DICIRENONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H36O5
Molecular Weight	428.561
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)OC(=O)[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@]45CCC(=O)O5)[C@H]13

InChI

InChIKey=WUVPAYPBMZMHJO-IMNLCBETSA-N

InChI=1S/C26H36O5/c1-15(2)30-23(29)18-14-16-13-17(27)5-9-24(16,3)19-6-10-25(4)20(22(18)19)7-11-26(25)12-8-21(28)31-26/h13,15,18-20,22H,5-12,14H2,1-4H3/t18-,19+,20+,22-,24+,25+,26-/m1/s1

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2981534 | https://www.ncbi.nlm.nih.gov/pubmed/6274911 | https://www.ncbi.nlm.nih.gov/pubmed/4364539 | Milne, G.W., Zeman, E.J. (2017) Ashgate Handbook of Cardiovascular Agents: An International Guide to 1900 Drugs in Current Use, retrieved from: https://books.google.ru/books?id=FlM8DwAAQBAJ

Dicirenone is an aldosterone antagonist. It is used as a hypotensive agent. Dicirenone inhibited the effects of aldosterone on urinary K(+):Na(+) ratios and the binding of [(3)H]aldosterone to renal cytoplasmic and nuclear receptors. Dicirenone blocked the action of aldosterone on Na-K ATPase. Cytoplasmic binding of [(3)H]aldosterone and dicirenone was similar in magnitude and involved the same set of sites. It had no effect on adrenal steroidogenesis.

Approval Year

Patents

Name

Type

Language

DICIRENONE

Official Name

English

SC-26304

Preferred Name

English

PREGN-4-ENE-7,21-DICARBOXYLIC ACID, 17-HYDROXY-3-OXO-, .GAMMA.-LACTONE, 1-METHYLETHYL ESTER, (7.ALPHA.,17.ALPHA.)-

Common Name

English

DICIRENONE [USAN]

Common Name

English

17-Hydroxy-3-oxo-17?-pregn-4-ene-7?,21-dicarboxylic acid, ?-lactone, isopropyl ester

Common Name

English

dicirenone [INN]

Common Name

English

Code System Code Type Description

WIKIPEDIA

Dicirenone