ETIFENIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H22N2O5
Molecular Weight	322.3563
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC1=CC=CC(CC)=C1NC(=O)CN(CC(O)=O)CC(O)=O

InChI

InChIKey=WNIDXAKKFOKNEF-UHFFFAOYSA-N

InChI=1S/C16H22N2O5/c1-3-11-6-5-7-12(4-2)16(11)17-13(19)8-18(9-14(20)21)10-15(22)23/h5-7H,3-4,8-10H2,1-2H3,(H,17,19)(H,20,21)(H,22,23)

HIDE SMILES / InChI

Description
Sources: http://www.rotop-pharmaka.de/fileadmin/user_upload/GFIs/GFI-EHIDA-DE-eng-01.pdf
Curator's Comment: description was created based on several sources, including: http://eknygos.lsmuni.lt/springer/439/173-337.pdf

Etifenin is a diagnostic radiopharmaceutical for the liver function assessment. It is used for hepatobiliary function scintigraphy where there is the following suspicion: Acute cholecystitis; Chronic gall duct changes; Occlusion of ductus choledochus; Congenital aberrances of the gall duct system such as atresia; Provision of evidence of bile leak; For differential diagnosis of intrahepatic growth (suspicion of focal nodular hyperplasia versus suspicion of liver cell cancer). The diagnostic significance in liver cancer is rather marginal compared to other imaging procedures. No information on adverse reactions after intravenous injection of the ready-to-use solution is available.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hepatobiliary disease 8 Sources: http://www.rotop-pharmaka.de/fileadmin/user_upload/GFIs/GFI-EHIDA-DE-eng-01.pdf	Diagnostic		Approved 8583	ROTOP-EHIDA Approved Use [99mTc]EHIDA is used for hepatobiliary function scintigraphy.

PubMed

Title	Date	PubMed
Congenital Tracheobiliary Fistula Shown on 99mTc-EHIDA Hepatobiliary Scintigraphy.	2016-02	26447371
Monitoring Hepatocyte Dysfunction and Biliary Complication After Liver Transplantation Using Quantitative Hepatobiliary Scintigraphy.	2015-11	26559297
The role of cholescintigraphy in demonstrating delayed post prandial gallbladder motility in cirrhotic patients.	2015-03-18	26187211

Patents

Sample Use Guides

In Vivo Use Guide

Single injection after reconstitution with sodium [99mTc]per-technetate solution. Adults with a normal liver function will receive an activity of 150 MBq and up to 420 MBq if they have a disturbed liver function with serum bilirubin values >25 mol/l. Patients should not eat during at least 2 hours or better 4 hours prior to administration.

Route of Administration: Intravenous

In Vitro Use Guide

The HIDA/saline and HIDA/plasma mixtures were incubated at 37°C for 15 min, then a 0.5 ml aliquot of each mixture was applied to the top of its respective Sephadex column. Incubation in plasma had no effect on the chromatogram of Etifenin. Results indicate that, under the conditions described, Etifenin is not a protein(albumin)-bound agent.

Name

Type

Language

ETIFENIN [USAN]

Preferred Name

English

ETIFENIN

Official Name

English

GLYCINE, N-(CARBOXYMETHYL)-N-(2-((2,6-DIETHYLPHENYL)AMINO)-2-OXOETHYL)-

Systematic Name

English

etifenin [INN]

Common Name

English

[[[(2,6-Diethylphenyl)carbamoyl]methyl]imino]diacetic acid

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1937