PIPAZETHATE

First approved in 1962

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H25N3O3S
Molecular Weight	399.507
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C(OCCOCCN1CCCCC1)N2C3=C(SC4=C2N=CC=C4)C=CC=C3

InChI

InChIKey=DTVJXCOMJLLMAK-UHFFFAOYSA-N

InChI=1S/C21H25N3O3S/c25-21(27-16-15-26-14-13-23-11-4-1-5-12-23)24-17-7-2-3-8-18(17)28-19-9-6-10-22-20(19)24/h2-3,6-10H,1,4-5,11-16H2

HIDE SMILES / InChI

Description
Sources: http://www.hmdb.ca/metabolites/HMDB0015686 | https://www.ncbi.nlm.nih.gov/pubmed/5328471

PIPAZETHATE is a non-narcotic oral antitussive agent. It acts centrally on the medullary cough center and is used for the treatment of cough.

CNS Activity

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cough 106 Sources: https://www.drugbank.ca/drugs/DB08796	Primary		Approved 8429	Theratuss Approved Use Pipazethate is a centrally acting antitussive drug that also has bronchodilatory and local anesthetic activities. Launch Date -2.52460794E11

Doses

Dose	Population	Adverse events
40 mg/mL single, oral Overdose Dose: 40 mg/mL Route: oral Route: single Dose: 40 mg/mL Sources: https://pubmed.ncbi.nlm.nih.gov/7180211	healthy, 32 months n = 1 Health Status: healthy Age Group: 32 months Sex: F Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/7180211	Other AEs: Tonic-clonic seizures, Coma... Other AEs: Tonic-clonic seizures (grade 5, 1 patient) Coma (grade 5, 1 patient) Respiratory insufficiency (grade 5, 1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/7180211

AEs

AE	Significance	Dose	Population
Coma	grade 5, 1 patient	40 mg/mL single, oral Overdose Dose: 40 mg/mL Route: oral Route: single Dose: 40 mg/mL Sources: https://pubmed.ncbi.nlm.nih.gov/7180211	healthy, 32 months n = 1 Health Status: healthy Age Group: 32 months Sex: F Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/7180211
Respiratory insufficiency	grade 5, 1 patient	40 mg/mL single, oral Overdose Dose: 40 mg/mL Route: oral Route: single Dose: 40 mg/mL Sources: https://pubmed.ncbi.nlm.nih.gov/7180211	healthy, 32 months n = 1 Health Status: healthy Age Group: 32 months Sex: F Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/7180211
Tonic-clonic seizures	grade 5, 1 patient	40 mg/mL single, oral Overdose Dose: 40 mg/mL Route: oral Route: single Dose: 40 mg/mL Sources: https://pubmed.ncbi.nlm.nih.gov/7180211	healthy, 32 months n = 1 Health Status: healthy Age Group: 32 months Sex: F Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/7180211

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY540919	https://www.001chemical.com/chem/2167-85-3
ABI Chem	AC1L2KDQ
ABI Chem	AC1Q68DF
Alfa Chemistry	ACM14056678
BOC Sciences	1518261
BOC Sciences	2167-85-3
ChemMol	99053672	http://www.chemmol.com/chemmol/99053672.html
Compound Cloud	22425
Hangzhou Yuhao Chemical Technology	RT8539
MolPort	MolPort-006-113-900	https://www.molport.com/shop/molecule-link/MolPort-006-113-900
Molcore	MC540919	https://www.molcore.com/product/2167-85-3
MuseChem	I008771
MuseChem	R055706
NCI Plated 2007	106961
NovoSeek	22425
Smolecule	S539724	http://www.smolecule.com/products/s539724
THE BioTek	bt-278393	https://www.thebiotek.com/product/inhibitors/bt-278393
Toronto Research Chemicals	F591410
Toronto Research Chemicals	P475700
ZINC	ZINC000001698105	http://zinc15.docking.org/substances/ZINC000001698105
eMolecules	110068230
eMolecules	300635622
eMolecules	43551997
eNovation Chemicals	D674615	https://www.enovationchem.com/ProductDetails.asp?ProductID=D674615

PubMed

Title	Date	PubMed
Spectrophotometric determination of molybdenum(VI) using isothipendyl hydrochloride and pipazethate hydrochloride in alloy steels and soil samples.	2001 Sep	11708072
Spectrophotometric determination of pipazethate HCl, dextromethorphan HBr and drotaverine HCl in their pharmaceutical preparations.	2007 Jul	17092767
Flow injection potentiometric assay of hexoprenaline in its pure state, pharmaceutical preparations, and biological samples.	2008	18483573
Adverse drug effects in hospitalized elderly: data from the healthcare cost and utilization project.	2010	22291486

Name

Type

Language

PIPAZETHATE

Official Name

English

SK&F 70230-A

Code

English

Pipazetate [WHO-DD]

Common Name

English

10H-PYRIDO(3,2-B)(1,4)BENZOTHIAZINE-10-CARBOXYLIC ACID, 2-(2-(1-PIPERIDINYL)ETHOXY)ETHYL ESTER

Common Name

English

2-(2-Piperidinoethoxy)ethyl 10H-pyrido[3,2-b][1,4]benzothiazine-10-carboxylate

Systematic Name

English

PIPAZETATE [MART.]

