PIPAZETHATE

First approved in 1962

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H25N3O3S
Molecular Weight	399.507
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C(OCCOCCN1CCCCC1)N2C3=CC=CC=C3SC4=CC=CN=C24

InChI

InChIKey=DTVJXCOMJLLMAK-UHFFFAOYSA-N

InChI=1S/C21H25N3O3S/c25-21(27-16-15-26-14-13-23-11-4-1-5-12-23)24-17-7-2-3-8-18(17)28-19-9-6-10-22-20(19)24/h2-3,6-10H,1,4-5,11-16H2

HIDE SMILES / InChI

Description
Sources: http://www.hmdb.ca/metabolites/HMDB0015686 | https://www.ncbi.nlm.nih.gov/pubmed/5328471

PIPAZETHATE is a non-narcotic oral antitussive agent. It acts centrally on the medullary cough center and is used for the treatment of cough.

CNS Activity

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cough 106 Sources: https://www.drugbank.ca/drugs/DB08796	Primary		Approved 8583	Theratuss Approved Use Pipazethate is a centrally acting antitussive drug that also has bronchodilatory and local anesthetic activities. Launch Date 1962

Doses

Dose	Population	Adverse events
40 mg/mL single, oral Overdose Dose: 40 mg/mL Route: oral Route: single Dose: 40 mg/mL Sources: https://pubmed.ncbi.nlm.nih.gov/7180211	healthy, 32 months Health Status: healthy Age Group: 32 months Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/7180211	Other AEs: Tonic-clonic seizures, Coma... Other AEs: Tonic-clonic seizures (grade 5, 1 patient) Coma (grade 5, 1 patient) Respiratory insufficiency (grade 5, 1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/7180211

AEs

AE	Significance	Dose	Population
Coma	grade 5, 1 patient	40 mg/mL single, oral Overdose Dose: 40 mg/mL Route: oral Route: single Dose: 40 mg/mL Sources: https://pubmed.ncbi.nlm.nih.gov/7180211	healthy, 32 months Health Status: healthy Age Group: 32 months Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/7180211
Respiratory insufficiency	grade 5, 1 patient	40 mg/mL single, oral Overdose Dose: 40 mg/mL Route: oral Route: single Dose: 40 mg/mL Sources: https://pubmed.ncbi.nlm.nih.gov/7180211	healthy, 32 months Health Status: healthy Age Group: 32 months Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/7180211
Tonic-clonic seizures	grade 5, 1 patient	40 mg/mL single, oral Overdose Dose: 40 mg/mL Route: oral Route: single Dose: 40 mg/mL Sources: https://pubmed.ncbi.nlm.nih.gov/7180211	healthy, 32 months Health Status: healthy Age Group: 32 months Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/7180211

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY540919	https://www.001chemical.com/chem/2167-85-3
ABI Chem	AC1L2KDQ
ABI Chem	AC1Q68DF
Alfa Chemistry	ACM14056678
BOC Sciences	1518261
BOC Sciences	2167-85-3
ChemMol	99053672	http://www.chemmol.com/chemmol/99053672.html
Compound Cloud	22425
eMolecules	110068230
eMolecules	300635622
eMolecules	43551997
eNovation Chemicals	D674615	https://www.enovationchem.com/ProductDetails.asp?ProductID=D674615
Hangzhou Yuhao Chemical Technology	RT8539
Molcore	MC540919	https://www.molcore.com/product/2167-85-3
MolPort	MolPort-006-113-900	https://www.molport.com/shop/molecule-link/MolPort-006-113-900
MuseChem	I008771
MuseChem	R055706
NCI Plated 2007	106961
NovoSeek	22425
Smolecule	S539724	http://www.smolecule.com/products/s539724
THE BioTek	bt-278393	https://www.thebiotek.com/product/inhibitors/bt-278393
Toronto Research Chemicals	F591410
Toronto Research Chemicals	P475700
ZINC	ZINC000001698105	http://zinc15.docking.org/substances/ZINC000001698105

PubMed

Title	Date	PubMed
Spectrophotometric determination of pipazethate HCl, dextromethorphan HBr and drotaverine HCl in their pharmaceutical preparations.	2007 Jul	17092767

Name

Type

Language

PIPAZETHATE

Official Name

English

PIPAZETATE

Preferred Name

English

SK&F 70230-A

Code

English

Pipazetate [WHO-DD]

Common Name

English

10H-PYRIDO(3,2-B)(1,4)BENZOTHIAZINE-10-CARBOXYLIC ACID, 2-(2-(1-PIPERIDINYL)ETHOXY)ETHYL ESTER

Common Name

English

2-(2-Piperidinoethoxy)ethyl 10H-pyrido[3,2-b][1,4]benzothiazine-10-carboxylate

Systematic Name

English

PIPAZETATE [MART.]

Common Name

English

PIPAZETHATE [USAN]

Common Name

English

pipazetate [INN]

Common Name

English

PIPAZETHATE [MI]

Common Name

English

D-254

Code

English

SQ 15,874

Code

English

SQ-15874

Code

English

SK&F-70230-A

Code

English

Classification Tree Code System Code

WHO-ATC

R05DB11