U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C26H36O5
Molecular Weight 428.561
Optical Activity UNSPECIFIED
Defined Stereocenters 7 / 7
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DICIRENONE

SMILES

[H][C@@]12CC[C@@]3(CCC(=O)O3)[C@@]1(C)CC[C@@]4([H])[C@@]2([H])[C@@H](CC5=CC(=O)CC[C@]45C)C(=O)OC(C)C

InChI

InChIKey=WUVPAYPBMZMHJO-IMNLCBETSA-N
InChI=1S/C26H36O5/c1-15(2)30-23(29)18-14-16-13-17(27)5-9-24(16,3)19-6-10-25(4)20(22(18)19)7-11-26(25)12-8-21(28)31-26/h13,15,18-20,22H,5-12,14H2,1-4H3/t18-,19+,20+,22-,24+,25+,26-/m1/s1

HIDE SMILES / InChI
Dicirenone is an aldosterone antagonist. It is used as a hypotensive agent. Dicirenone inhibited the effects of aldosterone on urinary K(+):Na(+) ratios and the binding of [(3)H]aldosterone to renal cytoplasmic and nuclear receptors. Dicirenone blocked the action of aldosterone on Na-K ATPase. Cytoplasmic binding of [(3)H]aldosterone and dicirenone was similar in magnitude and involved the same set of sites. It had no effect on adrenal steroidogenesis.

Approval Year

Patents
Name Type Language
DICIRENONE
INN   USAN  
USAN   INN  
Official Name English
PREGN-4-ENE-7,21-DICARBOXYLIC ACID, 17-HYDROXY-3-OXO-, .GAMMA.-LACTONE, 1-METHYLETHYL ESTER, (7.ALPHA.,17.ALPHA.)-
Common Name English
DICIRENONE [USAN]
Common Name English
17-Hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic acid, γ-lactone, isopropyl ester
Common Name English
SC-26304
Code English
dicirenone [INN]
Common Name English
Code System Code Type Description
WIKIPEDIA
Dicirenone
Created by admin on Fri Dec 15 16:08:40 GMT 2023 , Edited by admin on Fri Dec 15 16:08:40 GMT 2023
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PUBCHEM
10387872
Created by admin on Fri Dec 15 16:08:40 GMT 2023 , Edited by admin on Fri Dec 15 16:08:40 GMT 2023
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FDA UNII
M8K306YKSX
Created by admin on Fri Dec 15 16:08:40 GMT 2023 , Edited by admin on Fri Dec 15 16:08:40 GMT 2023
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ChEMBL
CHEMBL2106258
Created by admin on Fri Dec 15 16:08:40 GMT 2023 , Edited by admin on Fri Dec 15 16:08:40 GMT 2023
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EPA CompTox
DTXSID101023456
Created by admin on Fri Dec 15 16:08:40 GMT 2023 , Edited by admin on Fri Dec 15 16:08:40 GMT 2023
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NCI_THESAURUS
C174699
Created by admin on Fri Dec 15 16:08:40 GMT 2023 , Edited by admin on Fri Dec 15 16:08:40 GMT 2023
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USAN
U-2
Created by admin on Fri Dec 15 16:08:40 GMT 2023 , Edited by admin on Fri Dec 15 16:08:40 GMT 2023
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INN
5449
Created by admin on Fri Dec 15 16:08:40 GMT 2023 , Edited by admin on Fri Dec 15 16:08:40 GMT 2023
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EVMPD
SUB07090MIG
Created by admin on Fri Dec 15 16:08:40 GMT 2023 , Edited by admin on Fri Dec 15 16:08:40 GMT 2023
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CAS
41020-79-5
Created by admin on Fri Dec 15 16:08:40 GMT 2023 , Edited by admin on Fri Dec 15 16:08:40 GMT 2023
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SMS_ID
100000082916
Created by admin on Fri Dec 15 16:08:40 GMT 2023 , Edited by admin on Fri Dec 15 16:08:40 GMT 2023
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