PENTHIENATE BROMIDE

First approved in 1954

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H30NO3S.Br
Molecular Weight	420.405
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Br-].CC[N+](C)(CC)CCOC(=O)C(O)(C1CCCC1)C2=CC=CS2

InChI

InChIKey=VWGJUXTWIWCQGL-UHFFFAOYSA-M

InChI=1S/C18H30NO3S.BrH/c1-4-19(3,5-2)12-13-22-17(20)18(21,15-9-6-7-10-15)16-11-8-14-23-16;/h8,11,14-15,21H,4-7,9-10,12-13H2,1-3H3;1H/q+1;/p-1

HIDE SMILES / InChI

Description
Sources: https://www.drugfuture.com/chemdata/penthienate-bromide.html | https://www.ncbi.nlm.nih.gov/pubmed/13154614

PENTHIENATE, a synthetic anticholinergic, depresses the motility and secretion of the stomach and reduces the motor activity of the intestine by blocking vagal stimulation. It is used in the treatment of peptic ulcer and dyspepsia.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Spasms 4 Sources: http://www.drugfuture.com/chemdata/penthienate-bromide.html https://books.google.ru/books?id=_J2ti4EkYpkC&pg=PA2935-IA243&lpg=PA2935-IA243&dq=PENTHIENATE retrieved from Pharmaceutical Manufacturing Encyclopedia, 3rd Edition: William Andrew Publishing, p. 2935	Primary		Approved 8429	Monodral Approved Use Antispasmodic Launch Date 1954

Doses

Dose	Population	Adverse events
5 mg 3 times / day multiple, oral Dose: 5 mg, 3 times / day Route: oral Route: multiple Dose: 5 mg, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/8937366	unhealthy, 63.5 years (range: 36-85 years) n = 20 Health Status: unhealthy Age Group: 63.5 years (range: 36-85 years) Sex: M+F Population Size: 20 Sources: https://pubmed.ncbi.nlm.nih.gov/8937366	Disc. AE: Swallowing difficult... AEs leading to discontinuation/dose reduction: Swallowing difficult (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/8937366

AEs

AE	Significance	Dose	Population
Swallowing difficult	1 patient Disc. AE	5 mg 3 times / day multiple, oral Dose: 5 mg, 3 times / day Route: oral Route: multiple Dose: 5 mg, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/8937366	unhealthy, 63.5 years (range: 36-85 years) n = 20 Health Status: unhealthy Age Group: 63.5 years (range: 36-85 years) Sex: M+F Population Size: 20 Sources: https://pubmed.ncbi.nlm.nih.gov/8937366

Sourcing

Vendor/Aggregator	ID	URL
AAA Chemistry	AR-1I7286
ABI Chem	AC1L1LQC
ABI Chem	AC1Q65RI
Compound Cloud	6066
Compound Cloud	6067
NCI Plated 2007	61814
NovoSeek	6067
ZINC	ZINC000001690860	http://zinc15.docking.org/substances/ZINC000001690860
ZINC	ZINC000002041344	http://zinc15.docking.org/substances/ZINC000002041344
eMolecules	260195275
eMolecules	76753665

PubMed

Title	Date	PubMed
Effects on gastric secretion of WIN 4369 (monodral), a synthetic anticholinergic.	1954 Apr 15	13154614
A comparative study of three anticholinergic drugs monodral, pamine and pro-banthine.	1956 May 1	13316653
Mydriatic action of penthienate bromide; a possible substitute for atropine.	1957 Mar 23	13407076
Value of penthienate methobromide in lienteric diarrhoea and encopresis in childhood.	1958 Dec 6	13596623
Anticholinergic medication for the unstable bladder: prospective trials of imipramine/propantheline versus penthienate and oxybutynin versus penthienate.	1996	10895803
Urinary urge incontinence: randomised crossover trials of penthienate versus placebo and propantheline.	1996 Nov 4	8937366

Patents

Name

Type

Language

PENTHIENATE BROMIDE

Common Name

English

2-(2-Cyclopentyl-2-hydroxy-2-(thiophen-2-yl)acetoxy)-N,N-diethyl-N-methylethanaminium bromide

Systematic Name

English

NSC-61814

Code

English

MONODRAL BROMIDE

Brand Name

English

Penthienate bromide [WHO-DD]

Common Name

English

PENTHIENATE BROMIDE [MI]

Common Name

English

PENTHIENATE BROMIDE [MART.]

Common Name

English

Code System Code Type Description

MERCK INDEX

m873