MANGANESE GLYCEROPHOSPHATE

First marketed in 1921

Description
Sources: https://www.alfa.com/en/catalog/032808/https://www.ncbi.nlm.nih.gov/pubmed/6658791https://www.ncbi.nlm.nih.gov/pubmed/3725729 | https://www.ncbi.nlm.nih.gov/pubmed/3989083 | https://www.ncbi.nlm.nih.gov/pubmed/25464291 | https://www.ncbi.nlm.nih.gov/pubmed/20934746https://google.com/patents/CN104529454A?http://pubs.acs.org/doi/pdfplus/10.1021/jo970656jhttps://www.drugs.com/pro/manganese-sulfate-injection.htmlhttp://www.druginfosys.com/drug.aspx?drugcode=2295&type=1https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=184 | https://www.ncbi.nlm.nih.gov/pubmed/24861367
Curator's Comment: description was created based on several sources, including https://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/SCOGS/ucm260883.htm

Manganese citrate is generally recognized as safe direct food additive. Manganese citrate complex has being used in the determination of liver enzyme activities in the aging process and following treatment with aminoethylisothiuronium bromide hydrobromide (AET).

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Arginase-1 25 Target ID: CHEMBL1075097 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19032027	Activator 1430
Arginase-2, mitochondrial 24 Target ID: CHEMBL1795148 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25974698	Activator 1430
Glutamine synthetase 29 Target ID: CHEMBL4612 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25974698	Activator 1430

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2578
Unknown 2578
Unknown 2578
Cancer 592 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20934746	Primary	Basic research	Unknown Approved Use Unknown
Manganese deficiency 27 Sources: http://www.webmd.com/vitamins-supplements/ingredientmono-182-manganese.aspx?activeingredientid=182&	Primary	Approved 8429	Unknown Approved Use Manganese is used for prevention and treatment of manganese deficiency, a condition in which the body doesn’t have enough manganese.
Osteoporosis 97 Sources: http://www.webmd.com/vitamins-supplements/ingredientmono-182-manganese.aspx?activeingredientid=182&	Primary	Approved 8429	Unknown Approved Use Manganese is used for weak bones (osteoporosis).
Premenstrual syndrome 37 Sources: http://www.webmd.com/vitamins-supplements/ingredientmono-182-manganese.aspx?activeingredientid=182&	Palliative	Approved 8429	Unknown Approved Use Early research suggests that taking manganese along with calcium helps improve symptoms of PMS, including pain, crying, loneliness, anxiety, restlessness, irritability, mood swings, depression, and tension.
Manganese deficiency 27 Sources: https://www.drugs.com/pro/manganese-sulfate-injection.html	Curative	Approved 8429	MANGANESE SULFATE Approved Use Manganese Sulfate Injection, USP is indicated for use as a supplement to intravenous solutions given for Total Parenteral Nutrition (TPN). Administration helps to maintain plasma levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
Unknown 2578
Unknown 2578
Gastrointestinal disorders 95 Sources: https://www.drugs.com/cdi/magnesium-sulfate.html	Primary	Approved 8429	MANGANESE SULFATE Approved Use Unknown

