Retusin is an O-methylated isoflavone, a type of flavonoid. It can be found in Fabaceae species like Dipteryx odorata, in Dalbergia retusa and in Millettia nitida. Retusin exhibited potent free-radical-scavenging capacity as well as efficient inhibition of cellular melanogenesis, suggesting that it is a valuable hit compound with potential for advanced cosmeceutical development. Retusin showed efficient inhibition both of cellular melanin formation and anti-tyrosinase activity in B16F10 melanocytes. Retusin exhibited an anti-emetic effect in chick model.