1,3-DI-O-TOLYLGUANIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H17N3
Molecular Weight	239.3156
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(NC(=N)NC2=C(C)C=CC=C2)C=CC=C1

InChI

InChIKey=OPNUROKCUBTKLF-UHFFFAOYSA-N

InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)

HIDE SMILES / InChI

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Sigma opioid receptor 63 Target ID: CHEMBL287 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8027978	Agonist 2678		107.0 nM [Ki]

PubMed

Title	Date	PubMed
Effect of sigma ligands on the cocaine-induced convulsions in mice.	1999 Nov-Dec	10817525
Biperiden hydrochlorate ameliorates dystonia of rats produced by microinjection of sigma ligands into the red nucleus.	2000 Nov	11164078
Pharmacology of [3H]R(+)-7-OH-DPAT binding in the rat caudate-putamen.	2001 Jan	10913686
N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice.	2001 Jan 12	11164383
Pharmacological actions of AH-9700 on micturition reflex in anesthetized rats.	2001 Jan 26	11165228
Evidence for sigma-1-like receptors in isolated rat liver mitochondrial membranes.	2002 Apr	11934800
Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons.	2002 Jun	12037190
Antiproliferative and cytotoxic effects of some sigma2 agonists and sigma1 antagonists in tumour cell lines.	2004 Aug	15322732
Dermal absorption of aromatic amines in workers with different skin lesions: a report on 4 cases.	2006 Jul 19	16854230
sigma(2)-receptor ligand-mediated inhibition of inwardly rectifying K(+) channels in the heart.	2007 Jul	17460149
sigma-1 receptor modulation of acid-sensing ion channel a (ASIC1a) and ASIC1a-induced Ca2+ influx in rat cortical neurons.	2008 Nov	18723775
Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine.	2010 Feb	19892920
The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine.	2010 Nov 22	21092190
The sigma agonist 1,3-di-o-tolyl-guanidine directly blocks SK channels in dopaminergic neurons and in cell lines.	2010 Sep 1	20546722

Patents

Name

Type

Language

1,3-DI-O-TOLYLGUANIDINE

Common Name

English

VULCAFOR DOTG

Common Name

English

DOTG

Common Name

English

GUANIDINE, 1,3-DI-O-TOLYL-

Common Name

English

GUANIDINE, N,N'-BIS(2-METHYLPHENYL)-

Systematic Name

English

NOCCELER DT

Common Name

English

EVEITE DOTG

Common Name

English

SOXINOL DT

Common Name

English

SANCELER DT

Common Name

English

N,N'-DI-O-TOLYLGUANIDINE

Common Name

English

AKROCHEM DOTG

Common Name

English

1,3-DI-2-TOLYLGUANIDINE

Systematic Name

English

DI-O-TOLYLGUANIDINE

Common Name

English

VULKACIT DOTG

Common Name

English

1,3-BIS(O-TOLYL)GUANIDINE

Common Name

English

N,N'-BIS(2-METHYLPHENYL)GUANIDINE [HSDB]

Common Name

English

NSC-132023

Code

English

N,N'-BIS(2-METHYLPHENYL)GUANIDINE

Systematic Name

English

NSC-473

Code

English

RHENOGRAN DOTG 70

Common Name

English

Code System Code Type Description

CAS

97-39-2