CLOBENZTROPINE

Possibly Marketed Outside US

Details

Stereochemistry	UNKNOWN
Molecular Formula	C21H24ClNO
Molecular Weight	341.874
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=C(Cl)C=C4

InChI

InChIKey=OCAXFDULERPAJM-UHFFFAOYSA-N

InChI=1S/C21H24ClNO/c1-23-18-11-12-19(23)14-20(13-18)24-21(15-5-3-2-4-6-15)16-7-9-17(22)10-8-16/h2-10,18-21H,11-14H2,1H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8057273 | https://www.ncbi.nlm.nih.gov/pubmed/7562926

3-CPMT (3α-[(4-Chlorophenyl)phenylmethoxy] tropane) is a dopamine uptake inhibitor. Behavioral studies suggested that it did not display a cocaine-like behavioral profile, despite their ability to inhibit dopamine uptake.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine transporter 180 Target ID: CHEMBL338 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8057273	Inhibitor 8297		30.0 nM [Ki]
Dopamine transporter 180 Target ID: CHEMBL338 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8057273	Inhibitor 8297		30.0 nM [Ki]

PubMed

Title	Date	PubMed
Effects of 4'-chloro-3 alpha-(diphenylmethoxy)-tropane on mesostriatal, mesocortical, and mesolimbic dopamine transmission: comparison with effects of cocaine.	2005 May	15681658
Transport, metabolism, and in vivo population pharmacokinetics of the chloro benztropine analogs, a class of compounds extensively evaluated in animal models of drug abuse.	2007 Jan	17003230

Patents

Name

Type

Language

CLOBENZTROPINE

Official Name

English

3-((P-CHLORO-.ALPHA.-PHENYLBENZYL)OXY)TROPANE

Common Name

English

clobenztropine [INN]

Common Name

English

CLOBENZTROPINE [MI]

Common Name

English

Code System Code Type Description

SMS_ID

100000084301