healing.
2015 Jan
Parathyroid Hormone-Related Protein Analogs as Osteoporosis Therapies.
2016 Apr
Patents

Sample Use Guides

Initiate NATPARA ((parathyroid hormone) 50 mcg once daily as a subcutaneous njection in the thigh (alternate thigh very day). n patients using active forms of vitamine D decrease the dose of active vitamin D by 50%, if serum calcium is above 7.5 mg/dL. In patients using calcium supplements, maintain calcium supplement dose. Measure serum calcium concentration within 3 to 7 days.
Route of Administration: Other
In Vitro Use Guide
Unknown
Name Type Language
PARATHYROID HORMONE
DASH   INN   MART.   MI   USAN   WHO-DD  
INN   USAN  
Official Name English
PARATHYROID HORMONE [INN]
Common Name English
PARATHYROID HORMONE [WHO-DD]
Common Name English
NATPAR
Brand Name English
PREOTACT
Brand Name English
PARATHYROID [HSDB]
Common Name English
ALX-1-11
Code English
NATPARA
Brand Name English
PTH
Common Name English
PARATHYROID HORMONE [PURPLE BOOK, CDER]
Common Name English
PARATHORMONUM [HPUS]
Common Name English
PARATHYROID HORMONE [USAN]
Common Name English
PARATHYROID HORMONE (RDNA)
EMA EPAR  
Common Name English
PARATHORMONE (HUMAN RECOMBINANT)
Common Name English
PARATHYROID HORMONE [MI]
Common Name English
PARATHYROID HORMONE (RDNA) [EMA EPAR]
Common Name English
PARATHORMONUM
HPUS  
Common Name English
PARATHYROID HORMONE [MART.]
Common Name English
Classification Tree Code System Code
EU-Orphan Drug EU/3/13/1210
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NDF-RT N0000180851
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NDF-RT N0000011221
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CFR 21 CFR 862.1545
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WHO-ATC H05AA03
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NDF-RT N0000011221
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EMA ASSESSMENT REPORTS PREOTACT (WITHDRAWN: OSTEOPOROSIS, POSTMENOPAUSAL)
Created by admin on Sat Jun 26 18:57:41 UTC 2021 , Edited by admin on Sat Jun 26 18:57:41 UTC 2021
WHO-VATC QH05AA03
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FDA ORPHAN DRUG 246707
Created by admin on Sat Jun 26 18:57:41 UTC 2021 , Edited by admin on Sat Jun 26 18:57:41 UTC 2021
Code System Code Type Description
EVMPD
SUB21634
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PRIMARY
ChEMBL
CHEMBL2108078
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PRIMARY
NCI_THESAURUS
C62555
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PRIMARY
DRUG BANK
DB05829
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PRIMARY
INN
8441
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PRIMARY
CAS
9002-64-6
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PRIMARY
RXCUI
1427222
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PRIMARY RxNorm
DRUG CENTRAL
4936
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PRIMARY
MERCK INDEX
M8408
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PRIMARY Merck Index
FDA UNII
N19A0T0E5J
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PRIMARY
EVMPD
SUB181442
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PRIMARY
IUPHAR
1785
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PRIMARY
MESH
D010281
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PRIMARY