PubMed

Title	Date	PubMed
Cytochrome oxidase determination using a manganese citrate complex.	1970	4322423
Metabolism of l-Tyrosine to 4-Hydroxybenzaldehyde and 3-Bromo-4-Hydroxybenzaldehyde by Chloroplast-containing Fractions of Odonthalia floccosa (Esp.) Falk.	1979 Dec	16661087
Effect of fluoride on copper, manganese and zinc in bone and kidney.	1981 Mar	7284642
Effect of quantity and route of administration of manganese monoxide on feed intake and serum manganese in ruminants.	1985 Feb	3989083
Transformation of BALB/c-3T3 cells: IV. Rank-ordered potency of 24 chemical responses detected in a sensitive new assay procedure.	1993 Jul	8243401
Dietary calcium and manganese effects on menstrual cycle symptoms.	1993 May	8498421
Manganese citrate improves base-calling accuracy in DNA sequencing reactions using rhodamine-based fluorescent dye-terminators.	1999 Mar 1	9973633
Manganese: brain transport and emerging research needs.	2000 Jun	10852840
Manganese citrate chemistry: syntheses, spectroscopic studies, and structural characterizations of novel mononuclear, water-soluble manganese citrate complexes.	2000 Sep 4	11198859
Equilibrium and kinetics studies of reactions of manganese acetate, cobalt acetate, and bromide salts in acetic acid solutions.	2001 Jun 18	11399197
Differential ability of transition metals to induce pulmonary inflammation.	2001 Nov 15	11708899
Tetraaqua(1,10-phenanthroline-kappa(2)N,N')manganese(II) sulfate dihydrate.	2002 Jul	12094041
Is the axial zero-field splitting parameter of tetragonally elongated high-spin manganese(III) complexes always negative?	2002 Jul 31	12137507
Glutamate/aspartate transporter (GLAST), taurine transporter and metallothionein mRNA levels are differentially altered in astrocytes exposed to manganese chloride, manganese phosphate or manganese sulfate.	2002 Sep	12387356
Manganese distribution across the blood-brain barrier. I. Evidence for carrier-mediated influx of managanese citrate as well as manganese and manganese transferrin.	2003 Jan	12564377
Bi- and poly-metallic cyanide-bridged complexes of the redox-active cyanomanganese nitrosyl unit [Mn(CN)(PR3)(NO)(eta-C5H4Me)].	2004 Feb 21	15252534
Manganese potentiates in vitro production of proinflammatory cytokines and nitric oxide by microglia through a nuclear factor kappa B-dependent mechanism.	2005 Mar	15601679
Persistent alterations in biomarkers of oxidative stress resulting from combined in utero and neonatal manganese inhalation.	2005 May	15894815
Decreased expression of inflammation-related genes following inhalation exposure to manganese.	2006 May	16476481
CsR(R(6)CoI(12))2 (R = Gd, Er) and (CeI)0.26(Ce(6)MnI(9))2: two new structure types featuring R(6)Z clusters.	2006 Nov 27	17112265
Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese.	2006 Summer	16943606
Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity.	2007 Jun	17347134
Effects of chronic manganese exposure on glutamatergic and GABAergic neurotransmitter markers in the nonhuman primate brain.	2009 Sep	19520674
Expression profile analysis of antioxidative stress and developmental pathway genes in the manganese-exposed intertidal copepod Tigriopus japonicus with 6K oligochip.	2013 Aug	23714145
Safety Assessment of Citric Acid, Inorganic Citrate Salts, and Alkyl Citrate Esters as Used in Cosmetics.	2014 May	24861367
Controlled Synthesis of Hollow Manganese Oxide Nanocrystals.	2016 Feb	27433689
Chronic exposure to manganese sulfate leads to adverse dose-dependent effects on the neurobehavioral ability of rats.	2016 Nov	26097037
Yolk-Shell MnO@ZnMn(2) O(4) /N-C Nanorods Derived from α-MnO(2) /ZIF-8 as Anode Materials for Lithium Ion Batteries.	2016 Oct	27562457
Top-Down Strategy to Synthesize Mesoporous Dual Carbon Armored MnO Nanoparticles for Lithium-Ion Battery Anodes.	2017 Apr 12	28333439
Intramolecular Aminoalkoxylation of Unfunctionalized Olefins via Intramolecular Iodoamination and Aziridinium Ion Ring-Opening Sequence.	2017 Apr 7	28333470

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Name

Type

Language

MANGANESE GLYCEROPHOSPHATE

Official Name

English

MANGANESE GLYCEROPHOSPHATE [INCI]

Common Name

English

Manganese glycerophosphate [WHO-DD]

Common Name

English

MANGANESE (AS GLYCEROPHOSPHATE) [VANDF]

Common Name

English

MANGANESE GLYCEROPHOSPHATE [FCC]

Common Name

English

GLYCEROL PHOSPHATE MANGANESE SALT

Common Name

English

Code System Code Type Description

FDA UNII

LR135I04CJ