Common Name

English

PIPAZETHATE [USAN]

Common Name

English

pipazetate [INN]

Common Name

English

PIPAZETHATE [MI]

Common Name

English

D-254

Code

English

SQ 15,874

Code

English

SQ-15874

Code

English

PIPAZETATE

Official Name

English

SK&F-70230-A

Code

English

Classification Tree Code System Code

WHO-ATC

R05DB11

Created by admin on Fri Dec 15 15:01:44 UTC 2023 , Edited by admin on Fri Dec 15 15:01:44 UTC 2023

WHO-VATC

QR05DB11

Created by admin on Fri Dec 15 15:01:44 UTC 2023 , Edited by admin on Fri Dec 15 15:01:44 UTC 2023

NCI_THESAURUS

C66917

Created by admin on Fri Dec 15 15:01:44 UTC 2023 , Edited by admin on Fri Dec 15 15:01:44 UTC 2023

Code System Code Type Description

SMS_ID

100000081981

Created by admin on Fri Dec 15 15:01:44 UTC 2023 , Edited by admin on Fri Dec 15 15:01:44 UTC 2023

PRIMARY

WIKIPEDIA

PIPAZETATE

Created by admin on Fri Dec 15 15:01:45 UTC 2023 , Edited by admin on Fri Dec 15 15:01:45 UTC 2023

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MESH

C016064

Created by admin on Fri Dec 15 15:01:44 UTC 2023 , Edited by admin on Fri Dec 15 15:01:44 UTC 2023

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CAS

2167-85-3

Created by admin on Fri Dec 15 15:01:44 UTC 2023 , Edited by admin on Fri Dec 15 15:01:44 UTC 2023

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FDA UNII

M5EK1T5V2L

Created by admin on Fri Dec 15 15:01:44 UTC 2023 , Edited by admin on Fri Dec 15 15:01:44 UTC 2023

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DRUG BANK

DB08796

Created by admin on Fri Dec 15 15:01:44 UTC 2023 , Edited by admin on Fri Dec 15 15:01:44 UTC 2023

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PUBCHEM

22425

Created by admin on Fri Dec 15 15:01:44 UTC 2023 , Edited by admin on Fri Dec 15 15:01:44 UTC 2023

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MERCK INDEX

m8839

Created by admin on Fri Dec 15 15:01:44 UTC 2023 , Edited by admin on Fri Dec 15 15:01:44 UTC 2023

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Merck Index

NCI_THESAURUS

C82252

Created by admin on Fri Dec 15 15:01:44 UTC 2023 , Edited by admin on Fri Dec 15 15:01:44 UTC 2023

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ECHA (EC/EINECS)

218-508-8

Created by admin on Fri Dec 15 15:01:44 UTC 2023 , Edited by admin on Fri Dec 15 15:01:44 UTC 2023

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ChEMBL

CHEMBL2104900

Created by admin on Fri Dec 15 15:01:44 UTC 2023 , Edited by admin on Fri Dec 15 15:01:44 UTC 2023

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INN

1124

Created by admin on Fri Dec 15 15:01:44 UTC 2023 , Edited by admin on Fri Dec 15 15:01:44 UTC 2023

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EVMPD

SUB09861MIG

Created by admin on Fri Dec 15 15:01:44 UTC 2023 , Edited by admin on Fri Dec 15 15:01:44 UTC 2023

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DRUG CENTRAL

2182

Created by admin on Fri Dec 15 15:01:44 UTC 2023 , Edited by admin on Fri Dec 15 15:01:44 UTC 2023

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EPA CompTox

DTXSID40176056

Created by admin on Fri Dec 15 15:01:44 UTC 2023 , Edited by admin on Fri Dec 15 15:01:44 UTC 2023

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RXCUI

33740

Created by admin on Fri Dec 15 15:01:44 UTC 2023 , Edited by admin on Fri Dec 15 15:01:44 UTC 2023

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RxNorm

ACTIVE MOIETY


					M5EK1T5V2L

PIPAZETHATE

Details

SMILES

InChI

DescriptionSources: http://www.hmdb.ca/metabolites/HMDB0015686 | https://www.ncbi.nlm.nih.gov/pubmed/5328471

CNS Activity

Approval Year

Conditions

Approved Use

Launch Date

Doses

AEs

Sourcing

PubMed

Description
Sources: http://www.hmdb.ca/metabolites/HMDB0015686 | https://www.ncbi.nlm.nih.gov/pubmed/5328471