U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Description
Curator's Comment: description was created based on several sources, including: http://www.drugbank.ca/drugs/DB01135

Doxacurium chloride (formerly recognized as BW938U80 or BW A938U) is a neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in anesthesia for endotracheal intubation or to facilitate mechanical ventilation. Unlike a number of other related skeletal muscle relaxants, it is rarely used adjunctively to facilitate endotracheal intubation. Doxacurium chloride is a mixture of three trans, trans stereoisomers, a dl pair [(1R,1'R ,2S,2'S ) and (1S,1'S ,2R,2'R )] and a meso form (1R,1'S,2S,2'R). NUROMAX binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a block of neuromuscular transmission. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine.

Originator

Curator's Comment: synthesized by Mary M. Jackson and James C. Wisowaty, PhD (both chemists within the Chemical Development Laboratories at Burroughs Wellcome Co., Research Triangle Park, NC) in collaboration with John J. Savarese MD (who at the time was an anesthesiologist in the Dept. of Anesthesia, Harvard Medical School at the Massachusetts General Hospital, Boston, MA).

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
NUROMAX

Approved Use

NUROMAX is a long-acting neuromuscular blocking agent, indicated to provide skeletal muscle relaxation as an adjunct to general anesthesia, for endotracheal intubation or to facilitate mechanical ventilation.

Launch Date

1991
Preventing
NUROMAX

Approved Use

NUROMAX is a long-acting neuromuscular blocking agent, indicated to provide skeletal muscle relaxation as an adjunct to general anesthesia, for endotracheal intubation or to facilitate mechanical ventilation.

Launch Date

1991
PubMed

PubMed

TitleDatePubMed
Optimal dosing regimen of biapenem in Chinese patients with lower respiratory tract infections based on population pharmacokinetic/pharmacodynamic modelling and Monte Carlo simulation.
2016 Mar
Patents

Sample Use Guides

adults: An initial NUROMAX dose of 0.08 mg/kg (3 × ED95) should be reserved for instances in which a need for very prolonged neuromuscular block is anticipated. Children: When administered during halothane anesthesia, an initial dose of 0.03 mg/kg (ED95) produces maximum neuromuscular block in about 7 minutes (range: 5 to 11) and clinically effective block for an average of 30 minutes (range: 12 to 54).
Route of Administration: Intravenous
In Vitro Use Guide
Unknown
Name Type Language
DOXACURIUM CHLORIDE
INN   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
USAN   INN  
Official Name English
DOXACURIUM CHLORIDE [ORANGE BOOK]
Common Name English
Doxacurium chloride [WHO-DD]
Common Name English
2,2'-((1,4-DIOXOBUTANE-1,4-DIYL)BIS(OXYPROPANE-3,1-DIYL))BIS(6,7,8-TRIMETHOXY-2-METHYL-1-(3,4,5-TRIMETHOXYBENZYL)-1,2,3,4-TETRAHYDROISOQUINOLINIUM) DICHLORIDE
Common Name English
BW-A938U
Code English
ISOQUINOLINIUM, 2,2'-((1,4-DIOXO-1,4-BUTANEDIYL)BIS(OXY-3,1-PROPANEDIYL))BIS(1,2,3,4-TETRAHYDRO-6,7,8-TRIMETHOXY-2-METHYL-1-((3,4,5-TRIMETHOXYPHENYL)METHYL)-, DICHLORIDE
Common Name English
doxacurium chloride [INN]
Common Name English
BW A938U DICHLORIDE
Code English
DOXACURIUM CHLORIDE [MART.]
Common Name English
BW-938U DICHLORIDE
Code English
DOXACURIUM CHLORIDE [VANDF]
Common Name English
NUROMAX
Brand Name English
BW-A938U DICHLORIDE
Code English
DOXACURIUM CHLORIDE [USAN]
Common Name English
Classification Tree Code System Code
WHO-VATC QM03AC07
Created by admin on Sat Dec 16 17:37:59 GMT 2023 , Edited by admin on Sat Dec 16 17:37:59 GMT 2023
WHO-ATC M03AC07
Created by admin on Sat Dec 16 17:37:59 GMT 2023 , Edited by admin on Sat Dec 16 17:37:59 GMT 2023
NCI_THESAURUS C29696
Created by admin on Sat Dec 16 17:37:59 GMT 2023 , Edited by admin on Sat Dec 16 17:37:59 GMT 2023
Code System Code Type Description
FDA UNII
M78TVM3G5Z
Created by admin on Sat Dec 16 17:37:59 GMT 2023 , Edited by admin on Sat Dec 16 17:37:59 GMT 2023
PRIMARY
NCI_THESAURUS
C65472
Created by admin on Sat Dec 16 17:37:59 GMT 2023 , Edited by admin on Sat Dec 16 17:37:59 GMT 2023
PRIMARY
SMS_ID
100000080770
Created by admin on Sat Dec 16 17:37:59 GMT 2023 , Edited by admin on Sat Dec 16 17:37:59 GMT 2023
PRIMARY
RXCUI
49275
Created by admin on Sat Dec 16 17:37:59 GMT 2023 , Edited by admin on Sat Dec 16 17:37:59 GMT 2023
PRIMARY RxNorm
MERCK INDEX
m4750
Created by admin on Sat Dec 16 17:37:59 GMT 2023 , Edited by admin on Sat Dec 16 17:37:59 GMT 2023
PRIMARY Merck Index
INN
6205
Created by admin on Sat Dec 16 17:37:59 GMT 2023 , Edited by admin on Sat Dec 16 17:37:59 GMT 2023
PRIMARY
EVMPD
SUB06380MIG
Created by admin on Sat Dec 16 17:37:59 GMT 2023 , Edited by admin on Sat Dec 16 17:37:59 GMT 2023
PRIMARY
WIKIPEDIA
DOXACURIUM CHLORIDE
Created by admin on Sat Dec 16 17:37:59 GMT 2023 , Edited by admin on Sat Dec 16 17:37:59 GMT 2023
PRIMARY
CAS
83348-52-1
Created by admin on Sat Dec 16 17:37:59 GMT 2023 , Edited by admin on Sat Dec 16 17:37:59 GMT 2023
PRIMARY
DRUG BANK
DBSALT002766
Created by admin on Sat Dec 16 17:37:59 GMT 2023 , Edited by admin on Sat Dec 16 17:37:59 GMT 2023
PRIMARY
USAN
Z-9
Created by admin on Sat Dec 16 17:37:59 GMT 2023 , Edited by admin on Sat Dec 16 17:37:59 GMT 2023
PRIMARY
ChEMBL
CHEMBL1237123
Created by admin on Sat Dec 16 17:37:59 GMT 2023 , Edited by admin on Sat Dec 16 17:37:59 GMT 2023
PRIMARY
CHEBI
4707
Created by admin on Sat Dec 16 17:37:59 GMT 2023 , Edited by admin on Sat Dec 16 17:37:59 GMT 2023
PRIMARY
All of the following components must be present:
Definition References